Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats
Khalil Hajiasgharzadeh,
Parviz Shahabi,
Elham Karimi-Sales
et al.
Abstract:Background
Nicotine, the main compound of smoking may exert its effects by changing the expression of microRNAs (miRNAs). This study was conducted to further investigate the molecular mechanisms of miRNA-dependent effects of nicotine in an animal model of liver fibrosis.
Methods
The bile duct ligation (BDL) approach was used to create a model of liver fibrosis. Twenty-four male Wistar rats were used in the study. The effects of nicotine administrat… Show more
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