Effects of Nicardipine HCl on Serum Lipids and Blood Pressure

Ishida, Nobuhiko; Matsuo, Ryuji; Migita, Toshimasa; Tanaka, Yasuo; Fujimoto, Takashi; Baba, Yoshiyuki; Inoue, Tomio; Satoh, Hideaki; Satoh, Yoshihiko; Tohno, Toshio

doi:10.5551/jat1973.12.4_833

Cited by 2 publications

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“…Although the number of reports are limited, the calcium channel blockers nifedipine [13][14][15], diltiazem [14,16], verapamil [17,18], nicardipine [19], and nitrendipine [20] showed no adverse effect on serum lipoprotein metabolism. Among the effects of diltiazem on lipoproteins, Schulte et al showed [14] a decrease in LDL cholesterol and Pool et al showed [16] an increase in HDL cholesterol levels after diltiazem.…”

Section: Discussionmentioning

confidence: 99%

A multicenter comparison of nicorandil and diltiazem on serum lipid, apolipoprotein, and lipoprotein levels in patients with ischemic heart disease

Sasaki

Saeki

Kawasaki³

et al. 1992

Cardiovasc Drug Ther

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The effects of nicorandil and diltiazem on serum lipid, apolipoprotein, and lipoprotein levels in 37 patients with ischemic heart disease were examined in a randomized, multicenter study. Nicorandil (n = 20, 10-40 mg/day, b.i.d.) and diltiazem (n = 17, 60-240 mg/day, b.i.d.) were administered for 12 weeks. Both nicorandil and diltiazem administration showed an effective antianginal effect. Diltiazem administration showed a significant hypotensive action. There were no significant changes in serum lipids, apolipoproteins, and lipoproteins for both nicorandil and diltiazem. There were no significant changes in body weight, uric acid, and fasting blood sugar levels during the test period for both drugs. These data show that nicorandil, like diltiazem, does not have any adverse effects on lipid metabolism and that it is a favorable drug to use as an agent for treating arteriosclerotic heart disease.

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Section: Discussionmentioning

confidence: 99%

A multicenter comparison of nicorandil and diltiazem on serum lipid, apolipoprotein, and lipoprotein levels in patients with ischemic heart disease

Sasaki

Saeki

Kawasaki³

et al. 1992

Cardiovasc Drug Ther

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Effects of short- and long-term administration of nifedipine on serum lipoprotein metabolism in patients with mild hypertension

Sasaki

Arakawa

1990

Cardiovasc Drug Ther

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The effects of short- and long-term administration of nifedipine on serum lipids, lipoproteins, and apolipoproteins (apo) were studied. Administration of nifedipine capsule for 4 months significantly decreased triglycerides and increased the HDL2 cholesterol and the HDL2/HDL3 cholesterol ratio. No significant changes in serum lipids and lipoproteins were observed during short-term therapy with slow-release nifedipine tablets. Following administration of tablets for 24 months, the LDL/HDL cholesterol ratio, apo B, and apo B/apo A-I ratio increased at 12 months, but reverted to baseline values at 24 months. Apo E levels were decreased significantly at 24 months. No significant changes were noted in total cholesterol, triglyceride, HDL cholesterol, HDL2,3 cholesterol, apo A-I, apo A-II, apo C-II, or apo C-III levels during long-term therapy with slow-release nifedipine tablets. These results indicate that nifedipine has a neutral or even favorable effect on lipoprotein metabolism. However, a prospective well-controlled study would be required to finally establish this effect. This finding strengthens the indications for using nifedipine as a first-line drug in the long-term treatment of hypertension.

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Effects of Nicardipine HCl on Serum Lipids and Blood Pressure

Cited by 2 publications

References 0 publications

A multicenter comparison of nicorandil and diltiazem on serum lipid, apolipoprotein, and lipoprotein levels in patients with ischemic heart disease

A multicenter comparison of nicorandil and diltiazem on serum lipid, apolipoprotein, and lipoprotein levels in patients with ischemic heart disease

Effects of short- and long-term administration of nifedipine on serum lipoprotein metabolism in patients with mild hypertension

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