Effects of Myosmine on Antioxidative Defence in Rat Liver

Simeonova, Rumyana; Vitcheva, Vessela; Gorneva, G.; Mitcheva, Mitka

doi:10.2478/10004-1254-63-2012-2190

Cited by 4 publications

(4 citation statements)

References 27 publications

(27 reference statements)

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“…The decreased levels of GSH in nicotine-treated rats indicate that GSH protects membrane lipids from oxidation by scavenging free radicals, passing from reduced to oxidized form (GSSG) (14,31,35 (8), thereby decreasing its activity as we observed in our study. Other studies (31,35) have also demonstrated the depletion of SOD and CAT in some organs of nicotine-treated rats.…”

Section: Gsh and Antioxidant Enzymessupporting

confidence: 56%

Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats

Paunović

Ognjanović

Matić

et al. 2016

Archives of Industrial Hygiene and Toxicology

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Nicotine is a potential inducer of oxidative stress, through which it can damage numerous biological molecules. The aim of our study was to investigate the prooxidative effects of nicotine and protective (additive or synergistic) effects of quercetin and vitamin C in the blood of experimental animals, to determine whether the combination of these antioxidants might be beneficial for clinical purposes. Wistar albino rats were receiving intraperitoneal nicotine injection (0.75 mg kg -1 per day) or saline (control group) or nicotine plus quercetin (40 mg kg -1 per day) and vitamin C (100 mg kg -1 per day) for three consecutive days. On day 4, we determined their blood lipid profile, liver enzymes, oxidative stress parameters, and antioxidative system parameters. Compared to untreated control, nicotine significantly increased total cholesterol, LDLcholesterol, triglycerides, liver enzymes (alanine transaminase, aspartate transaminase, and lactate dehydrogenase) and oxidative stress parameters (superoxide anion, hydrogen peroxide, and lipid peroxide) and decreased HDL-cholesterol, glutathione, and superoxide dismutase/catalase activity. Quercetin + vitamin C reversed these values significantly compared to the nicotine alone group. Our results confirm that nicotine has significant prooxidative effects that may disrupt the redox balance and show that the quercetin + vitamin C combination supports antioxidant defence mechanisms with strong haematoprotective activity against nicotine-induced toxicity. In practical terms, this means that a diet rich in vitamin C and quercetin could prevent nicotine-induced toxicity and could also be useful in the supportive care of people exposed to nicotine.

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Section: Gsh and Antioxidant Enzymessupporting

confidence: 56%

Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats

Paunović

Ognjanović

Matić

et al. 2016

Archives of Industrial Hygiene and Toxicology

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“…The regulation of NF-κB signaling directly affects expression of pro-inflammatory cytokines and inflammatory mediators involved in immune response. 33,34 Our findings showed that the SA concentration dependently suppressed LPS-induced IL-6 transcription (Fig. 2) on NF-κB activation, as evidenced by the decrease in NF-κB DNA-binding ability and reporter gene activity (Fig.…”

Section: Discussionmentioning

confidence: 69%

“…Previous studies have documented the antioxidant. 33 and hepatoprotective 7,10 activities of SA, but its immuno-modulatory effects have not been investigated. This study elucidated SA anti-inflammatory activity using LPSstimulated RAW 264.7 macrophages.…”

Section: Discussionmentioning

confidence: 99%

Saponarin from barley sprouts inhibits NF-κB and MAPK on LPS-induced RAW 264.7 cells

Seo

Park

et al. 2014

Food Funct.

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Saponarin (SA), a natural flavonoid, is known for its antioxidant and hepatoprotective activities. SA is the predominant compound (1142.7 ± 0.9 mg per 100 g) in barley sprouts, constituting 72% of the total polyphenol content. We investigated, for the first time, the effects of SA from barley sprouts on cellular anti-inflammatory responses. In lipopolysaccharide (LPS)-induced RAW 264.7 macrophages, SA suppressed the activation of NF-κB, as evidenced by the inhibition of NF-κB DNA binding, nuclear translocation, IκBα phosphorylation, and reporter gene expression, and it downregulated the expression of the pro-inflammatory mediator IL-6. Furthermore, SA reduced the transcription of NF-κB target molecules COX2 and FLIP inhibited the phosphorylation of mitogen-activated protein kinases ERK and p38. These results suggest that SA isolated from barley sprouts exerts anti-inflammatory effects in LPS-induced RAW 264.7 macrophages via inhibition of NF-κB, ERK and p38 signaling. Thus, SA may be a promising natural anti-inflammatory agent.

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“…In our previous experiments [57, 58] enhanced level of tissue lipid peroxides in nicotine treated rats (1 mg/kg i.p; 6,5 mg/kg p.o.) has been shown to be accompanied by a significant decrease in the levels of GSH, glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) and increased glutathione reductase (GR) activity in Wistar rat liver.…”

Section: Nicotinementioning

confidence: 99%

SomeIn Vitro/In VivoChemically-Induced Experimental Models of Liver Oxidative Stress in Rats

Simeonova

Kondeva-Burdina

Vitcheva

et al. 2014

BioMed Research International

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Oxidative stress is critically involved in a variety of diseases. Reactive oxygen species (ROS) are highly toxic molecules that are generated during the body's metabolic reactions and can react with and damage some cellular molecules such as lipids, proteins, or DNA. Liver is an important target of the oxidative stress because of its exposure to various prooxidant toxic compounds as well as of its metabolic function and ability to transform some xenobiotics to reactive toxic metabolites (as ROS). To investigate the processes of liver injuries and especially liver oxidative damages there are many experimental models, some of which we discuss further.

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Effects of Myosmine on Antioxidative Defence in Rat Liver

Cited by 4 publications

References 27 publications

Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats

Protective effects of quercetin and vitamin C against nicotine-induced toxicity in the blood of Wistar rats

Saponarin from barley sprouts inhibits NF-κB and MAPK on LPS-induced RAW 264.7 cells

SomeIn Vitro/In VivoChemically-Induced Experimental Models of Liver Oxidative Stress in Rats

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