Effects of Nasal Positive Airway Pressure Treatment on Oxidative Stress in Patients With Sleep Apnea-Hypopnea Syndrome

Hernández, Coromoto León; Abreu, Juan; Abreu, Pedro; Colino, Rocío Menéndez; Jiménez, Alejandro

doi:10.1016/s1579-2129(06)60130-4

Cited by 19 publications

(16 citation statements)

References 24 publications

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“…We found a significant reduction in total score after approximately 1 month of treatment. The change in score was observed by Chiner et al [18] and by other studies using the original version of the scale [33][34][35][36]. In the development of the modified version of the ESS-PV for non-driving people, there were four alternative items, which would replace the item 8 of the ESS-PV.…”

Section: Discussionmentioning

confidence: 89%

Validation and modification of the Epworth Sleepiness Scale in Peruvian population

et al. 2011

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Section: Discussionmentioning

confidence: 89%

Validation and modification of the Epworth Sleepiness Scale in Peruvian population

et al. 2011

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“…With the intervention of nasal continuous positive airway pressure (CPAP) for 3 months, they found a significant decrease of MDA and consequently of the degree of endothelial dysfunction that predispose to vascular morbidity [29].…”

Section: Hypoxia Oxidative Stress and Inflammatory Responsementioning

confidence: 99%

The role inflammatory response genes in obstructive sleep apnea syndrome: a review

et al. 2015

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“…ROS and RNS exerted their cellular harmful effects, which can be counteracted by a variety of specific antioxidants [21]. The plasma concentration of an oxidative marker malondialdehyde (MDA) was found to be higher in patients with OSA than in control subjects [22], suggesting a possible role of oxidative stress in the pathogenesis of OSA. It is also known that inflammation and oxidative stress are reciprocal causes and outcomes [23], and oxidative stress is associated with vascular inflammation.…”

Section: Introductionmentioning

confidence: 99%

Deletion of Metallothionein Exacerbates Intermittent Hypoxia-Induced Oxidative and Inflammatory Injury in Aorta

Zhou

Wang

Tan

et al. 2014

Oxidative Medicine and Cellular Longevity

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The present study was to explore the effect of metallothionein (MT) on intermittent hypoxia (IH) induced aortic pathogenic changes. Markers of oxidative damages, inflammation, and vascular remodeling were observed by immunohistochemical staining after 3 days and 1, 3, and 8 weeks after IH exposures. Endogenous MT was induced after 3 days of IH but was significantly decreased after 8 weeks of IH. Compared with the wild-type mice, MT knock-out mice exhibited earlier and more severe pathogenic changes of oxidative damages, inflammatory responses, and cellular apoptosis, as indicated by the significant accumulation of collagen, increased levels of connective tissue growth factor, transforming growth factor β1, tumor necrosis factor-alpha, vascular cell adhesion molecule 1,3-nitrotyrosine, and 4-hydroxy-2-nonenal in the aorta. These findings suggested that chronic IH may lead to aortic damages characterized by oxidative stress and inflammation, and MT may play a pivotal role in the above pathogenesis process.

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Effects of Nasal Positive Airway Pressure Treatment on Oxidative Stress in Patients With Sleep Apnea-Hypopnea Syndrome

Cited by 19 publications

References 24 publications

Validation and modification of the Epworth Sleepiness Scale in Peruvian population

Validation and modification of the Epworth Sleepiness Scale in Peruvian population

The role inflammatory response genes in obstructive sleep apnea syndrome: a review

Deletion of Metallothionein Exacerbates Intermittent Hypoxia-Induced Oxidative and Inflammatory Injury in Aorta

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