Effects of Natural Flavonoid Isoorientin on Growth Performance and Gut Microbiota of Mice

Abstract

Isoorientin (ISO) is a natural flavonoid, which is a 6- C-glucoside of luteolin, and has been demonstrated to possess multiple biological properties. In this study, the effects of ISO on the growth performance and gut microbiota of BALB/c mice were investigated. The results showed that ISO could promote food intake and body weight gain, increase the digestibility of crude proteins and utilization of the gross energy, and strengthen antioxidant capacity of mice. We also demonstrated it has no side effects on hepatic and renal functions. Moreover, ISO inhibited the growth of most bacteria in gut microbiota, especially the pathogenic genera of Alistipes, Helicobacter, and Oscillibacter, which could lead to inflammation. Metabolisms of epithelial cell signaling in Helicobacter pylori infection, lipopolysaccharide (LPS) biosynthesis, and LPS biosynthesis proteins in gut microbiota of the control group were more abundant than those in the ISO group, while lipid metabolism and vitamin B metabolism were enriched in the ISO group. We found the changes in enrichments of metabolic pathways of the gut microbiota along with the ISO application were positively correlated with the antioxidation, anti-inflammation, and antibiosis. This work provided a fundamental basis for the future development of ISO-functional foods used for resistance to oxidation, inflammation, and pathogens.

Camellia sinensis and Litsea coreana Ameliorate Intestinal Inflammation and Modulate Gut Microbiota in Dextran Sulfate Sodium‐Induced Colitis Mice

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A Novel Antidiabetic Monomers Combination Alleviates Insulin Resistance Through Bacteria-Cometabolism-Inflammation Responses

“…In addition, the abundance of certain bacteria was significantly reduced in the AMC group compared to that of the HFD group. These bacteria, including Bacteroides (Pedersen et al, 2016;Schulfer et al, 2018), Odoribacter (Schulfer et al, 2018), Parabacteroides (Kang et al, 2018), Prevotella 9 (Pedersen et al, 2016), Alistipes (Kang et al, 2018;Yuan et al, 2018), Parasutterella (Chen et al, 2018), Klebsiella (Atarashi et al, 2017), and Haemophilus (Fernández-Calvet et al, 2018) were shown to positively correlate with the inflammatory state of the body, driving insulin resistance. Further, co-metabolite analyses identified significant AMC-induced metabolite changes in the feces that could serve as potential biomarkers in improving or inducing insulin resistance, including HPLA, palmitoleic acid, dodecanoic acid, linoleic acid, and erucic acid.…”

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