EFFECTS OF n-DECYLAMINE AND TOLUIDINE BLUE ON THE ELECTRIC CAPACITANCE OF ISOLATED RAT MAST CELLS

Abstract

(5) proved that in muscle fiber, the larger compo nent of the capacitance can be related to the inside structure of the cell (the transverse tubular system) rather than cell membranes. The mast cell contained a number of granules sur rounded by double-layered membranes which may correspond in some way to the transverse tubular system in the muscle fiber.It is generally considered that histamine releasing agents may affect the receptive sites on the cell membrane of the rat mast cells and this drug-cell surface interaction triggers a series of events leading to histamine release primarily around the cell membrane (6).

Time–resolved capacitance measurements: monitoring exocytosis in single cells

“…A first attempt in 1978 to measure the capacitance of resting and stimulated mast cells was made with extracellular electrodes on mast cells in suspension passing through a narrow pore (Tasaka et al 1978). After stimulation with low concentrations of toluidine blue a capacitance increase of 35 % was obtained but at higher concentrations an apparent decrease of capacitance was reported.…”