Effects of negative-pressure therapy with and without ropivacaine instillation in the early evolution of severe peritonitis in pigs

Pigs represent a potentially attractive model for medical research. Similar body size and physiological patterns of kidney injury that more closely mimic those described in humans make larger animals attractive for experimentation. Using larger animals, including pigs, to investigate the pathogenesis of acute kidney injury (AKI) also serves as an experimental bridge, narrowing the gap between clinical disease and preclinical discoveries. This article compares the advantages and disadvantages of large versus small AKI animal models and provides a comprehensive overview of the development and application of porcine models of AKI induced by clinically relevant insults, including ischemia-reperfusion, sepsis, and nephrotoxin exposure. The primary focus of this review is to evaluate the use of pigs for AKI studies by current investigators, including areas where more information is needed.

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Porcine models of acute kidney injury

Huang

Bayliss

Zhuang

2021

American Journal of Physiology-Renal Physiology

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Effects of negative-pressure therapy with and without ropivacaine instillation in the early evolution of severe peritonitis in pigs

Cited by 1 publication

References 28 publications

Porcine models of acute kidney injury

Porcine models of acute kidney injury

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