Effects of myrrh on intra-oral mucosal wounds compared with tetracycline- and chlorhexidine-based mouthwashes

Al-Mobeeriek, Azizah

doi:10.2147/cciden.s24064

Cited by 17 publications

(14 citation statements)

References 26 publications

(28 reference statements)

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“…Three types of experimental media containing varying concentrations of myrrh were used. TG-1 contained 0.2% myrrh, which is the most common practice of myrrh use in the Saudi population 30) . TG-2 contained 100% myrrh oil, a supraphysiologic test solution, which was used to determine whether myrrh would cause suture material deterioration at higher concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence suggests that myrrh can be used to treat ulcers, fasciolopsis, respiratory catarrh, furunculosis, and diabetes [24][25][26][27][28][29] . A tincture of myrrh in alcohol is typically used as an oral astringent and mouthwash, especially for treating painful throat infections 30) . Traditionally, myrrh was used to treat sore throats and cough, burns, external wounds, and even joint inflammation and tendonitis 31) .…”

Section: Introductionmentioning

confidence: 99%

“…Evidence suggests that toothpastes and mouthwashes which contain myrrh are effective in preventing and treating gingival inflammation 35,36) . In a recent animal study by Al-Mobeeriek 30) , a dilute myrrh suspension was found to promote the healing and repair of damaged oral tissues. The same study reported possible harmful effects of myrrh when used in excess or over long periods due to either overdosing or inherent adverse reactions to myrrh.…”

Section: Introductionmentioning

confidence: 99%

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Effects of myrrh on the strength of suture materials: an <i>in vitro</i> study

Alshehri

Baskaradoss

Geevarghese

et al. 2015

Dental Materials Journal

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The present in vitro study sought to determine the effects of myrrh-containing solutions on common suture materials used in periodontal surgery. Three commonly used suture materials (silk, polyglactin 910, polytetrafluoroethylene) were immersed in four thermostatically controlled experimental media to simulate daily oral rinsing activity, namely -artificial saliva, normal saline solution with 0.2% Commiphora myrrh, full-concentration (100%) Commiphora myrrh oil, and a myrrh-containing commercial mouthwash. Tensile strength was measured at the end of each day using an Instron tensile testing machine. Silk sutures were susceptible to tensile strength loss when exposed to 0.2% myrrh solution once daily for 5 days. Myrrh-containing commercial mouthwash had no effect on tensile strength, but all three suture materials lost tensile strength when exposed to 100% myrrh oil. For patients that routinely use myrrh mouthwashes postoperatively, findings of this study suggested that silk sutures might not be the optimal material choice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of myrrh on the strength of suture materials: an <i>in vitro</i> study

Alshehri

Baskaradoss

Geevarghese

et al. 2015

Dental Materials Journal

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“…It is found that myrrh suspension in low quantities is effective and produces clinical benefits as a mouthwash, especially when treating intra-oral mucosal wounds [40]. Additionally, a pilot clinical study that examined the effects of using C. myrrh as mouthwash supported the antiplaque and anti-inflammatory activities [41].…”

Section: Effect Of Myrrh In the Oral Cavitymentioning

confidence: 99%

Can Myrrh Combat COVID-19?

Alyafei¹

2020

Iberoam J Med

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This paper reviews the therapeutic effects of Commiphora myrrh in different diseases. It is organized by sub-themed sections: nature and history of myrrh, its use in different cultures, its chemical action, and effect on virus or/and bacteria, benefits of its utilization for respiratory problems and oral diseases. A literature research for the Myrrh or C. myrrh was performed using Cochrane Library databases and Medline. Forty two papers, including abstracts and full articles published from 2007 to 2020, in the area of interest were reviewed. It was found that Myrrh or C. myrrh is one of the medicinal plants believed to have therapeutic effects in various diseases. It has medicinal properties, such as immunomodulatory, anti-inflammatory, cytotoxic, antioxidant, antimicrobial, hepatoprotective, anti-tumor, anti-ulcer, and analgesic activities. Besides, Myrrh has also shown to have antiviral properties that help in preventing different types of viral diseases. It noticed in the State of Qatar, sales of herbs and Myrrh has escalade since the surgency of COVID-19 cases, so is there a belief in Myrrh's effectiveness to be used during COVID-19? Studying the effectiveness of Myrrh mouthwashes to combat COVID-19 can emerge as a promising avenue in the field of research.

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“…It has been reported that the myrrh can be used in the treatment of ulcers, Schistosoma , Fasciolopsis , respiratory catarrh, Furunculosis , and diabetes [5, 6]. Myrrh was also found to promote permeability of medicine from epidermis to dermal capillaries and also enhance the wound healing process [7, 8]. It consists of various chemical constituents like cadinene, elemol, eugenol, cuminaldehyde, numerous furanosesquiterpenes including furanogermacranes, furanodiene, furanodienone, curzerene, and lindestrene, as well as furanoeudesma-1,3-diene [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Subcutaneous Injection of Myrrh Essential Oil in Mice: Acute and Subacute Toxicity Study

Lamichhane

Lee

Pandeya

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Myrrh essential oil (MEO) is widely used as remedies for the different human ailment in different parts of the world. The misuse of this natural product in higher doses may lead to fever, inflammation, and liver and kidney problems. In this study, we performed the acute and subacute toxicity analysis of MEO in mice model after subcutaneous injection and evaluated the safe dose to prevent the possible risk and side effects. Initially (first phase study) higher dose of MEO (20, 40, and 80 μL) was injected, and later in the second phase study lower dose of MEO (1, 5, and 10 μL) was injected for three days in each group of mice. Blood samples were taken for the investigation of hematological parameters and activity of various enzymes. The liver, kidney, spleen, lungs, and heart were excised for histological study. The body weight and skin abnormalities were also evaluated. In the first phase study, the mice showed granuloma formation at the site of injection. The liver showed dilated sinusoids and enlarged central vein. In the spleen the distinction between red and white pulp was lost. The kidney showed the degeneration of glomerulus. The enzyme activity and body weight were also decreased by the higher dose. The WBC count also increased nearly by twofold. Pruritus and self-trauma were also evident. Later in the second phase study, the skin abnormalities (granuloma) and damage in the structure of tissue (in liver, spleen, and kidney) were absent along with no change in enzyme levels, blood parameters, and body weight compared to the control. The MEO was toxic to liver, spleen, and kidney in the higher doses. The safe volume of MEO useful for various studies in mice was evaluated. The safe use of MEO should be assured, it should not be misused, being considered as a natural remedy, and there should be awareness of its toxicity and side effects.

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Effects of myrrh on intra-oral mucosal wounds compared with tetracycline- and chlorhexidine-based mouthwashes

Cited by 17 publications

References 26 publications

Effects of myrrh on the strength of suture materials: an <i>in vitro</i> study

Effects of myrrh on the strength of suture materials: an <i>in vitro</i> study

Can Myrrh Combat COVID-19?

Subcutaneous Injection of Myrrh Essential Oil in Mice: Acute and Subacute Toxicity Study

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