Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities

Lin, Yin Shiou; Chen, Sheng-Hsuan; Huang, Wei; Chen, Chao Hsiang; Chien, Mei Yin; Lin, Shyr Yi; Hou, Wen Chi

doi:10.1016/j.foodchem.2011.12.052

Cited by 35 publications

(17 citation statements)

References 28 publications

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“…NA by preventing lipid mobilization from tissues and consequent rise in plasma TG and free fatty acids (FFA) levels [ 29 , 30 , 42 ]. It also increases the plasma HDL levels and act as antioxidant when transformed into nicotinamide [ 28 , 43 – 45 ]. To our knowledge no such extensive study was performed in hyperlipidemia to demonstrate dose dependant effect invivo in combinational therapies of currently used antioxidants.…”

Section: Resultsmentioning

confidence: 99%

Synergistic combinatorial antihyperlipidemic study of selected natural antioxidants; modulatory effects on lipid profile and endogenous antioxidants

et al. 2016

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BackgroundHyperlipidemia, a major pathological condition associated with disrupted lipid levels and physiological redox homeostasis. The excessive release of reactive oxygen species (ROS) leads to enhanced lipid peroxidation, aggravated atherosclerosis and oxidative stress. Integration of natural antioxidant blends in alone or with conventional treatments can alleviate these issues synergistically contributing least side effects. Published literature reported the efficacy of natural antioxidants as individual and in combinations in various conditions but less data is available on their evaluation in low dose ratio blends particularly in hypercholesterolemic diet.MethodsAntihyperlipidemic effects of selected natural antioxidants; the phenolic oligomeric proanthocyanidins (OPC) and pterostilbene (PT) with niacin (NA) were investigated in current study. Their effects on lipid profile, lipid peroxidation and their aptitude to establish redox state between oxidants and antioxidants in body were evaluated in high cholesterol diet fed animal model. Male albino rabbits (n = 6) weighing 1.2–1.6 kg, supplemented with high cholesterol diet (400 mg/kg) for 12 weeks were used in the experiment. Antioxidants were administered individual high (100 mg/kg) and in low dose combinations (total dose = 100 mg/kg). Student’s t test and one way analysis of variance (ANOVA) followed by Dunnet’s test were used as statistical tools for evaluation.ResultsThe results showed synergistic effects of low dose antioxidant blends. Therapies retarded elevation in blood lipid levels, lipid peroxidation and blood antioxidant depletion and consequently contributed in reestablishing redox homeostasis. The LDL/HDL ratio and atherogenic index were suppressed significantly in blend therapies with maximum effects of 59.3 and 25 % (p >0.001) observed in 50:30:20 ratios of OPC, NA and PT, compared to individual therapies 37 and 18 % max respectively. Moreover the results were also in close proximity with the statin therapy (52.66, 26.28 %).ConclusionThis study provides an evidence for natural antioxidants blends superiority over individual therapy in chronic diseases like hyperlipidemia. Such therapies in human equivalent doses can help in mitigating chronic illnesses in general populations.

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Section: Resultsmentioning

confidence: 99%

Synergistic combinatorial antihyperlipidemic study of selected natural antioxidants; modulatory effects on lipid profile and endogenous antioxidants

et al. 2016

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“…Vitamin B3, one of the eight B-vitamins, is also known as nicotinate or niacin. This endogenous metabolite is an effective antioxidant that prevents oxidative damage [27]. In general, nicotinamide and nicotinate metabolites are frequently reported in Lactobacillus strains [28][29][30], while Lactococcus members were not known to produce these metabolites until now.…”

Section: Adhesion Ability Amino Acid and Nicotinate And Nicotinamidmentioning

confidence: 99%

Characterization of a potential probiotic bacterium Lactococcus raffinolactis WiKim0068 isolated from fermented vegetable using genomic and in vitro analyses

Jung¹,

Lee²,

Seo

et al. 2020

Preprint

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Background: Lactococcus members belonging to lactic acid bacteria are widely used as starter bacteria in the production of fermented dairy products. From kimchi, a Korean food made of fermented vegetables, Lactococcus raffinolactis WiKim0068 was isolated and its genome was analyzed. Results: The complete genome of the strain WiKim0068 consists of one chromosome and two plasmids that comprises 2,292,235 bp, with a G+C content of 39.7 mol%. Analysis of orthoANI values among Lactococcus genome sequences showed that the strain WiKim0068 has > 67% sequence similarity to other species and subspecies. In addition, it displayed no antibiotic resistance and can metabolize nicotinate and nicotinamide (vitamin B3). Conclusion: These results augments our understanding of the genus Lactococcus and suggest that this new strain has potential industrial applications.

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“…Vitamin B3, one of the eight B-vitamins, is also known as nicotinate or niacin. This endogenous metabolite is an effective antioxidant that prevents oxidative damage [22]. In general, nicotinamide and nicotinate metabolites are frequently reported in Lactobacillus strains [23][24][25], while Lactococcus members were not known to produce these metabolites until now.…”

Section: Amino Acid and Nicotinate And Nicotinamide Metabolismmentioning

confidence: 99%

Characterization of a potential probiotic bacterium Lactococcus raffinolactis WiKim0068 isolated from fermented vegetable using genomic and in vitro analyses

Jung¹,

Lee²,

Seo

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities

Cited by 35 publications

References 28 publications

Synergistic combinatorial antihyperlipidemic study of selected natural antioxidants; modulatory effects on lipid profile and endogenous antioxidants

Synergistic combinatorial antihyperlipidemic study of selected natural antioxidants; modulatory effects on lipid profile and endogenous antioxidants

Characterization of a potential probiotic bacterium Lactococcus raffinolactis WiKim0068 isolated from fermented vegetable using genomic and in vitro analyses

Characterization of a potential probiotic bacterium Lactococcus raffinolactis WiKim0068 isolated from fermented vegetable using genomic and in vitro analyses

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