Effects of nimodipine and isradipine on endothelin-1-induced contraction of pregnant rat myometrium

Kaya, Tijen; Çetin, Ali; Çetin, Meral; Sarıoğlu, Yusuf

doi:10.1016/s0014-2999(98)00140-x

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…By inhibiting contraction coupling, dihydropyridines decrease the frequency and intensity of myometrial activity (20). Our results agree with previous studies (19, 21, 22) where isradipine has been shown to inhibit myometrial activity of rat uterus by decreasing the frequency and amplitude of contractions. The results obtained from the pregnant human uterus were quantitatively quite similar with those from the rat uterus.…”

Section: Discussionsupporting

confidence: 93%

Effect of magnesium sulfate, isradipine, and ritodrine on contractions of myometrium: pregnant human and rat

Kantas¹,

Çetin²,

Kaya

et al. 2002

Acta Obstet Gynecol Scand

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Section: Discussionsupporting

confidence: 93%

Effect of magnesium sulfate, isradipine, and ritodrine on contractions of myometrium: pregnant human and rat

Kantas¹,

Çetin²,

Kaya

et al. 2002

Acta Obstet Gynecol Scand

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“…19,24 There are some studies reported that calcium channel blockers have a beneficial effect in preventing preterm labor. 18,19,25 The calcium channel blockers prevent the extracellular calcium entry through voltage-dependent calcium channels into myometrial smooth muscle cells. In addition, the calcium release from the intracellular sarcolemma is inhibited by the calcium channel blockers.…”

Section: Discussionmentioning

confidence: 99%

“…19,26 The previous studies have generally focused on dihydropyridines. 18,25 diltiazem is another voltage-dependent calcium channel blocker and may result in myometrial relaxation via the inhibition of the influx of extracellular calcium ions. In previous clinical reports, it was shown no significant differences in either efficacy or side effects between diltiazem and dihydropyridines as a tocolytic agent.…”

Section: Discussionmentioning

confidence: 99%

Kronik Sigara ve Alkol Maruziyetinin Gebe Rat Miyometriyum Oksitosin- ve Diltiazem- Aracılı Fonksiyonel Yanıtları Üzerine Etkileri

Göçmez

Korun

Şahin

et al. 2021

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi

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Objective: Smoking and alcohol consumption during pregnancy lead to undesired effects on labor. Although the underlying mechanisms are still poorly understood, impaired functional responses of myometrium may be one of the reasons for these complications. In this study, we investigated the effects of chronic smoking and alcohol consumption on the functional responses of isolated term-pregnant rat myometrium strips. Methods: 21 Wistar albino rats were divided into three groups: Control; Smoking group, rats exposed to smoke for 12 weeks; Alcohol group, rats were administered ethanol for 12 weeks (n=7 in each group). The reactivities of myometrial smooth muscle strips obtained from term labor rats were mounted in organ chambers for the recording of isometric tension. The effects of cumulative concentrations of carbachol (10 -8 -10 -4 M), oxytocin (10 -9 -10 -3 M), and diltiazem (10 -8 -10 -4 M) on myometrial spontaneous contractions were measured. Results: The amplitude and frequency of carbachol contractile responses decreased in the alcohol group, whereas it significantly increased in the smoking group. The frequency of oxytocin-induced myometrial contractions was significantly increased by smoking, while the amplitude of contractions was not changed. Oxytocin responses as amplitude and frequency of contractions decreased in the alcohol group. There were no significant differences between relaxant responses to diltiazem in both group compared to the controls. Conclusion:These findings show that smoking may lead to premature labor and alcohol consumption may prolong gestation length by changing contractile and relaxant responses in myometrial smooth muscle. Diltiazem may have a beneficial effect on tocolysis in both conditions during pregnancy.

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Effects of 5-nitro-2-(3-phenylpropylamino) benzoic acid, anthracene-9-carboxylate, and zaprinast on endothelin-1-induced contractions of pregnant rat myometrium

Kaya

Güvenal

Karadaş

et al. 2002

European Journal of Obstetrics & Gynecology and Reproductiv

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Effects of nimodipine and isradipine on endothelin-1-induced contraction of pregnant rat myometrium

Cited by 5 publications

References 14 publications

Effect of magnesium sulfate, isradipine, and ritodrine on contractions of myometrium: pregnant human and rat

Effect of magnesium sulfate, isradipine, and ritodrine on contractions of myometrium: pregnant human and rat

Kronik Sigara ve Alkol Maruziyetinin Gebe Rat Miyometriyum Oksitosin- ve Diltiazem- Aracılı Fonksiyonel Yanıtları Üzerine Etkileri

Effects of 5-nitro-2-(3-phenylpropylamino) benzoic acid, anthracene-9-carboxylate, and zaprinast on endothelin-1-induced contractions of pregnant rat myometrium

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