EFFECTS OF Nigella sativa, Zingiber officinale, Cinnamomum zeylanicum ON SERUM LIPID PROFILE, GLUCOSE, WEIGHT, AND KIDNEY FUNCTION TESTS IN THE ANIMAL MODEL OF STZ INDUCED DIABETES MELLITUS IN MALE RATS

Abstract

This study was conducted to observe the serum biochemical changes associated with Diabetes Mellitus, in the STZ induced Diabetic rats, treated with Nigella sativa, Cinnamon and ginger. The study was comprised of forty adult male wistar rats, divided into eight groups of five each. Group I Untreated rats, Group II Diabetic rats (Intra-venous injection of 60mg/kg dose of Streptozotocin), the positive control group. Group III Preventive Ginger.Group IV Preventive Cinnamon: Group V Preventive Nigella sativa. Group VI; Therapeutic Ginger Diabetic rats; received 10000 mg/kg BW/day of the ginger extract. Group VII Cinnamon Therapeutic, Diabetic rats; received cinnamon extract 400 mg/Kg body weight and Group VIII Nigella sativa Therapeutic received, 200 mg/kg Nigella sativa extract daily. The animal were treated for 3 weeks. The diabetic rats showed increase in serum glucose levels accompanied by increase in Kidney function test parameters like Urea, Creatinine and Cysteine C levels .The animals also exhibited increase in serum Total Cholesterol (TC) and Triglycerides (TG). At the same time reductions were observed in High Density Lipoprotein Cholesterol (HDL-C) levels. Ginger effectively decreased serum glucose levels and brought the above mentioned serum assays levels near to normal value. Histological examination of the pancreas of STZ given rats, which were treated with ginger showed almost normal structure, in comparison to untreated diabetic group. The results of the study show that treatment with aqueous extract of ginger may be efficacious in bringing down the increased serum glucose levels and dyslipidemias in diabetic rats.

The possible protective and therapeutic effects of ginger and cinnamon on the testis and coda epididymis of streptozotocin-induced-diabetic rats: Histological and biochemical studies

“…The present study revealed that cinnamon has a significant hypoglycemic supplement in both protective and therapeutic groups. Similar results were reported previously by Muhammad & Sangi (2018) and recently by Sivapriya & John (2020) . Similar results were also obtained by Sahib, 2016 , Costello et al, 2016 who found that cinnamon as 1gm/day-controlled blood sugar in diabetic patients.…”

“…In the present study, plasma glucose levels were considerably lower in both pre-and post-treatment groups who were given ginger water extract. Muhammad & Sangi (2018) reported that aqueous extract of ginger (500 mg/mL) results in an improvement of hyperglycemic status in diabetic rats. Elshater et al (2009) showed that ginger and its active ingredient; gingerol regulated glucose metabolism by decreasing glycogenolysis and gluconeogenesis with subsequent reductions in hepatic glucose production and blood glucose concentrations.…”

“…The aqueous extract was given orally via stomach gavage, in dose of ginger (500 mg/kg/bw/day), and Cinnamomum (50 mg/kg/bw/day). Rats of G 1 contained control rats; G2 rats, induced diabetic, G3 rats, treated with ginger before induction of DM (ginger protective) ( Al-Amin et al, 2006 ); G4 rats, were given ginger after DM induction (ginger therapeutic); G5 rats, were given cinnamon before induction of DM (cinnamon protective) ( Al-khamas, 2018 , Muhammad and Sangi, 2018 ); G6 rats, were given cinnamon after DM induction (cinnamon therapeutic).…”

“…Diabetes mellitus is characterized by hyperglycemia caused by impaired insulin production, insulin receptor sensitivity, or a combination of both ( Sangi, 2018 ) According to estimates of IDF, the number of diabetic patients is going to increase to 642 million by 2040 ( Sangi et al, 2018 , Ding et al, 2015 ).…”