Effects of negative-pressure wound therapy combinedwith microplasma on treating wounds of ulcer and the expression of heat shock protein 90

Abstract

The effects of negative pressure wound therapy (NPWT) combined with microplasma on treating wounds of ulcer, and blood perfusion of wound-healing of interface, angiogenesis and the expressions of heat shock protein 90 (HSP90) were explored. We selected continuously 64 patients with wounds of ulcer. The patients were divided into the conventional treatment group (just medical foam dressing and 1% silver sulfadiazine cream for dressing changes) (n=20 cases), the NPWT group (n=22 cases) and the combination group (NPWT combined with microplasma) (n=22 cases), and compared the effects. It was found that in the 7 and 14 day combination group, maturity of granulation tissues and growth degree of epithelium were significantly higher than those in other two groups, and the areas of ulcer reduced significantly, the healing rate increased significantly (P<0.05). In the 7 and 14 day combination group, blood perfusion of wounds and density of new vessels were significantly higher than the other two groups (P<0.05). In the 7 and 14 day combination group, the expression of HSP90 was significantly higher than the other two groups (P<0.05). In conclusion, NPWT combined with microplasma can improve the healing of woulds of ulcers, and it is related to the upregulated expression of HSP90.

Virtual Reality-Based Analysis of Pressure Ulcer Care Information Related to Medical Equipment for the Prevention of Pressure Ulcer Skin Foam Dressings in the Elderly

“…In the case of improper nursing measures, it is easy to induce pressure sores. The prevalence of pressure ulcers during operation is related to the surgical position, and the surgical position determines the pressure position of the patient [ 17 , 18 ]. Patients undergoing thoracoabdominal combined laparoscopic radical esophageal cancer surgery are first imaged in the left position and then in the supine position.…”

Skin perfusion pressure as a predictor of ischemic wound healing potential (Review)

“…Patients with ischemic ulcers often suffer from at-rest pain and may develop gangrene (1). Previous studies have demonstrated that negative pressure wound therapy may accelerate wound healing by promoting blood perfusion (2,3). However, revascularization to restore perfusion is critical for the treatment and prevention of ischemic ulcers in different clinical guidelines (4,5).…”

Negative pressure wound therapy versus healing by secondary intention in pressure ulcers

“…At weeks 1, 2 and 3, depth was significantly (p<0.05) higher in NPWT group, whereas at week 9 a significant reduction (p=0.01) was observed and NPWT plus microplasma using the following outcome measures -the maturity of granulations, growth degree of epithelium, blood perfusion, density of new vessels, wound area and total healing rate. 37 The combination of NPWT with microplasma yielded the best results followed by NPWT alone and conventional treatment. The quality of life (QoL) was evaluated in only one trial.…”