Effects of Nanoparticles on Gastrointestinal Disorders and Therapy

Riasat, Rabia; Guangjun, Nie

doi:10.4172/2161-0495.1000313

Cited by 18 publications

(6 citation statements)

References 96 publications

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“…The role of nano-medicine in the gastrointestinal tract is regarded a promising therapeutic tool. Different types of nanoparticles have prospective uses in gastroenterology as they overcome the traditional treatment in several disorders 42 . AuNPs have begun to be actively used for diagnostic and therapeutic applications in several fields of nano-medicine 43 .…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of gold nanoparticles on DSS-induced ulcerative colitis in mice with reference to interleukin-17 expression

Abdelmegid

Abdo

Ahmed

et al. 2019

Sci Rep

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Ulcerative colitis (UC) is among the most challenging human diseases. Nanotechnology has incontestable promising outcomes in inflammatory bowel diseases. This study aimed to investigate the therapeutic effect of naked gold nanoparticles (AuNPs) on dextran sodium sulphate (DSS) induced ulcerative colitis in mice. We also examined the expression of interleukin-17 (IL-17) following AuNPs treatment. Mice were randomly divided into control, DSS and DSS+ AuNPs groups. Severity of colitis was assessed by disease activity index (DAI) measurement. At the end of the experiment, the final body weights were recorded. The colon was dissected and processed for histopathological examinations by light and electron microscopes. Colon homogenates were prepared for assay of tissue malondialdehyde (MDA) and real-time PCR analysis of IL-17A. Immunohistochemical localization of IL-17A was carried out. Scanning electron microscopy (SEM) and Energy Dispersive X-ray (EDX) detector were used to detect the presence of AuNPs in the colonic tissue of DSS+ AuNPs groups. Our results showed that AuNPs effectively targeted the colonic tissue, and reduced changes induced by DSS. The underlying mechanisms could be related to anti-oxidant effect (as evident by decreasing tissue MDA) and anti-inflammatory potential of AuNPs. Our study draws attention to as a novel therapeutic strategy for treating UC.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effect of gold nanoparticles on DSS-induced ulcerative colitis in mice with reference to interleukin-17 expression

Abdelmegid

Abdo

Ahmed

et al. 2019

Sci Rep

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“…Subsequently, there are two pathways for nanoparticles absorption, specifically the paracellular absorption, which occurs when the nanoparticles are small enough to pass through the spaces between the cells, and the transcellular uptake through enterocytes, either passively or by binding to specific receptors [22]. Hence, depending on the size, dispersibility, and the charge of the nanoparticle [16], they can diffuse through the gastrointestinal tract into the systemic circulation and translocate to other organs [23]. If the size is reduced, nanoparticles can cross the blood-brain barrier and accumulate in the brain [24].…”

Section: Routes Of Exposurementioning

confidence: 99%

Impact of Nanoparticles on Brain Health: An Up to Date Overview

Teleanu

Chircov

Grumezescu

et al. 2018

JCM

161

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Nanoparticles are zero-dimensional nanomaterials and, based on their nature, they can be categorized into organic, inorganic, and composites nanoparticles. Due to their unique physical and chemical properties, nanoparticles are extensively used in a variety of fields, including medicine, pharmaceutics, and food industry. Although they have the potential to improve the diagnosis and treatment of brain diseases, it is fundamentally important to develop standardized toxicological studies, which can prevent the induction of neurotoxic effects. The focus of this review is to emphasize both the beneficial and negative effects of nanoparticles on brain health.

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“…The mucous barrier, transit time, and unpredictable peristalsis will condition the transport of food, medicines, as well as the ways in which NPs may potentially interact with our alimentary tract and the microbiota present therein [39] (Fig. 3) [40]. Increased consumption of TiO 2 NPs can have a negative impact on the human microbiome in the process of direct food consumption and/or during its passage through the intestine.…”

Section: Causes and Consequences Of Intestinal Microbiota Alterations Due To Tio 2 Nps Exposurementioning

confidence: 99%

“…3 Microbiota population in different organs of the gastrointestinal (GI) tract. Based on Riasat et al[40]…”

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confidence: 99%

Factors Conditioning the Potential Effects TiO2 NPs Exposure on Human Microbiota: a Mini-Review

Baranowska‐Wójcik

2021

Biol Trace Elem Res

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The recent years have seen a significant interest in the applications of nanotechnology in various facets of our lives. Due to their increasingly widespread use, human exposure to nanoparticles (NPs) is fast becoming unavoidable. Among the wide group of nanoparticles currently employed in industry, titanium dioxide nanoparticles, TiO2 NPs, are particularly popular. Due to its white colour, TiO2 is widely used as a whitening food additive (E 171). Yet, there have been few studies aimed at determining its direct impact on bacteria, while the available data suggest that TiO2 NPs may influence microbiota causing problems such as inflammatory bowel disease, obesity, or immunological disorders. Indeed, there are increasing concerns that its presence may lead to intestinal barrier impairment, including dysbiosis of intestinal microbiota. This article aims to present an overview of studies conducted to date with regard to the impact of TiO2 NPs on human microbiota as well as factors that can affect the same. Such information is necessary if we are to conclusively determine the potential toxicity of inorganic nanoparticles.

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Effects of Nanoparticles on Gastrointestinal Disorders and Therapy

Cited by 18 publications

References 96 publications

Therapeutic effect of gold nanoparticles on DSS-induced ulcerative colitis in mice with reference to interleukin-17 expression

Therapeutic effect of gold nanoparticles on DSS-induced ulcerative colitis in mice with reference to interleukin-17 expression

Impact of Nanoparticles on Brain Health: An Up to Date Overview

Factors Conditioning the Potential Effects TiO2 NPs Exposure on Human Microbiota: a Mini-Review

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