Effects of Mycobacterium tuberculosis Rv1096 on mycobacterial cell division and modulation on macrophages

Deng, Guoying; Ji, Na; Shi, Xiaoxia; Zhang, Wenli; Qin, Yuanhua; Sha, Shanshan; Yang, Shufeng; Ma, Yufang

doi:10.1016/j.micpath.2020.103991

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…Evidences demonstrate that lncRNA expression levels are abnormal in PBMCs of patients with TB, implying that lncRNAs are associated with the pathology of TB (97)(98)(99)(100). LOC152742 levels in plasma of patients with ATB are higher than those in patients with previous episodes of TB and BCG-vaccinated individuals, suggesting that LOC152742 may be a potential biomarker for ATB discovery and treatment (92).…”

Section: The Roles Of Other Exosomal Ncrnas In M Tb Infectionmentioning

confidence: 99%

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

Wang

et al. 2023

Front. Immunol.

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Tuberculosis (TB) is a major infectious disease induced by Mycobacterium tuberculosis (M. tb) which causes the world’s dominant fatal bacterial contagious disease. Increasing studies have indicated that exosomes may be a novel option for the diagnosis and treatment of TB. Exosomes are nanovesicles (30-150 nm) containing lipids, proteins and non-coding RNAs (ncRNAs) released from various cells, and can transfer their cargos and communicate between cells. Furthermore, exosomal ncRNAs exhibit diagnosis potential in bacterial infections, including TB. Additionally, differential exosomal ncRNAs regulate the physiological and pathological functions of M. tb-infected cells and act as diagnostic markers for TB. This current review explored the potential biological roles and the diagnostic application prospects of exosomal ncRNAs, and included recent information on their pathogenic and therapeutic functions in TB.

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Section: The Roles Of Other Exosomal Ncrnas In M Tb Infectionmentioning

confidence: 99%

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

Wang

et al. 2023

Front. Immunol.

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“…It is reasonable to presume that the PMT-related virulence of M. tuberculosis might be associated with its mannoproteins because numerous mannoproteins have been confirmed to take part in mycobacterial pathogenesis [10,12,18]. In this context, we heterologously overexpressed Rv1002c in fast-growing Mycobacteria smegmatis (M. smegmatis) and performed mass spectrometry (MS) to analyze the effect of PMT on mannoproteins secretion in culture filtrate (CF).…”

mentioning

confidence: 99%

“…Mannoprotein PstS-1 (Rv0934) can bind to the mannose receptors on macrophages [10], and this binding favors bacterial intracellular survival [5]. Mannosylated protein Rv1096, identified as a novel peptidoglycan deacetylase [11], contributes to bacterial resistance to the bactericidal molecules within macrophages [12,13]. O-mannosylation of proteins is initiated by the protein O-mannosyltransferase (PMT), which catalyzes the transfer of mannose from lipid carriers to the serine or threonine residues of peptide chains [14].…”

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confidence: 99%

Protein O‐mannosyltransferase Rv1002c contributes to low cell permeability, biofilm formation in vitro, and mycobacterial survival in mice

Yang

Sui

Qin

et al. 2022

APMIS

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Mycobacterium tuberculosis (M. tuberculosis) Rv1002c encodes the protein O‐mannosyltransferase (PMT), which catalyzes the transfer of mannose to serine or threonine residues of proteins. We explored the function of PMT in vitro and in vivo. Rv1002c protein was heterogeneously overexpressed in nonpathogenic Mycobacterium smegmatis (named as MS_Rv1002c). A series of trials including mass spectrometry, transmission electron microscope, biofilm formation and antibiotics susceptibility were performed to explore the function of PMT on bacterial survival in vitro. Mouse experiments were carried out to evaluate the virulence of PMT in vivo. PMT decreased the cell envelope permeability and promoted microbial biofilm formation. PMT enhanced the mycobacterial survival in vivo and inhibited the release of pro‐inflammatory cytokines in serum. The function might be associated with an increased abundance of some mannoproteins in culture filtrate (CF). PMT is likely to be involved in mycobacterial survival both in vivo and in vitro due to increasing the mannoproteins abundance in CF.

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Mycobacterium tuberculosis Rv1096, facilitates mycobacterial survival by modulating the NF-κB/MAPK pathway as peptidoglycan N-deacetylase

Lü

Zhang

Fang

et al. 2020

Molecular Immunology

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Effects of Mycobacterium tuberculosis Rv1096 on mycobacterial cell division and modulation on macrophages

Cited by 3 publications

References 27 publications

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis

Protein O‐mannosyltransferase Rv1002c contributes to low cell permeability, biofilm formation in vitro, and mycobacterial survival in mice

Mycobacterium tuberculosis Rv1096, facilitates mycobacterial survival by modulating the NF-κB/MAPK pathway as peptidoglycan N-deacetylase

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