Effects of Neurofeedback on Panic Disorder Patients’ anxiety

Lü, Yan; Wang, Chunmei; Su, Lingjin; Ma, Zhiwen; Li, Sijin; Fan, Yulan

doi:10.14704/nq.2017.15.3.1083

Cited by 2 publications

(1 citation statement)

References 18 publications

(21 reference statements)

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“…Anxiety disorders are the most prevalent mental disorders and are associated with immense healthcare costs and a high burden of disease (Lu et al 2017). Continued excessive worry, difficulty concentrating, sleep abnormalities, emotional lability, fatigue, and restlessness are significant clinical manifestations in patients with anxiety (Blaskovits et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Sensorimotor rhythm neurofeedback training relieves anxiety in healthy people

et al. 2021

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Timely relief of anxiety in healthy people is important, but there is little research on this topic at present. Neurofeedback training allows subjects to regulate their specific brain activities autonomously and thus alter their corresponding cognitive functions. Inattention is a significant cognitive deficit in patients with anxiety. Sensorimotor rhythm (SMR) was reported to be closely related to attention. In this study, trainability, frequency specificity, and brain-behavior relationships were utilized to verify the validity of a relative SMR power protocol. An EEG neurofeedback training system was developed for alleviating anxiety levels in healthy people. The EEG data were collected from 33 subjects during SMR up-training sessions. Subjects attended six times neurofeedback training for about 2 weeks. The feedback value of the neurofeedback group was the relative SMR power at the feedback electrode (electrode C3), while the feedback values for the control group were pseudorandom numbers. The trainability index revealed that the learning trend showed an increase in SMR power activity at the C3 electrode, confirming effects across training. The frequency specificity index revealed only that SMR band activity increased significantly in the neurofeedback group. The brain-behavior relationships index revealed that increased SMR activity correlated negatively with the severity of anxiety. This study indicates that neurofeedback training using a relative SMR power protocol, based on activity at the C3 electrode, could relieve anxiety levels for healthy people and increase the SMR power. Preliminary studies support the feasibility and efficacy of the relative SMR power protocol for healthy people with anxiety.

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Section: Introductionmentioning

confidence: 99%

Sensorimotor rhythm neurofeedback training relieves anxiety in healthy people

et al. 2021

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Infraslow closed-loop brain training for anxiety and depression (ISAD): a protocol for a randomized, double-blind, sham-controlled pilot trial in adult females with internalizing disorders

Perez

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Adhia

et al. 2022

Trials

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Background The core intrinsic connectivity networks (core-ICNs), encompassing the default-mode network (DMN), salience network (SN) and central executive network (CEN), have been shown to be dysfunctional in individuals with internalizing disorders (IDs, e.g. major depressive disorder, MDD; generalized anxiety disorder, GAD; social anxiety disorder, SOC). As such, source-localized, closed-loop brain training of electrophysiological signals, also known as standardized low-resolution electromagnetic tomography (sLORETA) neurofeedback (NFB), targeting key cortical nodes within these networks has the potential to reduce symptoms associated with IDs and restore normal core ICN function. We intend to conduct a randomized, double-blind (participant and assessor), sham-controlled, parallel-group (3-arm) trial of sLORETA infraslow (<0.1 Hz) fluctuation neurofeedback (sLORETA ISF-NFB) 3 times per week over 4 weeks in participants (n=60) with IDs. Our primary objectives will be to examine patient-reported outcomes (PROs) and neurophysiological measures to (1) compare the potential effects of sham ISF-NFB to either genuine 1-region ISF-NFB or genuine 2-region ISF-NFB, and (2) assess for potential associations between changes in PRO scores and modifications of electroencephalographic (EEG) activity/connectivity within/between the trained regions of interest (ROIs). As part of an exploratory analysis, we will investigate the effects of additional training sessions and the potential for the potentiation of the effects over time. Methods We will randomly assign participants who meet the criteria for MDD, GAD, and/or SOC per the MINI (Mini International Neuropsychiatric Interview for DSM-5) to one of three groups: (1) 12 sessions of posterior cingulate cortex (PCC) ISF-NFB up-training (n=15), (2) 12 sessions of concurrent PCC ISF up-training and dorsal anterior cingulate cortex (dACC) ISF-NFB down-training (n=15), or (3) 6 sessions of yoked-sham training followed by 6 sessions genuine ISF-NFB (n=30). Transdiagnostic PROs (Hospital Anxiety and Depression Scale, HADS; Inventory of Depression and Anxiety Symptoms – Second Version, IDAS-II; Multidimensional Emotional Disorder Inventory, MEDI; Intolerance of Uncertainty Scale – Short Form, IUS-12; Repetitive Thinking Questionnaire, RTQ-10) as well as resting-state neurophysiological measures (full-band EEG and ECG) will be collected from all subjects during two baseline sessions (approximately 1 week apart) then at post 6 sessions, post 12 sessions, and follow-up (1 month later). We will employ Bayesian methods in R and advanced source-localisation software (i.e. exact low-resolution brain electromagnetic tomography; eLORETA) in our analysis. Discussion This protocol will outline the rationale and research methodology for a clinical pilot trial of sLORETA ISF-NFB targeting key nodes within the core-ICNs in a female ID population with the primary aims being to assess its potential efficacy via transdiagnostic PROs and relevant neurophysiological measures. Trial registration Our study was prospectively registered with the Australia New Zealand Clinical Trials Registry (ANZCTR; Trial ID: ACTRN12619001428156). Registered on October 15, 2019.

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Effects of Neurofeedback on Panic Disorder Patients’ anxiety

Cited by 2 publications

References 18 publications

Sensorimotor rhythm neurofeedback training relieves anxiety in healthy people

Sensorimotor rhythm neurofeedback training relieves anxiety in healthy people

Infraslow closed-loop brain training for anxiety and depression (ISAD): a protocol for a randomized, double-blind, sham-controlled pilot trial in adult females with internalizing disorders

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