Effects of natural polymers for enhanced silica-based mesoporous drug carrier

Aramideh, Alireza; Ashjari, Mohsen; Niazi, Zahra

doi:10.1016/j.jddst.2023.104189

Cited by 7 publications

(4 citation statements)

References 44 publications

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“…However, a toxic response was obtained by exposure the SiGe/BSA-FA@5FU carrier to both cancer and normal cells, which is due to the presence of 5FU. In addition, the drug-loaded carrier showed less cell viability against OVCAR-3 cells than HDF cells after 24 and 48 h, at about 69 and 51%, respectively, which con rmed more cytotoxic effect of SiGe/BSA-FA@5FU against cancerous cells compared to the normal cells [27]. In addition, increasing exposure time from 24 to 48 h, was led to less cell viability from 69% down to 51% in cancerous cells, and from 81-73% in normal cells, respectively.…”

Section: Toxicity Studiesmentioning

confidence: 90%

“…Furthermore, the appeared hysteresis loops in these isotherms shows the occurrence of capillary condensation in mesoporous structure of nanocarriers. Here, the type of hysteresis loops refers to type H-2, which indicates interconnected pore networks along with a partially agglomeration in structure [27,32].In addition, the pore size distribution in Fig. 4.b shows a narrow and uniform distribution in the range of 2-40 nm.…”

Section: Characterization Of Prepared Carriersmentioning

confidence: 97%

“…2. The broad band around 3400 cm − 1 in all spectra is due to stretching vibrations of the O-H or N-H bonds [27]. In the FTIR spectra of the SiGe, and SiGe/BSA-FA, the observed bands around 1100, 470 and 800 cm − 1 are related to Si − O−Si stretching, Si − O stretching, and Si − O bending mode of silica network, respectively [28].…”

Section: Characterization Of Prepared Carriersmentioning

confidence: 99%

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Folate-targeted albumin modified silica-gelatin hybrid nanocarrier. Synthesis and release characterization

Niazi,

Ashjari

2024

Preprint

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A novel hybrid of BSA-folate modified silica-gelatin nanocarrier with surface area of about 422 m2/g was designed in the current study and loaded by fluorouracil with 70 % entrapment efficiency. The nanocarrier was evaluated in terms of pH-sensitive release behavior in simulated acidic condition of cancer tissue (pH=5.), and the normal physiological condition of the body (pH=7.4) for 96 h. In vitro drug release from nanocarriers indicated a partial burst release in the early times (34 and 21 % after 12 h in acidic and neutral media), which was followed by a sustained and gradual release profile until 96 h. In addition, an enhanced drug release was observed at acidic pH (65 % after 96 h) compared to natural medium (42 % after 96 h), confirming the pH-responsive behavior of the developed nanocarrier. The MTT assay showed low toxicity of drug-free carrier against normal HDF fibroblast, and the OVCAR-3 ovarian cancer cells. These outcomes support the proper function of designed hybrid nanocarrier in targeted drug delivery.

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Section: Toxicity Studiesmentioning

confidence: 90%

Section: Characterization Of Prepared Carriersmentioning

confidence: 97%

Section: Characterization Of Prepared Carriersmentioning

confidence: 99%

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Folate-targeted albumin modified silica-gelatin hybrid nanocarrier. Synthesis and release characterization

Niazi,

Ashjari

2024

Preprint

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“…Nanocarriers can significantly promote the delivery of the drugs and improve their bioavailability, especially for drugs with poor water solubility. Some nanoparticles, such as polymers or mesoporous silica, have been developed as anticancer drug carriers [3][4][5][6]. However, the defects of their degradation resistance and low loading capacity limit their development.…”

Section: Introductionmentioning

confidence: 99%

One-Pot Preparation of HCPT@IRMOF-3 Nanoparticles for pH-Responsive Anticancer Drug Delivery

Cheng

2023

Molecules

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Metal–organic frameworks (MOFs) are considered to be promising materials for drug delivery. In this work, a Zinc-based MOF nanocomposite IRMOF-3 was introduced as a drug carrier for 10-hydroxycamptothecine (HCPT). Without an extra drug-loading process, a nanoscale drug delivery material HCPT@IRMOF-3 was prepared via one-pot synthesis. The composition and structure of the material were investigated, and the drug release character was measured. Compared with preparing IRMOF-3 first and loading the drug, the one-pot-prepared HCPT@IRMOF-3 exhibited a higher drug-loading capacity. The material presented pH-responsive release. The HCPT release rate at pH 5.0 was significantly higher than that at pH 7.4. The cytotoxicity experiments showed that IRMOF-3 was non-toxic, and HCPT@IRMOF-3 exhibited notable cytotoxicity to Hela and SH-SY5Y cells. One-pot synthesis is a simple and rapid method for the preparation of an MOF drug delivery system, and IRMOF-3 can be potentially used in pH-responsive drug delivery systems.

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Folate-targeted albumin modified silica-gelatin hybrid nanocarrier involving synthesis and release characterization

Niazi,

Ashjari

2024

J Porous Mater

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Effects of natural polymers for enhanced silica-based mesoporous drug carrier

Cited by 7 publications

References 44 publications

Folate-targeted albumin modified silica-gelatin hybrid nanocarrier. Synthesis and release characterization

Folate-targeted albumin modified silica-gelatin hybrid nanocarrier. Synthesis and release characterization

One-Pot Preparation of HCPT@IRMOF-3 Nanoparticles for pH-Responsive Anticancer Drug Delivery

Folate-targeted albumin modified silica-gelatin hybrid nanocarrier involving synthesis and release characterization

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