Effects of neuromedin U on the pulsatile LH secretion in ovariectomized rats in association with feeding conditions

Quan, Hong; Funabashi, Toshiya; Furuta, Miyako; Kimura, Fukuko

doi:10.1016/j.bbrc.2003.10.052

Cited by 17 publications

(22 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To gain further insight into the physiological roles of NMU as putative regulator of the gonadotropic axis, we report herein a comprehensive series of analyses on the hypothalamic expression of NMU gene and LH responses to central injection of the neuropeptide in different functional states of the reproductive axis in the female rat. Contrary to previous observations in extreme experimental conditions (13,36,37), our data are the first to disclose a predominant stimulatory role of NMU in the control of LH secretion, a phenomenon that is coupled to the dynamic regulation of hypothalamic NMU gene expression by number of "reproductive" variables, such as the stage of sexual maturation, the phase of the ovarian cycle, the input of sex steroids, and photic cues with clear-cut influences on the gonadotropic axis.…”

contrasting

confidence: 52%

“…On these premises, the ability of NMU to modulate gonadotropin (LH) secretion and puberty has been previously, albeit scarcely, explored in rodents (13,36,37). Yet, such initial analyses were conducted mostly in rather unphysiological settings, such as the ovariectomized (OVX) rat and the constitutive NMU-null mouse, where, despite it being a satiety signal putatively activated in conditions of energy abundance, a counterintuitive effect of NMU as inhibitor of LH secretion and puberty onset has been suggested (13,36,37). To gain further insight into the physiological roles of NMU as putative regulator of the gonadotropic axis, we report herein a comprehensive series of analyses on the hypothalamic expression of NMU gene and LH responses to central injection of the neuropeptide in different functional states of the reproductive axis in the female rat.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod

Vigo

Roa²,

Pineda³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

E, Pinilla L, Tena-Sempere M. Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod. Am J Physiol Endocrinol Metab 293: E1265-E1273, 2007. First published August 28, 2007; doi:10.1152/ajpendo.00425.2007.-Neuromedin U (NMU) is a widely spread neuropeptide, with predominant expression at the gastrointestinal tract and brain, putatively involved in the regulation of a diversity of biological functions, including food intake, energy balance and circadian rhythms; all closely related to reproduction. Yet, the implication of NMU in the control of the gonadotropic axis remains scarcely studied. We report herein analyses on the hypothalamic expression and function of NMU in different physiological and experimental states of the rat reproductive system. Expression of NMU mRNA at the hypothalamus was persistently detected along female postnatal development, with maximum levels in adulthood that fluctuated across the cycle and were modulated by ovarian steroids. Acute central administration of NMU evoked increases of serum LH levels in pubertal female rats, while repeated injection of NMU tended to advance vaginal opening. Likewise, central injection of NMU increased serum LH concentrations in cycling female rats, with peak responses in estrus. In contrast, NMU significantly inhibited preelevated LH secretion in gonadectomized and kisspeptin-treated rats. Finally, in noncycling females due to photoperiodic manipulation (constant light), hypothalamic NMU mRNA levels were markedly depressed, but relative LH responses to exogenous NMU were significantly augmented. All together, our present data support a predominant stimulatory role of NMU in the control of the female gonadotropic axis, which appears under the influence of developmental, hormonal, and photoperiodic cues, and might contribute to the joint regulation of energy balance, biological rhythms, and reproduction. neuromedin S; luteinizing hormone; estrous cycle; estrogen; progesterone; puberty; photoperiod; suprachiasmatic nucleus; rat NEUROMEDIN U (NMU) was originally identified in the porcine spinal cord (26), and later demonstrated as a highly conserved neuropeptide found in a diversity of species, including mammals, amphibians and birds (3). Distribution of NMU has been reported as relatively ubiquitous, with prominent expression in the gastrointestinal tract, pituitary and hypothalamus; the latter including the dorsomedial, arcuate (ARC) and suprachiasmatic (SCN) nuclei (2, 3, 15). The biological actions of NMU are conducted through interaction with two different G proteincoupled receptors: FM-3/GPR66, also known as NMU receptor type-1 (NMU1R), and FM4/TGR-1 or NMU receptor type 2 (NMU2R) (12,18,19,23,39,40). Interestingly, NMU1R and NMU2R show rather distinct patterns of distribution: NMU1R is expressed in a variety of peripheral tissues, such as intestine, testis, pancreas, uterus, lung, and kidney, whereas NMU2R is selectively detected in discrete brain areas such as the parav...

show abstract

contrasting

confidence: 52%

mentioning

confidence: 99%

Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod

Vigo

Roa²,

Pineda³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…administration in ovariectomized rats (108 ). This effect was mediated by CRH (109 ), and it was further shown that NmU inhibited the release of LH and FSH from pituitary cells in vitro, while NmU Ϫ/Ϫ mice display signs of puberty at an earlier age than their wild-type counterparts (110 ).…”

Section: Hormone Releasementioning

confidence: 99%

Neuromedin U: A Multifunctional Neuropeptide with Pleiotropic Roles

2015

View full text Add to dashboard Cite

BACKGROUND Neuromedin U (NmU) belongs to the neuromedin family, comprising a series of neuropeptides involved in the gut–brain axis and including neuromedins B and C (bombesin-like), K (neurokinin B), L (neurokinin A or neurotensin), N, S, and U. CONTENT Although initially isolated from porcine spinal cord on the basis of their ability to induce uterine smooth muscle contraction, these peptides have now been found to be expressed in several different tissues and have been ascribed numerous functions, from appetite regulation and energy balance control to muscle contraction and tumor progression. NmU has been detected in several species to date, particularly in mammals (pig, rat, rabbit, dog, guinea pig, human), but also in amphibian, avian, and fish species. The NmU sequence is highly conserved across different species, indicating that this peptide is ancient and plays an important biological role. Here, we summarize the main structural and functional characteristics of NmU and describe its many roles, highlighting the jack-of-all-trades nature of this neuropeptide. SUMMARY NmU involvement in key processes has outlined the possibility that this neuropeptide could be a novel target for the treatment of obesity and cancer, among other disorders. Although the potential for NmU as a therapeutic target is obvious, the multiple functions of this molecule should be taken into account when designing an approach to targeting NmU and/or its receptors.

show abstract

“…However, the physiological consequences of these effects remain to be established (see also Section V.D.). Based on studies in which NmU was delivered intracerebroventricularly to ovariectomized rats, it has also been argued that NmU inhibits the release of luteinizing hormone through a CRH-mediated inhibition of pulsatile gonadotropin-releasing hormone release from pituitary gonadotropes (Quan et al, 2003).…”

Section: Hypothalamo-pituitary-adrenal Axis and The Stress Responsementioning

confidence: 99%

Neuromedin U and Its Receptors: Structure, Function, and Physiological Roles

Brighton

Szekeres²,

Willars³

2004

Pharmacol Rev

244

219

View full text Add to dashboard Cite

Effects of neuromedin U on the pulsatile LH secretion in ovariectomized rats in association with feeding conditions

Cited by 17 publications

References 42 publications

Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod

Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod

Neuromedin U: A Multifunctional Neuropeptide with Pleiotropic Roles

Neuromedin U and Its Receptors: Structure, Function, and Physiological Roles

Contact Info

Product

Resources

About