Effects of neodymium–yttrium–aluminum garnet (Nd:YAG) pulsed high-intensity laser therapy on full thickness wound healing in an experimental animal model

Abstract

Nd:YAG HILT stimulated fibroblast proliferation and increased extracellular matrix production. We expect that this therapy could accelerate the wound-healing process.

Clinical effects of high-intensity laser therapy on patients with chronic refractory wounds: a randomised controlled trial

“…28 The physiological effects of laser therapy include alterations in cell membrane permeability, with changes in intracellular calcium levels; increased cellular metabolism; altered DNA and RNA synthesis; fibroblast proliferation; activation of T lymphocytes, macrophages and mast cells; increased synthesis of endorphins and decreased synthesis of bradykinin. 29 Hong et al 25 reported the biostimulatory effects of HILT on wound-healing process, demonstrating that HILT could promote fibroblast proliferation and result in significant increases in collagen synthesis, granulation tissue formation and extracellular matrix production. Furthermore, the anti-inflammatory effect of HILT can be achieved by the modulation of the inflammatory response, exudation, alteration and proliferation; stimulation of the readaptive reactions of the organism and inhibition of cyclooxygenases and lipoxygenases with modulation of prostaglandin and prostacyclin synthesis.…”

“… 24 Using a laser with a wavelength of 1064 nm provides the best absorption and penetration into tissue as its absorption by tissue chromophores, such as haemoglobin, melanin and water, is lower,; thereby enhancing the wound-healing process. 25 The 1064 nm laser wavelength has other beneficial properties. It provides photobiomodulation by inducing increases in oxygen consumption, endogenous ATP synthesis and fission rate rhythm.…”

Q-switched Nd-YAG laser alone and in combination with innovative hyaluronic acid gels improve keratinocytes wound healing in vitro

“…It is well worth noting that the main mechanism by which the Q-switched Nd:YAG laser exerts its action on tissues is the photo-mechanical effect, while that exert by the long-pulsed Nd:YAG laser is the photo-thermal effect [ 7 , 8 ]. The neodymium-doped yttrium aluminum garnet (Nd:YAG laser) is a laser that issues various wavelengths and can operate in continuous, long-pulsed, Q-switched, or potassium titanyl phosphate (KTP) modes.…”

“…Q-switched Nd:YAG laser 1064 nm is able to penetrate the tissue more deeply and reduce tissue damage. Thanks to its shorter pulse width, Q-switched Nd:YAG laser delivers, selectively in the upper dermis, higher doses of energy and stimulates cellular metabolism, with lower temperature and thus damages for epidermidis [ 7 , 8 ]. A number of laser devices and light sources, emitting at various wavelengths through non-ablative mechanisms, have been described that effectively improve the appearance of aged skin.…”

“…Narrow bands of visible light (400–800 nm LED) on photo-rejuvenation were specifically investigated with interesting clinical results [ 9 ]. Previous studies have been showed that the photo-mechanical effect would promote more effectively the synthesis of collagen type III, while the photo-thermal effect would elicit more sharply the formation of collagen type I [ 8 ]. Being collagen type III, the predominant isotype of fetal and youth skin gradually replaced by collagen type I during the aging process, it may play a pivotal role in skin remodeling [ 10 ].…”