Effects of N-Arachidonoyl Dopamine, Haloperidol, and Their Mixtures on Regeneration of Freshwater Hydra attenuata

Markova, L. N.; Ostroumova, T. V.; Безуглов, В. В.; Buznikov, G. A.

doi:10.1023/b:rudo.0000043824.95991.a4

Cited by 1 publication

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data obtained indicate that conjugates of unsaturated fatty acids with neuromediators can also be a factor controlling hydra morphogenesis (Markova et al, 2004). In this work, NADA not only accelerated tentacle formation but also inverted natural differences in the rate of tentacle formation between the gastral and basal fragments.…”

Section: Discussionsupporting

confidence: 55%

“…Previously, we have shown that inhibitors of dopamine synthesis and dopamine antagonists affect regeneration in hydra and induce abnormal morphogenesis of the gastral fragment (Ostroumova and Markova, 2000). Our previous study has demonstrated different responses of different hydra fragments exposed to NADA, haloperidol (a dopamine receptor blocker), and their mixture (Markova et al, 2004). Our previous study has demonstrated different responses of different hydra fragments exposed to NADA, haloperidol (a dopamine receptor blocker), and their mixture (Markova et al, 2004).…”

mentioning

confidence: 94%

See 1 more Smart Citation

10.1007/s11174-008-1009-1

2010

CrossRef Listing of Deleted DOIs

View full text Add to dashboard Cite

The effect of N-arachidonoyl dopamine, haloperidol, and their mixture on the rate of tentacle formation was studied during regeneration of the gastral and basal fragments of freshwater hydra. Some concentrations of haloperidol inhibited the tentacle formation, which was more pronounced in the basal fragment. N-arachidonoyl dopamine accelerated the tentacle formation in both fragments, particularly, in the basal one (an inversion of the natural difference in the rate of tentacle formation between the gastral and basal fragments). After the exposure to the mixture of these drugs, the effects of each of them were observed. Mass spectrometry assay has demonstrated endogenous N-arachidonoyl dopamine in the intact hydra homogenate. The possible involvement of this acyl-neurotransmitter in the regulation of the rate of tentacle formation in regenerating hydra is discussed.

show abstract

Section: Discussionsupporting

confidence: 55%

mentioning

confidence: 94%