Effects of nadolol on the spontaneous and exercise-provoked heart rate of patients with chronic atrial fibrillation receiving stable dosages of digoxin

DiBianco, Robert; Morganroth, Joel; Freitag, Judith A.; Ronan, James A.; Lindgren, Keith M.; Donohue, Dennis J.; Larca, Louis J.; Chadda, Kul D.; Olukotun, Adeoye Y.

doi:10.1016/0002-8703(84)90592-1

Cited by 92 publications

(22 citation statements)

References 27 publications

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“…Beta-adrenergic blockers. By using nadolol plus digoxin, mean and exercise HRs can be reduced, as compared with digoxin, and the exercise time can be reduced too (23). The beta 1 -selective drug, celiprolol, can improve HR control to exercise at the expense of decreased exercise capacity and oxygen consumption (24).…”

Section: Discussionmentioning

confidence: 99%

The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study

Olshansky¹,

Rosenfeld²,

Warner³

et al. 2004

Journal of the American College of Cardiology

353

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Section: Discussionmentioning

confidence: 99%

The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study

Olshansky¹,

Rosenfeld²,

Warner³

et al. 2004

Journal of the American College of Cardiology

353

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show abstract

“…It was expected that exercise capacity would improve due to a reduction in heart rate. Surprisingly, however, later studies showed no improvement of exercise capacity with a more physiological rate response during exercise [27][28][29][30][31][32][33].…”

Section: Rationale To Initiate the Race II Studymentioning

confidence: 99%

Rate control in atrial fibrillation, insight into the RACE II study

et al. 2013

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“…Once patients completed all PF trials, P trials were performed. In order to accomplish this, a common clinical protocol was used where each patient was asked to walk on an inclined treadmill with 10% grade at a speed of 1.5 mph (DiBianco et al, 1984) until claudication pain was established. The patients were then immediately removed from the treadmill and returned to the collection walk-way to acquire the data for the P condition without the mandatory resting periods.…”

Section: Experimental Procedures and Data Collectionmentioning

confidence: 99%

Bilateral claudication results in alterations in the gait biomechanics at the hip and ankle joints

Chen

Pipinos

Johanning

et al. 2008

Journal of Biomechanics

100

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Claudication is the most common symptomatic manifestation of peripheral arterial disease (PAD), producing significant ambulatory compromise. The purpose of this study was to use advanced biomechanical gait analysis to determine the gait alterations occurring in claudicating patients both before and after onset of claudication pain in their legs. Hip, knee, and ankle joint moments were measured in claudicating patients (age: 64.4678.47 years; body mass: 80.70712.64 kg; body height: 1.7270.08 m) and were compared to gender-age-body mass-height-matched healthy controls (age 66.2779.22 years; body mass: 77.89710.65 kg; body height: 1.7470.08 m). The claudicating patients were evaluated both before (pain-free (PF) condition) and after (pain condition) onset of claudication pain in their legs. Thirteen symptomatic PAD patients (26 claudicating limbs) with bilateral intermittent claudication (IC) and 11 healthy controls (22 control limbs) were tested during level walking at their self-selected speed. Compared to controls, PAD hip and ankle joints demonstrated significant angular kinematics and net internal moment changes. Alterations were present both in PF and pain conditions with several of them becoming worse in the pain condition. Both PF and pain conditions resulted in significantly reduced peak hip extensor moment (5.6271.40 and 5.6371.33% BW Â BH, respectively) during early stance as compared to controls (7.5371.16% BW Â BH). In the pain condition, PAD patients had a significantly reduced ankle plantar flexor moment (7.5671.41% BW Â BH) during late stance as compared to controls (8.6571.27% BW Â BH). Furthermore, when comparing PF to pain conditions, there was a decreased peak plantar flexor moment (PF condition: 8.2371.37 vs. pain condition: 7.5671.41% BW Â BH) during late stance. The findings point to a weakness in the posterior compartment muscles of the hip and calf as being the key factor underlying the PAD gait adaptations.Our findings establish a detailed baseline description of the changes present in PAD patient's joint angles and moments during walking. Since IC is primarily a gait disability, better understanding of the abnormalities in joint and muscle function will enhance our understanding of the gait impairment and may lead to novel, gait-specific treatments. r

show abstract

Effects of nadolol on the spontaneous and exercise-provoked heart rate of patients with chronic atrial fibrillation receiving stable dosages of digoxin

Cited by 92 publications

References 27 publications

The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study

The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study

Rate control in atrial fibrillation, insight into the RACE II study

Bilateral claudication results in alterations in the gait biomechanics at the hip and ankle joints

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