Effects of nanozeolite/starch thermoplastic hydrogels on wound healing

Abstract

Background:Wound healing is a complex biological process. Some injuries lead to chronic nonhealing ulcers, and healing process is a challenge to both the patient and the medical team. We still look forward an appropriate wound dressing.Materials and Methods:In this study, starch-based nanocomposite hydrogel scaffolds reinforced by zeolite nanoparticles (nZ) were prepared for wound dressing. In addition, a herbal drug (chamomile extract) was added into the matrix to accelerate healing process. To estimate the cytocompatibility of hydrogel dressings, fibroblast mouse cells (L929) were cultured on scaffolds. Then, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium-bromide assay test and interaction of cells and scaffolds were evaluated. For evaluating healing process, 48 male rats were randomly divided into four groups of four animals each (16 rats at each step). The ulcers of the first group were treated with the same size of pure hydrogels. The second group received a bandage with the same size of hydrogel/extract/4 wt% nZ (hydrogel NZE). The third group was treated with chamomile extract, and the fourth group was considered as control without taking any medicament. Finally, the dressings were applied on the chronic refractory ulcers of five patients.Results:After successful surface morphology and cytocompatibility tests, the animal study was carried out. There was a significant difference between starch/extract/4 wt% nZ and other groups on wound size decrement after day 7 (P < 0.05). At the clinical pilot study step, the refractory ulcers of all five patients were healed without any hypersensitivity reaction.Conclusion:Starch-based hydrogel/zeolite dressings may be safe and effective for chronic refractory ulcers.

Zeolite in tissue engineering: Opportunities and challenges

“…It's noteworthy that the refractory ulcers of five patients were healed without any hypersensitivity reaction at clinical pilot study. 95 …”

Microporous Frameworks as Promising Platforms for Antibacterial Strategies Against Oral Diseases

“…It is still difficult to achieve a favorable and satisfied effect on oral mucosal ulcer by current available treatments. Salehi et al (2017) prepared a starchbased nanocomposite hydrogel scaffold enhanced by zeolite nanoparticles. In addition, herbs (chamomile extract) were added into the matrix to promote wound healing (Salehi et al, 2017).…”

“…Salehi et al (2017) prepared a starchbased nanocomposite hydrogel scaffold enhanced by zeolite nanoparticles. In addition, herbs (chamomile extract) were added into the matrix to promote wound healing (Salehi et al, 2017). Animal experiments and clinical trials both showed that the combination of starch/zeolite nanocomposites and extracts could preferably improve wound healing, which washighly expected to be applied to the treatment of intractable ulcers in the mouth.…”

Evaluation of bioactivity and biodegradability of a biomimetic soft tissue scaffold for clinical use: An in vitro study

“…[ 18 , 25 - 27 ] Zeolite is an aluminosilicate with outstanding properties, thanks to its highly porous structure. [ 28 ] It has a range of applications in biomedical fields such as hemodialysis,[ 29 ] skin tissue engineering,[ 30 ] wound healing,[ 31 ] and bone and tooth tissue engineering. [ 26 , 32 ] It has been used as an antimicrobial agent,[ 33 , 34 ] in drug delivery systems,[ 35 ] and as an additive to dental materials.…”