Drugs Affecting Lipid Metabolism VIII 1985
DOI: 10.1007/978-1-4613-2459-1_22
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Effects of Nicotinic Acid and its Derivatives on Lipid Metabolism and Other Metabolic Factors Related to Atherosclerosis

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Cited by 9 publications
(7 citation statements)
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“…In addition to its function as a vitamin, nicotinic acid (NA; or niacin) has been used as a lipid-lowering drug for more than four decades (1, 2); NA treatment, at high doses, decreases LDL-cholesterol, triglycerides, and VLDL while increasing HDL-cholesterol (3, 4), and all of these effects are beneficial to the prevention of atherosclerosis. The lipid-lowering effects of NA have been traditionally attributed to its antilipolytic effect in adipocytes (5); NA binds to and stimulates a G-protein coupled receptor (i.e., NA receptor) in the plasma membrane of adipocytes to decrease cAMP and lipolysis, and decreased lipolysis in adipocytes reduces the supply of FFA for triglyceride synthesis and VLDL formation in the liver.…”
Section: Introductionmentioning
confidence: 99%
“…In addition to its function as a vitamin, nicotinic acid (NA; or niacin) has been used as a lipid-lowering drug for more than four decades (1, 2); NA treatment, at high doses, decreases LDL-cholesterol, triglycerides, and VLDL while increasing HDL-cholesterol (3, 4), and all of these effects are beneficial to the prevention of atherosclerosis. The lipid-lowering effects of NA have been traditionally attributed to its antilipolytic effect in adipocytes (5); NA binds to and stimulates a G-protein coupled receptor (i.e., NA receptor) in the plasma membrane of adipocytes to decrease cAMP and lipolysis, and decreased lipolysis in adipocytes reduces the supply of FFA for triglyceride synthesis and VLDL formation in the liver.…”
Section: Introductionmentioning
confidence: 99%
“…NA binds to and stimulates a G proteincoupled receptor [i.e., GPR109A or HM74A (37,41)] in the plasma membrane of adipocytes to decrease cAMP and lipolysis, which in turn reduces the plasma levels of FFA, substrates for hepatic TG synthesis, and VLDL formation. However, this classic view may need revision, because circulating FFA levels, which initially decrease during treatment, rebound after long-term NA treatment (see below), whereas its lipid-lowering effects persist (38). When this occurs, the hypolipidemic effects of NA cannot be explained by reduced FFA delivery to the liver.…”
mentioning
confidence: 99%
“…hypolipidemic drug; free fatty acids; perilipin; phosphodiesterase; triglyceride synthesis; insulin resistance; nicotinic acid receptor; microarray analysis NICOTINIC ACID (NA; or niacin) is a B-group vitamin. In addition to its function as a vitamin, NA, in high doses, has been used as a lipid drug for five decades (6, 21); it produces very desirable effects such as decreasing plasma triglycerides (TG), VLDL, and LDL-cholesterol levels and increasing HDL-cholesterol levels (14,38). Major clinical trials have demonstrated that NA treatment reduces the progression of atherosclerotic cardiovascular disease (9, 18).…”
mentioning
confidence: 99%
“…In contrast to fibrates, nicotinic acid exerts a larger effect on HDL 2 than HDL 3 [57][58][59]. Conversely these agents are less potent than fibrates in reducing triglyceride levels with reductions generally around 20%.…”
Section: Nicotinic Acid Derivativesmentioning
confidence: 84%