Effects of nicotine cycling on weight loss and regain in male rats

Winders, Suzan E.; Wilkins, David R.; Rushing, Paul A.; Dean, Janice E.

doi:10.1016/0091-3057(93)90342-q

Cited by 2 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reductions in food intake and body weight seen in P. obesus in response to continuous nicotine infusion are consistent with previous literature in rodents [1–6]. However, P. obesus required close to double the infusion dose to achieve a similar degree of weight loss.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Nicotine treatment decreases food intake and body weight viaa leptin‐independent pathway in Psammomys obesus

Sanigorski

Fahey

Cameron‐Smith

et al. 2002

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

It has been reported previously that leptin may be involved in nicotine's ability to reduce body weight. Our aim was to investigate whether the anorexic action of nicotine is related to the actions of leptin by utilizing lean leptin-sensitive and obese leptin-resistant Psammomys obesus. Lean and obese P. obesus were assigned to receive nicotine sulphate at 6, 9 or 12 mg/day or saline (control) for 9 days (n = 6-10 in each group), administered using mini-osmotic pumps. Food intake, body weight, plasma leptin concentrations, plasma insulin and blood glucose were measured at baseline and throughout the study period. Nicotine treatment reduced food intake by up to 40% in lean and obese P. obesus. Plasma leptin levels fell significantly only in lean nicotine-treated animals, whereas no changes were observed in obese nicotine-treated animals. However, both lean and obese nicotine-treated animals had similar reductions in body weight. Our results show that nicotine has dramatic effects on food intake and body weight, however, these changes appear to be independent of the leptin signalling pathway.

show abstract

Section: Discussionsupporting

confidence: 89%

“…Numerous studies have demonstrated an inverse relationship between tobacco smoking and body weight [1–6]. This action of smoking appears to be nicotine‐mediated as indicated by Hajek et al .…”

Section: Introductionmentioning

confidence: 99%