Effects of Neonatal Hypoxic-Ischemic Injury on Brain Sterol Synthesis and Metabolism
Amanda M. Dave,
Ned A. Porter,
Zeljka Korade
et al.
Abstract:Background Neonatal hypoxic-ischemic brain injury (HIBI) results from disruptions to blood supply and oxygen in the perinatal brain. The goal of this study was to measure brain sterol metabolites and plasma oxysterols after injury in a neonatal HIBI mouse model to assess for potential therapeutic targets in the brain biochemistry as well as potential circulating diagnostic biomarkers.
Methods Postnatal day 9 CD1-IGS mouse pups were randomized to HIBI induced by carotid artery ligation followed by 30 … Show more
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