Effects of Myricetin‐Containing Ethanol Solution on High‐Fat Diet Induced Obese Rats

Abstract

Myricetin is a natural flavonol widely occurring in wines. Many beneficial effects of myricetin in alcoholic beverages have been reported before, but never including anti-obesity. In the present study, we fed obese male Sprague-Dawley rats with ethanol solutions containing various concentrations of myricetin and found that myricetin may maintain the food intake while reduce the weight-gain, feed efficiency, level of blood lipids, adipocyte size, and weight and size of the perirenal and epididymal adipose tissues (P < 0.01). Our experiment data also show that the anti-obesity effect may be associated with the upregulation of adropin and β-endorphin levels. Based on the above-described findings, we propose the potential for myricetin-containing alcoholic beverages to be developed into anti-obesity health food.

Myricetin ameliorates atherosclerosis in the low-density-lipoprotein receptor knockout mice by suppression of cholesterol accumulation in macrophage foam cells

“…Recent studys have demonstrated many health benefits of myricetin including antioxidative [21], anticarcinogenic [22], antiplatelet activities [10], cytoprotective effects [23], anti-obesity [16], improving glucose utilization [17] and plasma lipids profile [15]. In our study, myricetin treatment reduced body weight but not food intake, this anti-obesity effect is consistent with previous findings [16]. When Ldlr −/− mice were fed an AsD for 8 weeks, plasma cholesterol reached as high as 1300 mg/dL.…”

“…Myricetin has been shown to possess anti-inflammation and antioxidation properties [12, 13]. And, myricetin has also demonstrated the ability to anti-obesity, improve glucose utilization, modulate lipid metabolism [14–16]. It was reported that myricetinreduced the weight-gain, feed efficiency, level of blood lipids, adipocyte size, and weight and size of the perirenal and epididymal adipose tissues [16].…”

“…And, myricetin has also demonstrated the ability to anti-obesity, improve glucose utilization, modulate lipid metabolism [14–16]. It was reported that myricetinreduced the weight-gain, feed efficiency, level of blood lipids, adipocyte size, and weight and size of the perirenal and epididymal adipose tissues [16]. This anti-obesity effect may be involved in upregulation of adropin and β-endorphin levels.…”

Myricetin: A comprehensive review on its biological potentials

“…In mouse adipocyte 3T3-L1 cells, myricetin significantly reduced phosphorylated Akt levels (Yao et al, 2018). Reduction in feed efficiency, weight gain, adipocyte size, weight and size of the epididymal and perirenal adipose tissues, level of blood lipids, as well as upregulation of β-endorphin and adropin levels were reported after myricetin treatment in obese male Sprague-Dawley rats (Chao et al, 2017).…”

The Protective Effects of Myricetin against Cardiovascular Disease

“…Myr may prevent obesity and obesity-related metabolic complications, while also exhibiting reversing hepatic steatosis caused by high-fat diets. Previously, Chao et al (44) reported on the anti-obesity effects of Myr using male Sprague-Dawley rats that were fed a high-fat diet for 8 wk and administrated 1, 5, or 10 mg/L of Myr. In this study, Myr reduced the weight gain, blood lipid levels, and the size and weight of the epididymal and perirenal adipose tissues.…”