Effects of neonatal handling on basal and stress-induced monoamine levels in the male and female rat brain

Papaioannou, Andriana; Dafni, Urania; Alikaridis, F.; Bolaris, Stamatis; Stylianopoulou, Fotini

doi:10.1016/s0306-4522(02)00129-x

Cited by 77 publications

(48 citation statements)

References 59 publications

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“…In addition, 5-HT is implicated in the emergence of many neuropsychiatric disorders, including mental retardation, autism, depression and anxiety [10,15,[21][22][23][24][25][26]. Importantly, 5-HT signalling is influenced by numerous epigenetic and genetic factors, including nutrition and gut microbiota [27,28], perinatal stress [29][30][31], infection and inflammation [32][33][34][35], 5-HT metabolism and storage [15,[36][37][38], pharmacological compounds such as selective serotonin reuptake inhibitors [38][39][40] and genetic alterations [41][42][43][44].…”

Section: Introductionmentioning

confidence: 99%

Sculpting Cerebral Cortex with Serotonin in Rodent and Primate

Vitalis¹,

Verney²

2017

Serotonin - A Chemical Messenger Between All Types of Living Cells

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The mammalian cerebral cortex is critical for sensory and motor integrations and, for higher-order cognitive functions. The construction of mammalian cortical circuits involves the coordinated interplay between cellular processes such as proliferation, migration and differentiation of neural and glial cell subtypes followed by accurate connectivity evolving in complexity in primates. Alteration in cortical development may induce the emergence of various pathological traits and behaviours. Among the large array of factors that regulate the assembly of cortical circuits, serotonin (5-HT) plays important role as a developmental signal that impacts on a broad diversity of cellular processes. 5-HT plays distinct roles during specific sensitive periods and is produced from various sources depending on the perinatal stage. Its roles are mediated by more than fourteen 5-HT receptors that are all G-protein coupled receptors except the ionotropic 5-HT type 3A receptor (5-HT 3A ) mediating rapid neuronal activation. Importantly, 5-HT metabolism and signalling are influenced by numerous epigenetic and genetic factors, including nutrition and gut microbiota, perinatal stress, infection and inflammation. In this review, we will recapitulate some evidences showing that dysregulation of 5-HT homeostasis and 5-HT 3A signalling impairs distinct steps of cortical circuit formation leading to the predisposition of the onset of various psychiatric diseases.

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Section: Introductionmentioning

confidence: 99%

Sculpting Cerebral Cortex with Serotonin in Rodent and Primate

Vitalis¹,

Verney²

2017

Serotonin - A Chemical Messenger Between All Types of Living Cells

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“…Neonatal handling was performed as previously described [13][14]23] for 15 min daily between 09: 00 and 10: 00 h from postnatal day 1 until weaning (day 22).…”

Section: Neonatal Handlingmentioning

confidence: 99%

“…Animals, at 3 months of age, were subjected to repeated forced swimming stress for 15 consecutive days as previously described [13][14]23] . Plasma corticosterone and brain monoamine levels were determined immediately following the last exposure to the repeated forced swimming stress on day 15.…”

Section: Repeated Forced Swimming Stressmentioning

confidence: 99%

“…Neonatal handling has been shown to affect females differently than males [9,[13][14][15][16] . However, the mechanisms underlying the sexual dimorphic effects of neonatal handling remain elusive.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, we determined the effects of neonatal handling and androgenization on brain serotonin and dopamine levels, as well as their turnover, since previous results from our laboratory have shown that handling affects the serotonergic and dopaminergic system in a genderdependent way under basal conditions and after shortterm forced swimming stress [13] . Furthermore, the serotonergic and dopaminergic systems are involved in HPA axis regulation and the etiopathogenesis of depression [20,21] .…”

Section: Introductionmentioning

confidence: 99%

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Neonatal Handling and Gender Modulate Brain Monoamines and Plasma Corticosterone Levels following Repeated Stressors in Adulthood

Panagiotaropoulos

Pondiki²,

Papaioannou³

et al. 2004

Neuroendocrinology

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Neonatal handling affects the response to repeated stress in a sexually dimorphic manner. In order to elucidate the mechanisms underlying these gender-dependent effects, we investigated the consequences of neonatal androgenization and handling on adult stress reactivity by determining: (a) immobility time during repeated forced swimming, (b) plasma corticosterone levels, and (c) brain serotonin and dopamine levels and turnover after either repeated forced swimming, or repeated forced swimming followed by repeated restraint stress. In neonatally androgenized females, immobility time was lower in the handled than in the non-handled rats, a pattern resembling that of the males, suggesting that the sexually dimorphic effect of handling on immobility time can be attributed to the organizational effects of testosterone. No differences were found between androgenized females and females injected neonatally with vehicle, indicating that the gender differences in circulating corticosterone are not due to the organizational effects of testosterone. The stress of a neonatal injection interacted with neonatal handling resulting in lower plasma corticosterone and hypothalamic dopamine and serotonin levels in the neonatally injected handled animals following repeated forced swimming. The serotonergic system appears to be sensitive to both the organizational actions of testosterone and the effects of handling, since handled androgenized females had higher serotonin levels and decreased turnover following repeated forced swimming stress, compared to those injected neonatally with vehicle. Handling resulted in increased hypothalamic and striatal serotonin levels in both males and females following repeated forced swimming. Our results reveal that handling has gender-dependent effects on adult hypothalamic-pituitary-adrenal axis and brain monoaminergic system reactivity to stress and that these effects can be attributed to both the organizational and activational effects of gonadal hormones.

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Early life handling decreases serotonin turnover in the nucleus accumbens and affects feeding behavior of adult rats

Portella

Silveira

Diehl

et al. 2010

Developmental Psychobiology

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In our previous studies, we reported that neonatally handled rats have an increased ingestion of sweet food but are resistant to the damaging effects of a chronic exposure to a highly palatable diet. Accumbal serotonin (5-HT) is important for feeding behavior and plays a role in the vulnerability to diet-induced obesity. Therefore, our hypotheses were (1) 5-HT turnover in the nucleus accumbens is altered in neonatally handled animals and plays a role in their differential feeding behavior and (2) if this is so, a chronic pharmacological treatment affecting 5-HT reuptake (chronic imipramine) would be able to revert the behavioral findings. Litters were divided into nonhandled and handled (10 min/day, Days 1-10 after birth). In Experiment 1, we demonstrated that a decreased 5-HT metabolism in the nucleus accumbens was observed in adult handled animals. In Experiment 2, the two previous groups were subdivided and assigned to receive imipramine diluted in water or water alone. After 30 days of treatment, we evaluated their weight gain and feeding behavior. Handled rats weighed less than nonhandled rats, and all imipramine-treated rats showed a reduction in weight gain after 60 days of treatment. Imipramine reverted the increased sweet food consumption seen in neonatally handled rats. We conclude that serotonin is involved in the altered feeding behavior of neonatally handled rats, and this protocol is an important tool for studying the mechanisms by which early life events have a long-term impact on feeding preferences.

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Effects of neonatal handling on basal and stress-induced monoamine levels in the male and female rat brain

Cited by 77 publications

References 59 publications

Sculpting Cerebral Cortex with Serotonin in Rodent and Primate

Sculpting Cerebral Cortex with Serotonin in Rodent and Primate

Neonatal Handling and Gender Modulate Brain Monoamines and Plasma Corticosterone Levels following Repeated Stressors in Adulthood

Early life handling decreases serotonin turnover in the nucleus accumbens and affects feeding behavior of adult rats

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