Effects of Nigella sativa fixed oil on blood homeostasis in rat

Zaoui, A; Cherrah, Yahia; Alaoui, Katim; Mahassine, N; Amarouch, Hamid; Hassar, Mohammed

doi:10.1016/s0378-8741(01)00342-7

Cited by 153 publications

(116 citation statements)

References 6 publications

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“…The seeds/oil have anti-inflammatory [15], analgesic [4], antipyretic [16], spasmolytic [17], bronchodialator [17], antihistaminic [18], antihypertensive [19], antitumor [20], antioxidant [18], antineoplastic [9,21,22], antifertility [23], antibacterial [24], antifungal [25], antiprotozoal [26], anthelmintic [27] and insecticidal [28] activities. Treatment of rats with the seed extract for up to 12 weeks has been reported to induce changes in the hemogram that include an increase in both the packed cell volume and hemoglobin [29] and a decrease in plasma concentrations of cholesterol, triglycerides and glucose [30]. The seeds of N. sativa are characterized by a very low degree of toxicity.…”

Section: Review and Discussionmentioning

confidence: 99%

“…In an experimental study, when fixed oil of N. sativa (1 ml/kg) was given for 12 weeks to normal rats, the serum glucose, cholesterol and triglycerides levels decreased by 16.5%, 15.5%, 22% compared to control values, respectively. In parallel, significant slowdown of the body weight evolution was observed in NSO treated animals as compared to the control group [30]. In addition to NSO, the defatted extract of N. sativa also increases glucose induced insulin release in isolated rat pancreatic islets in concentration-dependent manner [39].…”

Section: Antidiabetic Activity In Normal Ratsmentioning

confidence: 93%

“…However, an enzyme-inducing effect of N. sativa extract cannot be ruled out and repeated or long term use of N. sativa may therefore not be safe. There is also a need to monitor blood counts when N. sativa is given for longer period as NSO (1 ml/kg) given for 12 weeks, to normal rats decreased the counts of leukocytes and platelets [30].…”

Section: Clinical Studies On Human Beingsmentioning

confidence: 99%

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Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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Seeds of Nigella sativa (black cumin/kalonji) used in pickles as spice, have also been traditionally used in treatment of many diseases including diabetes and hypertension. Among many activities exhibited by N. sativa and its constituents in animal experiments, antidiabetic property is most important. Thymoquinone (TQ), a volatile oil, is one of its active constituents but antidiabetic activity has also been shown by its aqueous extract and defatted extract. N. sativa may be beneficial in diabetic individuals and those with glucose intolerance as it reduces appetite, glucose absorption in intestine, hepatic gluconeogenesis, blood glucose level, cholesterol, triglycerides, body weight and simulates glucose induced secretion of insulin from beta-cells in pancreas; improves glucose tolerance as efficiently as metformin; yet it has not shown significant adverse effects and has very low toxicity. In streptozotocin (STZ) induced diabetic rats it causes gradual partial regeneration of pancreatic beta-cells, increases the lowered serum insulin concentrations and decreases the elevated serum glucose. N. sativa has antioxidant activity and protective role of TQ against development of type I diabetes may be via NO inhibitory pathway. It also exerts an insulin-sensitizing action in hepatocytes. Seeds of N. sativa have been safely consumed by human patients in many clinical trials which however were not aimed to assess its antidiabetic activity. In future clinical studies may show potential of N. sativa, its constituents or their synthetic analogues, in prevention and control of diabetes.

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Section: Review and Discussionmentioning

confidence: 99%

Section: Antidiabetic Activity In Normal Ratsmentioning

confidence: 93%

Section: Clinical Studies On Human Beingsmentioning

confidence: 99%

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Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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“…Previous studies on rats reported that rats which received a daily administration of 1 mg/kg of NS oil had significantly lower body weight than a control group [8] . This finding shows that reduced body weight may be associated with TQinduced body weight loss in this group in the present study.…”

Section: Discussionmentioning

confidence: 85%

“…There isn't any meaningful difference when the FD+TQ group compared to the control group. According to the literature [8] , this result may be related to the effect of TQ which prevents weight gain.…”

Section: Discussionmentioning

confidence: 88%

Effects of Thymoquinone on Plasma Leptin, Insulin, Thyroid Hormones and Lipid Profile in Rats Fed A Fatty Diet

Güllü¹,

Avcı²

2013

Kafkas Univ Vet Fak Derg

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SummaryThe purpose of this study was to investigate the effects of thymoquinone (TQ) on plasma hormone levels, which regulate energy metabolism, and on the lipid profile of rats fed a standard and fatty diets. The study was performed on four experimental groups for 6 weeks using Wistar Albino rats weighing 200-260 g, aged 5-6 months, with 10 rats in each group. 1) The control group: Rats were fed a standard diet and given 1 ml 0.9% saline /kg body weight/day by gastric gavage.2) The TQ group: Rats were fed a standard diet and given 50 mg TQ/kg body weight/day dissolved in 1 ml 0.9% saline, by gastric gavage.3) The fatty diet (FD) group: Rats were fed an experimental diet containing 50% animal fat and given 1 ml 0.9% saline/kg body weight/day by gastric gavage. 4) The FD+TQ group: Rats were fed an experimental diet containing 50% animal fat and given 50 mg TQ/kg body weight/day dissolved in 1 ml 0.9% saline by gastric gavage. At the end of the experimental period, plasma insulin, thyroxine (T 4 ), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were significantly decreased in the TQ group compared with the control group while the plasma glucose level was increased (P<0.01). In the FD group compared to the control group, HDL and carnitine levels were significantly decreased while plasma leptin, glucose, total triiodothyronine (T 3 ), T 4 , free triiodothyronine (FT 3 ), free thyroxine (FT 4 ), trigliseride (TG), LDL and very low-density lipoprotein (VLDL) levels were significantly increased. Compared to the FD group, in particular, leptin, T 3 , FT 4 , TG, LDL and VLDL levels were significantly decreased in the FD+TQ group except for increased glucose. The study concludes that TQ may be a natural source for the provention of the harmful effects of a fatty diet, due to the dropped levels of leptin, TG, LDL, VLDL and could be considered for use in the field of preventive medicine.

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Characterization of phospholipid composition of black cumin (Nigella sativa L.) seed oil

Ramadan¹,

Mörsel

2002

Nahrung

104

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Black cumin (Nigella sativa L.) seed oil was extracted with two different solvents, n-hexane (H) and a mixture of chloroform/methanol (CM) (2:1, by volume). Amount of total lipid (TL) was higher in the CM miscelle (39.2% of seed fresh weight) than in the H extract (37.9%). Chemical characteristics as well as fatty acid profile of the TL extracts were compared and the analysis revealed that the major fatty acid was linoleic acid C18:2n-6 (ca. 57% of total fatty acid methyl esters (FAME)) followed by oleic acid C18:1n-9. Palmitic acid C16:0 was the major saturated fatty acid and detected in appreciable level. Chromatography on a silica column with solvent of increasing polarity yielded 96.1-97.2% neutral lipids (NL) and ca. 3% of polar lipids. Gas liquid chromatography with flame ionization detector (GLC/FID) showed that the major fatty acid present in all lipid classes was C18:2n-6 followed by C18:1n-9 and C16:0 acids, respectively. Phospholipid (PL) classes were separated via normal-phase HPLC. Separation was achieved on a silica column by gradient elution from isooctane/2-propanol (6:8, by volume) to isooctane/2-propanol/water (6:8:0.6, by volume) lasting 35 min with UV detection at 205 nm. The major individual PL classes were found to be phosphatidylcholine (PC; ca. 46-48% of total PL) followed by phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI), respectively. Phosphatidylglycerol (PG), lysophosphatidylethanolamine (LPE) and lysophosphatidylcholine (LPC) were isolated in smaller quantities. The level of saturated fatty acids, namely palmitic C16:0 and stearic C18:0 acids, was considerably higher in PL classes than in the corresponding triacylglycerols. Characterization of PL profile from Nigella sativa L. seed oil as well as the development of new source of PL was the primary aim of this study.

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Effects of Nigella sativa fixed oil on blood homeostasis in rat

Cited by 153 publications

References 6 publications

Antidiabetic Properties of a Spice Plant Nigella sativa

Antidiabetic Properties of a Spice Plant Nigella sativa

Effects of Thymoquinone on Plasma Leptin, Insulin, Thyroid Hormones and Lipid Profile in Rats Fed A Fatty Diet

Characterization of phospholipid composition of black cumin (Nigella sativa L.) seed oil

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