Effects of Nelumbo nucifera Leaf Extract on Obesity

Liu, Enuo; Tsuboi, Hiroshi; Ikegami, Shuji; Kamiyama, Tomonori; Asami, Yukio; Ye, Luyi; Oda, Munehiro; Ji, Zai-Si

doi:10.1007/s11130-020-00852-w

Cited by 8 publications

(5 citation statements)

References 31 publications

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“…Nelumbo nucifera contains quercetin-3-O-ß-glucuronide (Q3GA) and quercetin; experiments conducted in vitro confirmed that quercetin and Q3GA affect lipid metabolism by promoting triglyceride degradation through inhibition of the cAMP pathway which in turn blocks the TNF-α pathway [ 90 ].…”

Section: Resultsmentioning

confidence: 99%

Nutraceuticals and the Network of Obesity Modulators

Ammendola¹,

d’Abusco

2022

Nutrients

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Obesity is considered an increasingly widespread disease in the world population, regardless of age and gender. Genetic but also lifestyle-dependent causes have been identified. Nutrition and physical exercise play an important role, especially in non-genetic obesity. In a three-compartment model, the body is divided into fat mass, fat-free mass and water, and obesity can be considered a condition in which the percentage of total fat mass is in excess. People with a high BMI index or overweight use self-medications, such as food supplements or teas, with the aim to prevent or treat their problem. Unfortunately, there are several obesity modulators that act both on the pathways that promote adipogenesis and those that inhibit lipolysis. Moreover, these pathways involve different tissues and organs, so it is very difficult to identify anti-obesity substances. A network of factors and cells contributes to the accumulation of fat in completely different body districts. The identification of natural anti-obesity agents should consider this network, which we would like to call “obesosome”. The nutrigenomic, nutrigenetic and epigenetic contribute to making the identification of active compounds very difficult. This narrative review aims to highlight nutraceuticals that, in vitro or in vivo, showed an anti-obesity activity or were found to be useful in the control of dysfunctions which are secondary to obesity. The results suggest that it is not possible to use a single compound to treat obesity, but that the studies have to be addressed towards the identification of mixtures of nutraceuticals.

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Section: Resultsmentioning

confidence: 99%

Nutraceuticals and the Network of Obesity Modulators

Ammendola¹,

d’Abusco

2022

Nutrients

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“…In addition to compounds mentioned above, Nelumbo nucifera leaf (NL) extract, reportedly possessing benefits on health, contains polyphenols including gallic acid, catechin, caffeic acid, ρ-coumaric acid, ferulic acid, peltatoside, rutin, isoquercitrin, miquelianin, astragalin, nuciferine, quercitrin, naringenin, and hesperetin . Because of these polyphenols in the NL having various bioactivities, the NL modulates fat and sugar absorption to regulate their metabolism . Harish et al demonstrated that the NL attenuated isoproterenol-induced myocardial infarction in Wistar rats, thereby exhibiting cardioprotective effects .…”

Section: Introductionmentioning

confidence: 99%

“…14 Because of these polyphenols in the NL having various bioactivities, the NL modulates fat and sugar absorption to regulate their metabolism. 15 Harish et al demonstrated that the NL attenuated isoproterenol-induced myocardial infarction in Wistar rats, thereby exhibiting cardioprotective effects. 16 Our studies have revealed that the NL prevents atherosclerosis by inhibiting the migration and proliferation of vascular smooth muscle cells 17 and melanogenesis.…”

Section: Introductionmentioning

confidence: 99%

Quercetin-3-O-β-d-glucuronide in the Nuciferine Leaf Polyphenol Extract Promotes Neurogenesis Involving the Upregulation of the Tropomyosin Receptor Kinase (Trk) Receptor and AKT/Phosphoinositide 3-Kinase Signaling Pathway

Lee,

Chen,

et al. 2023

J. Agric. Food Chem.

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Neurogenesis is crucial during the human lifespan for the maintenance of synaptic plasticity and normal function. The impairment of hippocampal neurogenesis in adults may lead to neurodegenerative disease, such as Alzheimer’s disease. Miquelianin (quercetin-3-O-β-d-glucuronide, Q3GA) is a constituent of the nuciferine leaf polyphenol extract (NLPE), and it has protective effects against neurodegeneration. In this study, we examined the effect of the NLPE on neurogenesis and the mechanisms underlying Q3GA on neurogenesis. We fed 24-week-old male C57BL/6 mice with 0.1 or 0.25% NLPE for 2 weeks. NLPE treatment increased small spindle-shaped stem cell numbers in the subgranular zone and the number of doublecortin (DCX)- and neuron-specific nuclear protein (NeuN)-expressing neurons. HT22, a hippocampal cell line, treated with Q3GA revealed significant neurite growth and upregulated TrkR and PI3K/Akt levels. The evidence from a model of retinoic acid-induced SH-SY5Y cell differentiation showed that Q3GA or NLPE increases neurite growth significantly. Taken together, the NLPE containing Q3GA to promote neurogenesis involving the upregulation of TrkR and the PI3K/Akt signaling pathway might be potentiated as an alternative strategy for the treatment of neurodegeneration.

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“…It has been a long time since the leaves, roots, seeds, and other parts have been used as food. As a traditional herbal medicine, the lotus, particularly the leaves, extract, fractions, and other constituents, has been proven to have diverse applications in both biology and pharmacology, i.e., antioxidant, antibacterial, antiviral, antifungal, immunomodulation, anti-inflammatory, anti-diarrheal, anti-thrombotic, anti-diabetic, cholesterol-lowering, anti-obesity, and anti-cancer properties [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ], due to multiple bioactive compounds, including flavonoids, polyphenols, steroids, phenolic acids, polysaccharides, alkaloids, terpenoids, fatty acids, and glycosides [ 14 , 15 , 18 , 22 , 23 ]. In Asia, lotus leaves are usually applied as a functional food [ 24 ] and as a supplement with which to treat obesity.…”

Section: Introductionmentioning

confidence: 99%

“…In Asia, lotus leaves are usually applied as a functional food [ 24 ] and as a supplement with which to treat obesity. During the last several decades, many researchers have explored the probiotic characteristics of lotus leaves in regards to obesity [ 16 , 17 , 21 , 22 , 25 , 26 ], for these, some mechanisms of action are clear. To provide a specific example, Wang et al reported that nuciferine (NUC) could inhibit the development of obesity, which might be accounted for by the fact that it can regulate the composition and potential capacity of intestinal microbiota, improve the function of the intestinal barrier, and prevent chronic low-grade inflammation [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Lotus (Nelumbo nucifera Gaertn.) Leaf-Fermentation Supernatant Inhibits Adipogenesis in 3T3-L1 Preadipocytes and Suppresses Obesity in High-Fat Diet-Induced Obese Rats

Yue

Qiu

et al. 2022

Nutrients

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The lotus (Nelumbo nucifera Gaertn.) leaf is a typical homologous ingredient of medicine and food with lipid-lowering and weight-loss effects. In the present study, lotus leaves were fermented by two probiotics, Enterococcus faecium WEFA23 and Enterococcus hirae WEHI01, and the anti-adipogenic effect of Enterococcus fermented lotus leaf supernatant (FLLS) was evaluated in 3T3-L1 preadipocytes with the aim of exploring whether its anti-obesity ability will be enhanced after fermentation with Enterococcus and to dig out the potential corresponding mechanism. The FLLS fermented by E. hirae WEHI01 (FLLS-WEHI01) was selected and further investigated for its ability to inhibit obesity in vivo in high-fat diet (HFD)-induced obese rats (male, 110 ± 5 g, 4 weeks old) due to its superior inhibitory effect on adipogenesis and lipid accumulation (inhibition rate of up to 56.17%) in 3T3-L1 cells (p = 0.008 for WEHI01-L, p < 0.001 for WEHI01-H). We found that the oral administration of both the low and high doses of FLLS-WEHI01 could achieve some effects, namely decreasing body weight (p < 0.001), epididymal fat mass, adipocyte cell size, LDL-C levels (p = 0.89, 0.02, respectively), liver TC levels (p < 0.001, p = 0.01, respectively), and TG levels (p = 0.2137, p = 0.0464, respectively), fasting blood glucose (p = 0.1585, p = 0.0009), and improved insulin resistance (p = 0.33, 0.01, respectively) in rats of the model group. Moreover, the administration of both high and low doses of FLLS-WEHI01 decreased the transcription levels of adipogenic transcription factors and corresponding genes such as Pparγ (p < 0.001), Cebpα (p < 0.001), Acc (p < 0.001), and Fas (p < 0.001) by at least three times. These results indicate that FLLS-WEHI01 can potentially be developed as an healthy, anti-obesity foodstuff.

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Effects of Nelumbo nucifera Leaf Extract on Obesity

Cited by 8 publications

References 31 publications

Nutraceuticals and the Network of Obesity Modulators

Nutraceuticals and the Network of Obesity Modulators

Quercetin-3-O-β-d-glucuronide in the Nuciferine Leaf Polyphenol Extract Promotes Neurogenesis Involving the Upregulation of the Tropomyosin Receptor Kinase (Trk) Receptor and AKT/Phosphoinositide 3-Kinase Signaling Pathway

Lotus (Nelumbo nucifera Gaertn.) Leaf-Fermentation Supernatant Inhibits Adipogenesis in 3T3-L1 Preadipocytes and Suppresses Obesity in High-Fat Diet-Induced Obese Rats

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