Effects of Neuroleptics, Ethanol, Hypnotic-Sedatives, Tranquilizers, Narcotics, and Minor Stimulants in Aversive Paradigms

Bignami, Giorgio

doi:10.1007/978-1-4684-2394-5_7

Cited by 46 publications

(10 citation statements)

References 290 publications

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“…1980;Agmo & Avila, 1984), 2. avoidance reaction (Bignami, 1978) and agression (fighting, attack and defensive postures) produced by electric shock (Antelman & Caggiula, 1977) or stiniulus conditioned to shock (Niemegeers, Verbruggen & Jenssen, 1969), eating 1980;Agmo & Avila, 1984), 2. avoidance reaction (Bignami, 1978) and agression (fighting, attack and defensive postures) produced by electric shock (Antelman & Caggiula, 1977) or stiniulus conditioned to shock (Niemegeers, Verbruggen & Jenssen, 1969), eating …”

Section: Discussionmentioning

confidence: 99%

Dopaminergic Involvement in Nociceptive Sensitivity/Behavioral Reactivity Regulation During Aversive States of Different Nature in the Rat

Kiyatkin

1989

International Journal of Neuroscience

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To investigate the involvement of dopamine (DA) in nociceptive sensitivity-behavioral reactivity regulation in animals during aversive states of different nature, the influence of pharmacologically-induced decrease and increase of DA neurotransmission on vocalization and movement reactivity were studied in rats in free behavior, during restraint stress, after acute trauma of an extremity and under intraperitoneal acetic acid administration. The influence of longterm increase (apomorphine in a high dose) and decrease (haloperidol, apomorphine in a low dose) on suprarenals weight and gastric ulceration in animals exposed by polymodal aversive stimulation was also studied. The data obtained are discussed in relation with; 1. DA involvement in regulation of nociceptive sensitivity and behavioral reactivity in aversive environment; 2. the role of DA and endogenous opioid peptides in endogenous analgesic mechanisms; 3. the functional significance of cerebral DA in organization and realization of various types of an organism's adaptive activity produced by different environmental and homeostatic variables; and 4. the interaction of DA and endogenous opioid peptides in mediation of this activity.

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Section: Discussionmentioning

confidence: 99%

Dopaminergic Involvement in Nociceptive Sensitivity/Behavioral Reactivity Regulation During Aversive States of Different Nature in the Rat

Kiyatkin

1989

International Journal of Neuroscience

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“…The treatment of antipsychotic drugs selectively disrupts avoidance responding without altering unconditioned escape response [13, 14], and thus this test has high predictive validity for antipsychotic efficacy [15]. This feature has been effectively used to identify potential antipsychotic drugs, to differentiate antipsychotic drugs from other classes of psychotropic drugs, and to predict the clinical potency of antipsychotic drugs [11, 14, 16-18]. Our work focuses on behavioral characteristics and neurobiological mechanisms of antipsychotic sensitization in the conditioned avoidance response (CAR) and phencyclidine (PCP)-induced hyperlocomotion models, two animal behavioral tests sensitive to antipsychotic activity [8, 19-23].…”

Section: Introductionmentioning

confidence: 99%

Time-dependence of risperidone and asenapine sensitization and associated D2 receptor mechanism

Gao

Li²

2013

Behavioural Brain Research

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When an antipsychotic drug is given repeatedly and intermittently, there is often a long-term increase in its behavioral efficacy, termed antipsychotic sensitization. With the passage of time, the magnitude of antipsychotic sensitization may increase or decrease depending on the principle of Time-Dependent Sensitization (TDS) or memory decay, respectively. In the present study, we examined the time-dependent feature and possible dopamine D2 receptor mechanism of sensitization induced by the antipsychotics risperidone and asenapine in the conditioned avoidance response test. Well-trained male adult Sprague-Dawley rats were first repeatedly treated with risperidone (1.0 mg/kg) or asenapine (0.2 mg/kg) and tested for avoidance response daily for 5 consecutive days. Eight, 18 or 38 days after the 5th drug treatment, all rats were retested drug-free to assess the residual impact of prior risperidone or asenapine treatment. Drug-pretreated rats had significantly lower avoidance than vehicle-pretreated ones on this test, and the group differences increased with the passage of time. In the subsequent drug challenge test at 10, 20 or 40 days after the 5th drug treatment, all rats were injected with a low dose of risperidone (0.3 mg/kg) or asenapine (0.1 mg/kg). Drug-pretreated rats again made significantly less avoidances than controls, confirming the drug-induced sensitization effect. Finally, in the quinpirole (a D2/3 receptor agonist, 1.0 mg/kg, sc)-induced hyperlocomotion test, risperidone-pretreated rats exhibited a significantly higher level of motor activity than the vehicle-pretreated ones. These findings suggest that risperidone and asenapine sensitization is long-lasting, follows the TDS principle, and is likely mediated by D2 receptor supersensitivity.

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“…footshock). This feature has been effectively used to identify potential antipsychotic drugs, to differentiate antipsychotic drugs from other classes of psychotropic drugs, and to predict the clinical potency of antipsychotic drugs and (Arnt, 1982, Bignami, 1978, Cook and Davidson, 1978, Janssen et al, 1965, Kuribara and Tadokoro, 1981, Shannon et al, 1999, van der Heyden and Bradford, 1988, Wadenberg and Hicks, 1999). Therefore, understanding the nature of antipsychotic-induced avoidance disruption may shed light on the behavioral and neurobiological mechanisms of antipsychotic action in the treatment of psychosis.…”

Section: Introductionmentioning

confidence: 99%

Olanzapine and risperidone disrupt conditioned avoidance responding by selectively weakening motivational salience of conditioned stimulus: Further evidence

Zhang¹,

Fang²,

Li³

2011

Pharmacology Biochemistry and Behavior

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Suppression of conditioned avoidance response is a preclinical behavioral index of antipsychotic activity. Previous work shows that olanzapine and risperidone disrupt avoidance response elicited by a less salient conditioned stimulus (CS2) to a greater extent than avoidance elicited by a more salient stimulus (CS1), suggesting that antipsychotic drugs may have a weakening action on motivational salience of stimuli. In the present study, we further examined this mechanism of antipsychotic action, focusing on the possible impact of baseline difference of CS1 and CS2 response rates on the avoidance-disruptive effect of olanzapine and risperidone. Rats were first trained to acquire avoidance responding in a procedure in which the number of CS2 trials (i.e. 20) was twice the number of CS1 trials (i.e. 10), but the percentage of CS2-shock pairing was set at 25 % lower (15 trials out of 20) than the percentage of CS1-shockpairing ( 20 trials out of 20). They were then tested daily under olanzapine (0.5 and 1.0 mg/kg, sc) or risperidone (0.33 and 1.0 mg/ kg, sc) for 5 consecutive days. Repeated olanzapine and risperidone treatment dose-dependently disrupted avoidance responding to both CS1 and CS2.B oth drugs at the high dose disrupted the CS2 avoidance to a greater extent than the CS1 avoidance. In the final challenge test, rats previously treated with olanzapine were tested under risperidone (0.33 mg/kg), whereas rats previously treated with risperidone were tested under olanzapine (0.5 mg/kg). Results show that rats previously treated with risperidone1.0 mg/kg group made significantly fewer avoidance responses than the vehicles under olanzapine at 0.5 mg/kg. These findings confirm that olanzapine and risperidone disrupt avoidance response primarily by selectively attenuating the motivational salience of the CS. The present study also suggests that there is a generality of antipsychotic drug experience that is mediated by a shared interoceptive drug state mechanism.

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Effects of Neuroleptics, Ethanol, Hypnotic-Sedatives, Tranquilizers, Narcotics, and Minor Stimulants in Aversive Paradigms

Cited by 46 publications

References 290 publications

Dopaminergic Involvement in Nociceptive Sensitivity/Behavioral Reactivity Regulation During Aversive States of Different Nature in the Rat

Dopaminergic Involvement in Nociceptive Sensitivity/Behavioral Reactivity Regulation During Aversive States of Different Nature in the Rat

Time-dependence of risperidone and asenapine sensitization and associated D2 receptor mechanism

Olanzapine and risperidone disrupt conditioned avoidance responding by selectively weakening motivational salience of conditioned stimulus: Further evidence

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