Effects of napping on neuromuscular fatigue in myasthenia gravis

Kassardjian, Charles D.; Murray, Brian J.; Kokokyi, Seint; Jewell, Dana; Barnett, Carolina; Bril, Vera; Katzberg, Hans D.

doi:10.1002/mus.23941

Cited by 13 publications

(12 citation statements)

References 6 publications

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“…In contrast, well‐rested MG patients and controls (including the subgroup with daytime sleepiness) did not have objective fatigue. Thus, daytime sleepiness may be discussed as a predisposing factor to cognitive fatigability . However, daytime sleepiness is based on a self‐assessment and certainly overlaps with psychological factors.…”

Section: Discussionmentioning

confidence: 99%

Cognitive fatigue in patients with myasthenia gravis

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Cognitive fatigue in patients with myasthenia gravis

et al. 2017

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“…Double-filtration plasmapheresis results in minimal improvement of respiratory parameters. Kassardjian et al 2012 27 ) Prospective Quantitative Myasthenia Gravis Score improves only after naps longer than 5 min. Daytime sleep minimizes neuromuscular fatigue in MG patients, especially if they sleep for more than 5 min.…”

Section: Resultsmentioning

confidence: 99%

Sleep disorders in patients with myasthenia gravis: a systematic review

et al. 2015

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[Purpose] This systematic review evaluated the presence of sleep-disordered breathing in patients with myasthenia gravis and clarified the role of physiotherapy. [Subjects and Methods] We followed the PRISMA declaration criteria. The evaluation was performed in accordance with the STROBE statement for observational and cross-sectional studies and the CONSORT checklist for clinical trials. Searches were followed by hand on MEDLINE, EMBASE, SciELO, PubMed Central, and the Cochrane Central Register of Controlled Trials. [Results] Our searches yielded a total of 36 studies published between 1970 and 2014. The number of patients involved ranged from 9–490. Of the 36 studies, 19 articles were excluded because they did not meet the inclusion criteria. Therefore, 17 observational, cross-sectional, or clinical studies assessing the quality of sleep and prevalence of sleep disorders in patients with myasthenia gravis were eligible for our review. [Conclusion] Some studies of patients with MG show that patients with MG are associated with poor sleep quality, excessive daytime sleepiness, presence of restless syndrome, and a higher incidence of SDB, while other studies do not report such associations. Therefore, given the current inconclusive evidence and limited literature, further study of sleep disturbances in patients with MG is needed.

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“…In clinical settings, insufficient sleep is well‐known among clinicians to often result in worsened MG symptoms the next day. In fact, supplemental sleep reportedly improves neuromuscular fatigue in MG . The present patient possibly had fatigue arising from OSA disturbing restorative sleep.…”

Section: Discussionmentioning

confidence: 99%

Improvement in generalized myasthenia gravis after continuous positive airway pressure therapy for obstructive sleep apnea: A case report

Komatsu

Onda

Iguchi

et al. 2015

Neurology & Clinical Neurosc

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We report a case of generalized myasthenia gravis with obstructive sleep apnea in which myasthenia gravis symptoms improved dramatically after initiation of continuous positive airway pressure therapy. A 42-year-old man was admitted with generalized myasthenia gravis. He was found to snore loudly during sleep and was diagnosed with obstructive sleep apnea by polysomnography. Continuous positive airway pressure therapy contributed to immediate improvements in not only the apnea-hypopnea index (70.6-20.9), but also the myasthenia gravis-specific activities of daily living scale (10-1) and quantitative myasthenia gravis scale (21-8). We suggest that when a myasthenia gravis patient is obese and suspected to have sleep problems, examinations to detect obstructive sleep apnea should be carried out. If obstructive sleep apnea is diagnosed, continuous positive airway pressure therapy might also improve the patient's myasthenia gravis.

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Effects of napping on neuromuscular fatigue in myasthenia gravis

Abstract: Daytime napping mitigates neuromuscular fatigue in patients with MG, especially if patients slept for more than 5 min.

Cited by 13 publications

References 6 publications

Cognitive fatigue in patients with myasthenia gravis

Cognitive fatigue in patients with myasthenia gravis

Sleep disorders in patients with myasthenia gravis: a systematic review

Improvement in generalized myasthenia gravis after continuous positive airway pressure therapy for obstructive sleep apnea: A case report

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