Effects of N-acetylcysteine on oxidative responses in the liver of fenthion exposed Cyprinus carpio

Sevgiler, Yusuf; Piner, Petek; Durmaz, Hülya; Üner, Nevin

doi:10.1016/j.pestbp.2006.08.003

Cited by 35 publications

(25 citation statements)

References 37 publications

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“…This indicated that the critical balance between oxidants and antioxidants was disrupted and the defense mechanism of antioxidants was declined in fish under trichlorfon stress. Previous studies also reported that methyl parathion, macrophages, chlorpyrifos, fenthion all could induce oxidative stress as shown by the enhancement of MDA production (Monteiro et al 2006;Sevgiler et al 2007;Kavitha and Rao 2008;Tellez-Bañuelos et al 2009). Those peroxidation productions accumulated in hepatocytes and resulted in changes in hepatocellular ultrastructure and induced apoptosis (Xu et al 2009).…”

Section: Discussionmentioning

confidence: 85%

Effect of trichlorfon on oxidative stress and hepatocyte apoptosis of Carassius auratus gibelio in vivo

Liu

et al. 2011

Fish Physiol Biochem

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To investigate the effect of trichlorfon on oxidative stress and hepatocyte apoptosis of Carassius auratus gibelio in vivo, the fish were exposed to 0, 0.5, 1.0, 2.0 and 4.0 mg l(-1) trichlorfon concentrations for 30 days. At the end of the experiment, plasm antioxidant activities, hepatic total nitric oxide synthase (T-NOS) activity, xanthine oxidase (XOD) activity and hepatocyte apoptosis rate were analyzed. The results showed hepatic T-NOS activities, XOD activities and hepatocyte apoptosis rate were increased with trichlorfon concentration increase. The hepatic MDA content was increased significantly at 4.0 mg l(-1) trichlorfon treatment. The disturbance of antioxidative balance was observed based on the monitoring of the plasm superoxide dismutase (SOD), catalase (CAT) activities and vitamin E levels. The current study revealed that trichlorfon influenced fish plasma antioxidative status, caused lipid peroxidation (LPO) then resulted in hepatocytes apoptosis.

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Section: Discussionmentioning

confidence: 85%

Effect of trichlorfon on oxidative stress and hepatocyte apoptosis of Carassius auratus gibelio in vivo

Liu

et al. 2011

Fish Physiol Biochem

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“…These substances frequently cause damage to lipids, proteins, carbohydrates and nucleic acids Ü ner et al 2005;Ortiz-Ordonez et al 2011). Cells have an antioxidant defense system to neutralize the effects of free radicals such as superoxide anion radicals (O 2 Á-) and hydroxyl radicals (HO Á ) (Monteiro et al 2006;Sevgiler et al 2007). The measurement of thiobarbituric acid-reactive substances (TBARS), antioxidant enzymes and metabolic parameters in fish organs has been frequently used to assess environmental contamination (Modesto and Martinez 2010;Moraes et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Commercial formulation containing 2,4-D affects biochemical parameters and morphological indices of silver catfish exposed for 90 days

Menezes

Fonseca

Leitemperger

et al. 2014

Fish Physiol Biochem

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The objective of this study was to verify whether a commercial formulation of 2,4 dichlorophenoxyacetic acid [2,4-D dimethylamine salt (DMA)] affects the growth and biochemical parameters of silver catfish (Rhamdia quelen) after 90 days of exposure. The fish exposed to 0.5 or 2.0 mg/L of DMA presented exhibited decreased growth parameters. Glucose was reduced in the mucus layer at both concentrations, and the total protein level was increased at the highest concentration tested. Fish exposed to DMA showed reduced liver and kidney glycogen at both concentrations tested, while in the muscle, glycogen was reduced only at 2.0 mg/L. Glucose was increased in the liver and decreased in the muscle and kidney at both concentrations and was not altered in the plasma. Lactate was increased in all the tissues and decreased in the plasma. Protein levels were reduced in the liver and plasma at both concentrations, while in the muscle, it was decreased at a concentration of 2.0 mg/L. Levels of thiobarbituric acid-reactive substances were reduced in the liver and increased in the muscle at both concentrations and did not change in the brain. DMA increased catalase activity in the liver at both concentrations tested. The present study demonstrates the effects of long-term exposure to DMA. Some parameters could be used as toxicity indicators to identify the presence of DMA in an aquatic environment.

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“…Oxidative stress occurs when there is a disruption in the balance between the production and the removal of ROS and other free radicals (Santos et al, 2004;Ortiz-Ordoñez et al, 2011). The highest susceptible targets of oxidative stress are polyunsaturated fatty acids and proteins of the cell membrane (Sevgiler et al, 2007). In mammals, it is known that damage to proteins and amino acids could be attributed to increased protein carbonyl levels (Parvez & Raisuddin, 2005).…”

Section: Introductionmentioning

confidence: 99%

Glyphosate-based herbicide affects biochemical parameters in Rhamdia quelen (Quoy & Gaimard, 1824 and) Leporinus obtusidens (Valenciennes, 1837)

et al. 2015

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Rhamdia quelen (silver catfish) and Leporinus obtusidens (piava) were exposed to a commercial formulation Roundup ® , a glyphosate-based herbicide at concentrations of 0.2 or 0.4 mg/L for 96 h. The effects of the herbicide were analyzed on the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and glucose in plasma, glucose and protein in the mucus layer, nucleotide hydrolysis in the brain, and protein carbonyl in the liver. The parameters were chosen, owing to a lack of information concerning integrated analysis, considering oxidative damage parameters, liver damage, and effects on the mucus layer composition and triphosphate diphosphohydrolase (NTPDase) activities. Plasmatic glucose levels were reduced in both species, whereas the transaminase activities (ALT and AST) increased after exposure to the herbicide. Herbicide exposure increased protein and glucose levels in the mucus layer in both species. There was a reduction in both NTPDase and ecto-5'-nucleotidase activity in the brain of piava, and increased enzyme activity in silver catfish at both concentrations tested. The species showed an increase in protein carbonyl in the liver after exposure to both concentrations of the glyphosate. Our results demonstrated that exposure to Roundup ® caused liver damage, as evidenced by increased plasma transaminases and liver protein carbonyl in both of the fish species studied. The mucus composition changed and hypoglycemia was detected after Roundup ® exposure in both species. Brain nucleotide hydrolysis showed a different response for each fish species studied. These parameters indicated some important and potential indicators of glyphosate contamination in aquatic ecosystems.Rhamdia quelen (jundiá) e Leporinus obtusidens (piava) foram expostos a formulação comercial Roundup ® , um herbicida a base de glifosato nas concentrações de 0,2 e 0,4 mg/L por 96h. Os efeitos do herbicida foram analisados na atividade da alanina aminotransferase (ALT), aspartato aminotransferase (AST) e glicose no plasma, glicose e proteína na camada de muco, hidrólise de nucleotídeos no cérebro e a proteína carbonil no fígado. Os parâmetros foram escolhidos devido à falta de informação com relação a análises integradas, considerando parâmetros oxidativo, danos no fígado, efeitos na composição da camada do muco e atividade da trifosfato difosfoidrolase (NTPDase). Níveis de glicose plasmática foram reduzidos em ambas às espécies, enquanto a atividade das transaminases (ALT e AST) aumentou após exposição ao herbicida. A exposição ao herbicida aumentou a proteína e níveis de glicose na camada de muco em ambas as espécies. Houve uma redução em ambas atividades de NTPDase e ecto-5'-nucleotidase no cérebro de piava, e um aumentou a atividade destas enzimas em jundiás em ambas as concentrações testadas. As espécies mostraram um aumento na proteína carbonil no fígado após exposição a ambas as concentrações de glifosato. Nossos resultados demonstraram que a exposição ao Roundup ® causou danos no fígado, como evidenciado pel...

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Effects of N-acetylcysteine on oxidative responses in the liver of fenthion exposed Cyprinus carpio

Cited by 35 publications

References 37 publications

Effect of trichlorfon on oxidative stress and hepatocyte apoptosis of Carassius auratus gibelio in vivo

Effect of trichlorfon on oxidative stress and hepatocyte apoptosis of Carassius auratus gibelio in vivo

Commercial formulation containing 2,4-D affects biochemical parameters and morphological indices of silver catfish exposed for 90 days

Glyphosate-based herbicide affects biochemical parameters in Rhamdia quelen (Quoy & Gaimard, 1824 and) Leporinus obtusidens (Valenciennes, 1837)

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