Effects of nigella sativa supplementation on blood parameters and anthropometric indices in adults: A systematic review on clinical trials

Mohtashami, Alireza; Entezari, Mohammad Hasan

doi:10.4103/1735-1995.175154

Cited by 28 publications

(11 citation statements)

References 35 publications

(57 reference statements)

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“…Also, SBP and DBP were reduced significantly (by À8.0 and À4.3 mmHg in the intervention condition, respectively). A recent systematic review of clinical trials has assessed the impact of Nigella sativa on blood parameters and anthropometric indices (Mohtashami & Entezari, 2016), in which the effectiveness of Nigella sativa on weight, WC and blood pressure parameters was inconclusive.…”

Section: Resultsmentioning

confidence: 99%

Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: A randomized, double‐blind, placebo‐controlled clinical trial

Hadi

Daryabeygi-Khotbehsara

Mirmiran

et al. 2021

Phytotherapy Research

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The objective of this study was to determine the effects of Nigella sativa oil extract on cardiometabolic risk factors in people with type 2 diabetes (T2D). A randomized, controlled, clinical trial was conducted on 43 patients with T2D (23 women and 20 men; aged 53.5 ± 7.4 years). The intervention group (N = 23) received two 500-mg per day soft gel capsules containing Nigella sativa oil extract and the control group (N = 20) received two identical placebo soft gel capsules containing sunflower oil per day for the same period, 8 weeks. Pre-and post-intervention cardiometabolic risk factors were measured. Compared with the placebo, the N. sativa oil significantly decreased FBS (p = .03(, HbA1c (p = .001), total cholesterol (p = .04), TG (p = .003), LDL-c (p = .001), BMI (p < .001), waist circumference (p < .001), SBP (p = .001), and DBP (p = .002). HOMA-IR (p = .51) and HDL-c (p = .91) did not change significantly following Nigella sativa supplementation. Nigella sativa oil exerted beneficial effects on glycemic control, serum lipid profile, blood pressure, and body weight among people with T2D. Further long-term trials in the future may help confirm the current therapeutic benefits of Nigella sativa in T2D.

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Section: Resultsmentioning

confidence: 99%

Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: A randomized, double‐blind, placebo‐controlled clinical trial

Hadi

Daryabeygi-Khotbehsara

Mirmiran

et al. 2021

Phytotherapy Research

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“…In addition, improvement of lipoprotein profiles and mitigation of liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALK-P) took place in rats treated by the extract (Vedanarayanan and Krishnan, 2011). Thymoquinone (TQ) derived from the seeds and volatile oil of N. sativa has been suggested to be useful in blood glucose regulation and to ameliorate feeding disturbances (Mohtashami and Entezari, 2016). Uncoupling protein-1 (UCP-1) is an uncoupling molecule which disturbs the proton gradient in oxidative and phosphorylation in the mitochondria of brown adipose tissue (Dulloo et al, 2010).…”

Section: Effect Of N Sativa and Its Ingredient On Obesitymentioning

confidence: 99%

“…Thymoquinone (TQ) derived from the seeds and volatile oil of N. sativa has been suggested to be useful in blood glucose regulation and to ameliorate feeding disturbances ( Mohtashami and Entezari, 2016 ). Uncoupling protein-1 (UCP-1) is an uncoupling molecule which disturbs the proton gradient in oxidative and phosphorylation in the mitochondria of brown adipose tissue ( Dulloo et al, 2010 ).…”

Section: The Effects Of Medicinal Plants On Metabolic Disordersmentioning

confidence: 99%

Effects of Nigella sativa, Camellia sinensis, and Allium sativum as Food Additives on Metabolic Disorders, a Literature Review

2021

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Objective: Metabolic disorders (MD) can disturb intracellular metabolic processes. A metabolic disorder can be resulted from enzyme deficits or disturbances in function of various organs including the liver, kidneys, pancreas, cardiovascular system, and endocrine system. Some herbs were used traditionally for spices, food additives, dietary, and medicinal purposes. Medicinal plants possess biological active compounds that enhance human health. We aimed to provide evidence about therapeutic effects of some medicinal herbs on MD.Data Sources: PubMed, Scopus, and Google Scholar were explored for publications linked to MD until February 2021. The most literature reports that were published in the last 10 years were used. All types of studies such as animal studies, clinical trials, and in vitro studies were included. The keywords included “Metabolic disorders,” “Nigella sativa L.,” “Thymoquinone,” “White tea”OR “Camellia sinensis L.” “catechin,” and “Allium sativum L.” OR “garlic” were searched.Results: Based on the results of scientific studies, the considered medicinal plants and their active components in this review have been able to exert the beneficial therapeutic effects on obesity, diabetes mellitus and non-alcoholic fatty liver disease.Conclusions: These effects are obvious by inhibition of lipid peroxidation, suppression of inflammatory reactions, adjustment of lipid profile, reduction of adipogenesis and regulation of blood glucose level.

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“…sativa on obesity management (Mohtashami & Entezari, 2016;Namazi, Larijani, Ayati, & Abdollahi, 2018).…”

Section: Some Herbs and Their Active Compounds Can Reduce Weightmentioning

confidence: 99%

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

Payab

Hasani‐Ranjbar

Shahbal

et al. 2019

Phytotherapy Research

100

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Obesity is a medical situation in which excess body fat has gathered because of imbalance between energy intake and energy expenditure. In spite of the fact that the variety of studies are available for obesity treatment and management, its “globesity” still remains a big challenge all over the world. The current systematic review and meta‐analysis aimed to evaluate the efficacy, safety, and mechanisms of effective herbal medicines in the management and treatment of obesity and metabolic syndrome in human. We systematically searched all relevant clinical trials via Web of Science, Scopus, PubMed, and the Cochrane database to assess the effects of raw or refined products derived from plants or parts of plants on obesity and metabolic syndrome in overweight and obesity adult subjects. All studies conducted by the end of May 2019 were considered in the systematic review. Data were extracted independently by two experts. The quality assessment was assessed using Consolidated Standards of Reporting Trials checklist. The main outcomes were anthropometric indices and metabolic syndrome components. Pooled effect of herbal medicines on obesity and metabolic syndrome were presented as standardized mean difference (SMD) and 95% confidence interval (CI). A total of 279 relevant clinical trials were included. Herbals containing green tea, Phaseolus vulgaris, Garcinia cambogia, Nigella sativa, puerh tea, Irvingia gabonensis, and Caralluma fimbriata and their active ingredients were found to be effective in the management of obesity and metabolic syndrome. In addition, C. fimbriata, flaxseed, spinach, and fenugreek were able to reduce appetite. Meta‐analysis showed that intake of green tea resulted in a significant improvement in weight ([SMD]: −0.75 [−1.18, −0.319]), body mass index ([SMD]: −1.2 [−1.82, −0.57]), waist circumference ([SMD]: −1.71 [−2.66, −0.77]), hip circumference ([SMD]: −0.42 [−1.02, −0.19]), and total cholesterol, ([SMD]: −0.43 [−0.77, −0.09]). In addition, the intake of P. vulgaris and N. sativa resulted in a significant improvement in weight ([SMD]: −0.88, 95 % CI: [−1.13, −0.63]) and triglyceride ([SMD]: −1.67, 95 % CI: [−2.54, −0.79]), respectively. High quality trials are still needed to firmly establish the clinical efficacy of the plants in obesity and metabolic syndrome.

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Effects of nigella sativa supplementation on blood parameters and anthropometric indices in adults: A systematic review on clinical trials

Cited by 28 publications

References 35 publications

Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: A randomized, double‐blind, placebo‐controlled clinical trial

Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: A randomized, double‐blind, placebo‐controlled clinical trial

Effects of Nigella sativa, Camellia sinensis, and Allium sativum as Food Additives on Metabolic Disorders, a Literature Review

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

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