Effects of Nanoparticle Size and Radiation Energy on Copper-Cysteamine Nanoparticles for X-ray Induced Photodynamic Therapy

Sah, Bindeshwar; Wu, Jing; Vanasse, Adam; Pandey, Nil Kanatha; Chudal, Lalit; Huang, Zhenzhen; Song, Wenzhi; Yu, Hongmei; Ma, Li; Chen, Wei; Antosh, Michael

doi:10.3390/nano10061087

Cited by 28 publications

(17 citation statements)

References 46 publications

(67 reference statements)

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“…The presence of ROS was determined by measuring the decrease in the absorbance of RNO ( p -nitrosodimethylaniline) at 440 nm in the presence of imidazole . A reaction between singlet oxygen ( 1 O 2 ) molecules and imidazole groups leads to the bleaching of RNO during the formation of a trans-annular peroxide intermediate.…”

Section: Methodsmentioning

confidence: 99%

Keratin-Based Nanoparticles with Tumor-Targeting and Cascade Catalytic Capabilities for the Combinational Oxidation Phototherapy of Breast Cancer

Lü

Wang

et al. 2021

ACS Appl. Mater. Interfaces

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Photodynamic therapy (PDT) holds tantalizing prospects of a prominent cancer treatment strategy. However, its efficacy remains limited by virtue of the hypoxic tumor microenvironment and the inadequate tumor-targeted delivery of photosensitizers, and these can be further exacerbated by the lack of development of a well-controlled nitric oxide (NO) release system at the target site. Inspired by Chinese medicine, we propose a revealing new keratin application. Keratin has garnered attention as an NO generator; however, its oncological use has rarely been investigated. We hypothesized that the incorporation of a phenylboronic acid (PBA) targeting ligand/methylene blue (MB) photosensitizer with a keratin NO donor would facilitate precise tumor delivery, enhancing PDT. Herein, we demonstrated that MB@ keratin/PBA/D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) nanoparticles (MB@ KPTNPs) specifically targeted breast cancer cells and effectively suppressed their growth. Through MB-mediated biometabolism, the endocytic MB@KPTNPs produced a sufficient amount of intracellular NO that reduced the glutathione level while boosting the efficiency of PDT. A therapeutic combination of NO/PDT was therefore achieved, resulting in significant inhibition of both in vivo tumor growth and lung metastasis. These findings underscore the importance of utilizing keratin-based nanoparticles that simultaneously combine targeting of the tumor and self-generating NO with a cascading catalytic ability as a novel oxidation therapeutic strategy for enhancing PDT.

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Section: Methodsmentioning

confidence: 99%

Keratin-Based Nanoparticles with Tumor-Targeting and Cascade Catalytic Capabilities for the Combinational Oxidation Phototherapy of Breast Cancer

Lü

Wang

et al. 2021

ACS Appl. Mater. Interfaces

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“…In addition, these rare earth doped nanoparticles also have strong scintillation luminescence that can be used for X-ray induced photodynamic therapy, which is a very hot area, as this new therapy can be used for deep as well as skin cancer treatment [ 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 ].…”

Section: Biological Applications Of Ucnpsmentioning

confidence: 99%

Recent Advances of Upconversion Nanomaterials in the Biological Field

et al. 2021

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Rare Earth Upconversion nanoparticles (UCNPs) are a type of material that emits high-energy photons by absorbing two or more low-energy photons caused by the anti-stokes process. It can emit ultraviolet (UV) visible light or near-infrared (NIR) luminescence upon NIR light excitation. Due to its excellent physical and chemical properties, including exceptional optical stability, narrow emission band, enormous Anti-Stokes spectral shift, high light penetration in biological tissues, long luminescent lifetime, and a high signal-to-noise ratio, it shows a prodigious application potential for bio-imaging and photodynamic therapy. This paper will briefly introduce the physical mechanism of upconversion luminescence (UCL) and focus on their research progress and achievements in bio-imaging, bio-detection, and photodynamic therapy.

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“…On the other hand, medium-sized nanoparticles (about 100 nm), despite producing the largest amount of ROS among the examples mentioned, did not show anti-tumor activity against B16F10 melanoma cells both in in vitro and in vivo tests. However, scientists also conducted both in vitro and in vivo tests that confirmed the anti-tumor activity of Cu-Cy nanoparticles on SW620 colon cancer cells located at the orthotropic site [ 65 ]. Cu-Cy nanoparticles coupled with pHLIP show increased radiation effect and decreased volume.…”

Section: Structure and Physicochemical Characteristics Of Coordination Complexes As Photosensitizers For Photodynamic Anticancer Therapymentioning

confidence: 99%

Coordination Complexes as a New Generation Photosensitizer for Photodynamic Anticancer Therapy

Pobłocki

Drzeżdżon

Kostrzewa

et al. 2021

IJMS

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Photodynamic therapy (PDT) has become an alternative to standard cancer treatment methods such as surgery, chemotherapy and radiotherapy. The uniqueness of this method relies on the possibility of using various photosensitizers (PS) that absorb and convert light emission in radical oxygen-derived species (ROS). They can be present alone or in the presence of other compounds such as metal organic frameworks (MOFs), non-tubules or polymers. The interaction between DNA and metal-based complexes plays a key role in the development of new anti-cancer drugs. The use of coordination compounds in PDT has a significant impact on the amount ROS generated, quantum emission efficiency (Φem) and phototoxic index (PI). In this review, we will attempt to systematically review the recent literature and analyze the coordination complexes used as PS in PDT. Finally, we compared the anticancer activities of individual coordination complexes and discuss future perspectives. So far, only a few articles link so many transition metal ion coordination complexes of varying degrees of oxidation, which is why this review is needed by the scientific community to further expand this field worldwide. Additionally, it serves as a convenient collection of important, up-to-date information.

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Effects of Nanoparticle Size and Radiation Energy on Copper-Cysteamine Nanoparticles for X-ray Induced Photodynamic Therapy

Cited by 28 publications

References 46 publications

Keratin-Based Nanoparticles with Tumor-Targeting and Cascade Catalytic Capabilities for the Combinational Oxidation Phototherapy of Breast Cancer

Keratin-Based Nanoparticles with Tumor-Targeting and Cascade Catalytic Capabilities for the Combinational Oxidation Phototherapy of Breast Cancer

Recent Advances of Upconversion Nanomaterials in the Biological Field

Coordination Complexes as a New Generation Photosensitizer for Photodynamic Anticancer Therapy

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