Effects of N-Acetyl-L-Cystein Antioxidant on <i>Ex Vivo</i> Culture of Vitrified Premature Mouse Ovarian Tissue

Eivazkhani, Farideh; Ebrahimi, Bita; Yousefi, Behpour; Fathi, Rouhollah; Akbarinejad, Vahid

doi:10.1089/bio.2021.0147

Cited by 4 publications

(2 citation statements)

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“…Recently, Gliszczynska et al, explored sesquiterpene coumarins, focusing on ferulenol, as promising lead compounds for drug discovery 30 . Notably, this diverse array of secondary metabolites substantially contributes to the antioxidant capabilities of F. communis while simultaneously conferring a broad spectrum of pharmacological and biological functionalities 31 . Phenolic acids, known for their various biological applications, are the primary polyphenols produced by plants and serve as precursors for bioactive molecules used in the therapeutic, cosmetic, and food industries.…”

Section: Resultsmentioning

confidence: 99%

“…As antioxidant test models vary in different respects, it is difficult to directly compare results 9 , 34 . Therefore, performing several screens using ex vivo models and in vivo studies is essential 31 . DPPH is a nitrogenous organic radical with free electrons, and is an easy and valuable spectrophotometric method for screening or measuring antioxidant activity 38 .…”

Section: Resultsmentioning

confidence: 99%

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Comprehensive analysis of different solvent extracts of Ferula communis L. fruit reveals phenolic compounds and their biological properties via in vitro and in silico assays

Nouioura,

El fadili,

El Barnossi

et al. 2024

Sci Rep

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Although giant fennel is recognized as a “superfood” rich in phytochemicals with antioxidant activity, research into the antibacterial properties of its fruits has been relatively limited, compared to studies involving the root and aerial parts of the plant. In this study, seven solvents—acetone, methanol, ethanol, ethyl acetate, chloroform, water, and hexane—were used to extract the chemical constituents of the fruit of giant fennel (Ferula communis), a species of flowering plant in the carrot family Apiaceae. Specific attributes of these extracts were investigated using in silico simulations and in vitro bioassays. High-performance liquid chromatography equipped with a diode-array detector (HPLC–DAD) identified 15 compounds in giant fennel extract, with p-coumaric acid, 3-hydroxybenzoic acid, sinapic acid, and syringic acid being dominant. Among the solvents tested, ethanol demonstrated superior antioxidant activity and phenolic and flavonoid contents. F. communis extracts showed advanced inhibition of gram-negative pathogens (Escherichia coli and Proteus mirabilis) and variable antifungal activity against tested strains. Molecular docking simulations assessed the antioxidative, antibacterial, and antifungal properties of F. communis, facilitating innovative therapeutic development through predicted compound–protein interactions. In conclusion, the results validate the ethnomedicinal use and potential of F. communis. This highlights its significance in natural product research and ethnopharmacology.

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Section: Resultsmentioning

confidence: 99%