Effects of Naloxone on Prolactin, Luteinizing Hormone, and Cortisol Responses to Surgical Stress in Humans

Pontiroli, Antonio E.; Baio, G.; Stella, L.; Crescenti, A.; Girardi, Anna

doi:10.1210/jcem-55-2-378

Cited by 39 publications

(16 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present results show that plasma Prl increased while plasma LH decreased during stress, with the highest plasma Prl values and the lowest plasma LH values being detected in group V. It has been shown that stress stimulates Prl release (36)(37)(38) and inhibits LH release (39). Thus, the present results agree with previous reports and describe other markers (like isolation of the original group) of the stress condition in animals of group V.…”

Section: Discussionsupporting

confidence: 92%

Social condition affects hormone secretion and exploratory behavior in rats

Genaro

Schmidek

Franci

2004

Braz J Med Biol Res

View full text Add to dashboard Cite

Studies of behavior, endocrinology and physiology have described experiments in which animals housed in groups or in isolation were normally tested individually. The isolation of the animal from its group for testing is perhaps the most common situation used today in experimental procedures, i.e., there is no consideration of the acute stress which occurs when the animal is submitted to a situation different from that it is normally accustomed to, i.e., group living. In the present study, we used 90 male 120-day-old rats (Rattus norvegicus) divided into 5 groups of 18 animals, which were housed 3 per cage, in a total of 6 cages. The animals were tested individually or with their groups for exploratory behavior. Hormones were determined by radioimmunoassay using specific kits. The results showed statistically significant differences between testing conditions in terms of behavior and of adrenocorticotrophic hormone (ACTH: from 116.8 ± 15.27 to 88.77 ± 18.74 when in group and to 159.6 ± 11.53 pg/ml when isolated), corticosterone (from 561.01 ± 77.04 to 1036.47 ± 79.81 when in group and to 784.71 ± 55.88 ng/ml when isolated), luteinizing hormone (from 0.84 ± 0.09 to 0.58 ± 0.05 when in group and to 0.52 ± 0.06 ng/ml when isolated) and prolactin (from 5.18 ± 0.33 to 9.37 ± 0.96 when in group and to 10.18 ± 1.23 ng/ml when isolated) secretion, but not in terms of follicle-stimulating hormone or testosterone secretion. The most important feature observed was that in each cage there was one animal with higher ACTH levels than the other two; furthermore, the exploratory behavior of this animal was different, indicating the occurrence of almost constant higher vigilance in this animal (latency to leave the den in group: 99.17 ± 34.95 and isolated: 675.3 ± 145.3 s). The data indicate that in each group there is an animal in a peculiar situation and its behavior can be detected by ACTH determination in addition to behavioral performance.

show abstract

Section: Discussionsupporting

confidence: 92%

Social condition affects hormone secretion and exploratory behavior in rats

Genaro

Schmidek

Franci

2004

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…The methods used in the present study appeared to be the best possible approach, given that OGTT cannot be performed earlier, as it would be difficult to interpret due to fasting, to anesthesia, and to endocrine disturbances that last long after surgery [19,20]. It has also to be considered that changes of body weight with both BPD and LGB were quite reduced from the biological point of view.…”

Section: Discussionmentioning

confidence: 99%

Early Effects of Gastric Banding (LGB) and of Biliopancreatic Diversion (BPD) on Insulin Sensitivity and on Glucose and Insulin Response after OGTT

2010

Self Cite

View full text Add to dashboard Cite

show abstract

“…The pathways mediating stress-related prolactin release are unclear but opioid peptides, in particular b-endorphins, play a role. 7 In contrast, melanocyte-stimulating hormone (MSH) appears to inhibit stress-induced increases.…”

Section: Regulation Of Prolactin Secretionmentioning

confidence: 99%

Physiopathology of prolactin secretion in obesity

Kopelman

2000

Int J Obes

View full text Add to dashboard Cite

In many species prolactin is of biological importance and has a major role in determining the deposition and mobilization of fat. In human physiology, outside pregancy, prolactin secretion is altered by increasing body weight in both children and adults. Prolactin in this circumstance appears to be marker of hypothalamic ± pituitary function: the prolactin response to insulin-hypoglycaemia, thyrotrophin releasing hormone stimulation and other stimulatory factors may be diminished. In addition, obesity alters the 24 h spontaneous release of prolactin with a generalised dampening of release. A number of explanations have been given as possible causes for these alterations, but it seems likely that they re¯ect obesity per se and are associated with hyperinsulinaemia. Weight reduction, with accompanying decrease in plasma insulin levels, leads to a normalization of prolactin responses in most, but not all, circumstances. To date, no molecular basis has been identi®ed which links prolactin with increasing body fatness, weight and appetite: new data suggests a possible link in obese men between fasting plasma prolactin and leptin concentrations.

show abstract

Effects of Naloxone on Prolactin, Luteinizing Hormone, and Cortisol Responses to Surgical Stress in Humans

Cited by 39 publications

References 15 publications

Social condition affects hormone secretion and exploratory behavior in rats

Social condition affects hormone secretion and exploratory behavior in rats

Early Effects of Gastric Banding (LGB) and of Biliopancreatic Diversion (BPD) on Insulin Sensitivity and on Glucose and Insulin Response after OGTT

Physiopathology of prolactin secretion in obesity

Contact Info

Product

Resources

About