Effects of N-acetyl-L-carnosine aluminum (CL-1700) on various acute gastric lesions and gastric secretion in rats.

Okabe, Susumu; Kunimi, Haruyo

doi:10.1254/jjp.31.941

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…AAHA, has been reported to have a potent inhibitory effect on the formation of various types of acute gastric ulcers or erosions in rats (25). It was proved from the present study that AAHA had a stimulatory effect on the SGP synthesis, particulary the synthesis of highly sulfated glycoproteins at 12 hr after the onset of stress.…”

supporting

confidence: 58%

Changes in the Incorporating Activity of 35S-Sulfate into Gastric Sulfated Glycoproteins in the Rat with Erosions by Restraint and Water Immersion Stress

Murakami

Mori

1984

Japanese Journal of Pharmacology

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Abstract-The synthetic activity of rat gastric sulfated glycoproteins (SGP) in vitro was investigated at various time intervals after water immersion stress using 3 5 Ssulfate as a precursor. More than 90 percent of the total radioactivity was incorporated into mucosal SGP, and the rest was incorporated into glycosaminoglycans in the gastric muscular layer. The incorporation of 35S-sulfate into SGP increased at 2 hr and decreased at 6 hr after the onset of stress. The incorporating activity again increased markedly at 12 hr and then recovered to the normal level at 24 hr after the onset of stress. An anti-ulcer agent, N-(N-acetyl-8-alanyI)-L-histidine aluminum complex (AAHA), significantly increased the SGP synthetic activity at 12 hr and at 24 hr after the onset of stress. It was indicated from the elution patterns on the DEAE-cellulose column that AAHA increased the amount of highly sulfated glycoproteins compared with the stress control at 12 hr after the onset of stress. The uronic acid content in the gastric muscular layer of the rat was unchanged with stress. These results in the in vitro experiment indicate that the SGP synthetic activity does not decrease with stress load, but rather increases at 2 hr and at 12 hr after the onset of stress when a sufficient amount of 35S-sulfate is supplied. Accordingly, it is suggested that SGP facilitates the restoration of the gastric mucosal damage caused by stress.

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supporting

confidence: 58%

Changes in the Incorporating Activity of 35S-Sulfate into Gastric Sulfated Glycoproteins in the Rat with Erosions by Restraint and Water Immersion Stress

Murakami

Mori

1984

Japanese Journal of Pharmacology

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“…We showed in a previous report that CL 1700 (N-acetyl-L-carnosine aluminum), a new compound, had potent inhibitory effects on the formation of acute gastric lesions in rats (1). CL-1700 is a complex of N-acetyl L-carnosine which is derived from L carnosine and AI(OH)3.…”

Section: Abstract-effectsmentioning

confidence: 97%

“…The dose of CL-1700 used in this study is the one which was effective on several gastric lesions in rats as shown in previous experiments (1). The doses of L-carnosine, N-acetyl-L-carnosine, and AI(OH)3 were selected according to the ratio of each of their molecular weights to the molecular weight of CL-1700 according to the composition of C L-1700.…”

Section: Abstract-effectsmentioning

confidence: 99%

Effects of Cl-1700 and Its Constituents on Acute or Chronic Gastric Lesions and Gastric Secretion in Rats

Kunimi¹,

Okabe²

1982

Jpn.J.Pharmacol

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“…We have reported that CL-1700 (N acetyl-L-carnosine aluminum) has a potent antiulcer effect on both acute and chronic types of gastric ulcers in rats (1). In addition, we found that the effects of CL-1700 are much more potent than its constituents, L carnosine, N-acetyl-L-carnosine or AI(OH)3, to inhibit the development of different forms of induced acute gastric ulcers (2).…”

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confidence: 90%

Effects of CL-1700 on duodenal ulcer formation in the rat.

Kunimi¹,

Okabe²

1982

Jpn.J.Pharmacol

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We have reported that CL-1700 (N acetyl-L-carnosine aluminum) has a potent antiulcer effect on both acute and chronic types of gastric ulcers in rats (1). In addition, we found that the effects of CL-1700 are much more potent than its constituents, L carnosine, N-acetyl-L-carnosine or AI(OH)3, to inhibit the development of different forms of induced acute gastric ulcers (2). The present experiment was done to determine whether CL-1700 also has an antiduodenal ulcer activity in two types of duodenal ulcer models in rats. AI(OH)3, pirenzepine 2HCI, cimetidine, and aluminum sucrose sulfate were used as reference drugs.Male Sprague-Dawley rats (210-230 g) were divided into two groups. In one group, mepirizole (Daiichi) at 200 mg/kg, suspended in 1 % carboxymethylcellulose (CMC) solu tion, was given to normally fed rats by gastric intubation in a volume of 0.5 ml/100 g of body weight (3, 4). The animals were killed under ether anesthesia 24 hr after the adminis tration of mepirizole. The duodenum and stomach of each rat were taken together, inflated with 12 ml of 2% formalin solution, and immersed in 2% formalin solution for 10 min. After fixing, only the duodenum was incised along the antimesenteric border and the area (mm2) of the ulcers was measured under a dissecting microscope (10X) with a square grid. The sum of the area of each ulcer in the duodenum was taken as the ulcer index. The person measuring the area of ulceration was unaware of which treatment the animals had been given. Test compounds, either dissolved or suspended in distilled water, were given p.o. twice (once, 10 min before the administration of mepirizole and again, 9 hr after the administration of mepirizole) or thrice (once, 10 min before the adminis tration of mepirizole and again, 5 and 10 hr after the administration). Control animals received distilled water only. In another group, histamine 2HCI (40 mg/kg)+ carbachol (0.08 mg/kg), dissolved in saline solution containing 16% gelatin, was given s.c. to 24 hr-fasted rats hourly, 10 times, in a volume of 0.05 ml/100 g of body weight. This method is a modification of the original method described by Robert et al. (5), who developed duodenal ulcers by a continuous s.c. infusion of histamine 2HCI+carbachol solution for 48 hr. Animals were killed under ether anesthesia 15 hr after the final adminis tration of histamine 2HCI+carbachol solution. The duodenum and stomach were taken together and then treated with 2% formalin solution, as previously described. The areas (mm2) of all ulcers developed in the duodenum were measured. Since the ulcers varied in size from small to large in each rat, the sum of the ulcerated area was divided into 6 degrees as the ulcer index.

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Effects of N-acetyl-L-carnosine aluminum (CL-1700) on various acute gastric lesions and gastric secretion in rats.

Abstract: Abstract-Effects of a newly synthesized compound.

Cited by 7 publications

References 12 publications

Changes in the Incorporating Activity of 35S-Sulfate into Gastric Sulfated Glycoproteins in the Rat with Erosions by Restraint and Water Immersion Stress

Changes in the Incorporating Activity of 35S-Sulfate into Gastric Sulfated Glycoproteins in the Rat with Erosions by Restraint and Water Immersion Stress

Effects of Cl-1700 and Its Constituents on Acute or Chronic Gastric Lesions and Gastric Secretion in Rats

Effects of CL-1700 on duodenal ulcer formation in the rat.

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