Effects of Nicotine Administration in an Enriched Environment on the Behavior of Male MK-801-Exposed Rats
Neda Salmani,
Fatemeh Darvishzadeh Mahani,
Mahdieh Parvan
et al.
Abstract:Background: Smoking is more common in patients with schizophrenia than in healthy populations. Some controversial hypotheses connect the disease with the high prevalence of smoking. Moreover, environmental factors affect the severity of the positive and negative symptoms of schizophrenia. The current study aimed to assess the effect of enriched environment (EE) and nicotine on the MK-801 animal model of schizophrenia. Methods: Male Wistar rat pups randomly received saline or MK-801 (dose:1 mg/kg) for five days… Show more
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