Effects of negatively charged aerosol on blood and cerebrospinal fluid parameters in rats

Wehner, Alfred P.; Ragan, H.A.; Jaffe, Richard A.; Weigel, R.J.; Lundstrom, D. L.

doi:10.1007/bf02184241

Cited by 2 publications

(2 citation statements)

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“…Data from 39 tests extracted from three of these studies are summarized in Additional file 2 : Figure S8. Wehner et al [ 123 ] exposed rats in a single group of 10 animals to negative air ion aerosols for 90–140 min and then analyzed for 21 blood components typically included in general blood work-ups for humans and for pH and Ca ++ concentration in cerebrospinal fluid. One of these measures, mean corpuscular hemoglobin concentration, differed modestly from the control group at p < 0.01 and the authors considered this finding as likely due to chance.…”

Section: Resultsmentioning

confidence: 99%

“…Bailey and Charry [ 57 , 78 , 82 ] used a specially-designed exposure system evaluated by the US National Bureau of Standards to prevent such confounders [ 130 ]. For a few other ion generation systems there would appear to be little need for control measures on gaseous by-products [ 108 , 109 , 123 ]. Overall, the studies that addressed the greatest number of confounding variables related to the use of a corona discharge system for the generation of air ions were Olivereau and Lambert [ 48 ], Bailey and Charry [ 57 , 78 , 82 ], and Creim et al [ 59 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

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Exposure of laboratory animals to small air ions: a systematic review of biological and behavioral studies

2018

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BackgroundAir ions are molecules of air that have become ionized—that is, they have either lost or gained an electrical charge. Past speculation has suggested that exposure to positive air ions may be harmful to one’s health, while exposure to negative air ions may be associated with beneficial health effects. Air ions arise from natural sources as well as direct-current transmission lines and commercial ionizers. Several recent clinical studies have suggested therapeutic effects of air ions on various types of depression at exposure levels 10- to 1000-fold higher than most previous human studies. The aim of this study was to assess the evidence from studies of laboratory animals for beneficial or adverse effects of air ions on health.MethodsSixty-two studies (1935–2015) in nine topics areas were evaluated for quality and potential systematic bias by ARRIVE guidelines. Standardized mean differences or proportional differences between exposed and control groups were computed for 44 studies to quantitatively assess the strength of the evidence for exposure-related effects.ResultsMany of the studies were conducted before 1990 and exhibited various reporting and methodological deficiencies, including small sample size, failure to control for the influence of potential confounding variables, lack of randomized assignment to treatment groups and blinded analyses, and statistical errors relating to treating group-exposed animals as individuals. The highest quality studies consistently reported no effects of exposure on any of the endpoints examined. There were no evident dose–response relationships within or across studies.ConclusionsExperimental studies of laboratory animals exposed to positive and negative air ions for minutes to years over a five-log unit range of intensities did not suggest any consistent or reliable effects on measures of behavior, learning and memory, neurotransmitters, tracheal function, respiratory infection, cardiovascular function, reproduction and growth, carcinogenesis, or other health endpoints. These data do not provide evidence of adverse or beneficial effects of air ion exposure on health, and did not suggest any biological mechanism of interaction, except perhaps for mechanosensory stimulation of body surfaces by static electric fields at high air ion concentrations.Electronic supplementary materialThe online version of this article (10.1186/s12938-018-0499-z) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exposure of laboratory animals to small air ions: a systematic review of biological and behavioral studies

2018

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Negative Air Ions in Neuropsychiatric Disorders

Vecchia

Mucci

Pozza

et al. 2021

CMC

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Background: Air ions (AIs) are clusters of ionized particles present in the atmosphere and carrying an electrical charge of negative or positive polarity. Past speculations suggested that exposure to positive air ions may be harmful, while exposure to negative air ions (NAIs) may be associated with beneficial health effects. Increasing attention has been directed towards investigating the potential effect of NAIs on human brain activities since initial observations of their beneficial effects on some cognitive processes and mood. Aims: Given the paucity and scattered literature, the aim of our paper is at reviewing available studies on potential positive effects of NAIs exposure on cognitive performances and depression. Discussion: The review of the literature seems to confirm effects of NAIs on several brain functions. Indeed, a significant association between NAIs exposure and both wellbeing and high cognitive performances has been described. However, the exposure to high concentrations of NAIs could be related to improvement of depressive symptoms. Conclusion: A growing evidence of data, although not yet conclusive, would suggest that NAIs might improve cognitive processes. These findings require specific and urgent controlled trials adopting systems based on AIs release to possible prevent and treat cognitive dysfunctions present in a broad range of neuropsychiatric conditions.

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Effects of negatively charged aerosol on blood and cerebrospinal fluid parameters in rats

Cited by 2 publications

References 8 publications

Exposure of laboratory animals to small air ions: a systematic review of biological and behavioral studies

Exposure of laboratory animals to small air ions: a systematic review of biological and behavioral studies

Negative Air Ions in Neuropsychiatric Disorders

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