Effects of Multiwalled Carbon Nanotubes Received Orally during 6 Days on the Gastrointestinal Tract

Golokhvast, Kirill S.; Чайка, Владимир; Kuznetsov, L. V.; Elumeeva, Karina; Кусайкин, М. И.; Zakharenko, Alexander M.; Kiselev, N. N.; Паничев, А. М.; Reva, Galina; Usov, V. V.; Reva, Ivan; Yamamoto, Tatsuya; Gulkov, A. N.

doi:10.1007/s10517-013-2253-7

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…The length of carbon nanotubes was hundreds of times larger than the diameter and in water suspension; the particles could cohere into the spheres up to tens of micrometers in diameter. The toxicity of these NP samples was previously evaluated on mice [49], rats [50,51], human cell lines [52], and microalgae Heterosigma akashiwo [41].…”

Section: Nanoparticlesmentioning

confidence: 99%

Comparison of the Level and Mechanisms of Toxicity of Carbon Nanotubes, Carbon Nanofibers, and Silicon Nanotubes in Bioassay with Four Marine Microalgae

et al. 2020

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Nanoparticles (NPs) have various applications in medicine, cosmetics, optics, catalysis, environmental purification, and other areas nowadays. With an increasing annual production of NPs, the risks of their harmful influence to the environment and human health is rising. Currently, our knowledge about the mechanisms of interaction between NPs and living organisms is limited. Additionally, poor understanding of how physical and chemical characteristic and different conditions influence the toxicity of NPs restrict our attempts to develop the standards and regulations which might allow us to maintain safe living conditions. The marine species and their habitat environment are under continuous stress due to anthropogenic activities which result in the appearance of NPs in the aquatic environment. Our study aimed to evaluate and compare biochemical effects caused by the influence of different types of carbon nanotubes, carbon nanofibers, and silica nanotubes on four marine microalgae species. We evaluated the changes in growth-rate, esterase activity, membrane polarization, and size changes of microalgae cells using flow cytometry method. Our results demonstrated that toxic effects caused by the carbon nanotubes strongly correlated with the content of heavy metal impurities in the NPs. More hydrophobic carbon NPs with less ordered structure had a higher impact on the red microalgae P. purpureum because of higher adherence between the particles and mucous covering of the algae. Silica NPs caused significant inhibition of microalgae growth-rate predominantly produced by mechanical influence.

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Section: Nanoparticlesmentioning

confidence: 99%

Comparison of the Level and Mechanisms of Toxicity of Carbon Nanotubes, Carbon Nanofibers, and Silicon Nanotubes in Bioassay with Four Marine Microalgae

et al. 2020

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“…In vivo experiments on mouse models indicated the absence of a pronounced toxic effect under conditions of a short-term experiment. On contrary, nanotubes affected mouse gastrointestinal mucosa and induced a weak immune response based on CNT modification and functionalization [ 96 , 97 ]. Nevertheless, their good adsorption capacity is well utilized in solid phase extraction protocols mainly for zearalenone [ 98 , 99 , 100 ], trichothecenes [ 101 , 102 , 103 ], and aflatoxins [ 104 ].…”

Section: Nano Approaches For Mycotoxin Risk Eliminationmentioning

confidence: 99%

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

et al. 2018

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Mycotoxins are toxic secondary metabolites produced by certain filamentous fungi. The occurrence of mycotoxins in food and feed causes negative health impacts on both humans and animals. Clay binders, yeast cell walls, or antioxidant additives are the most widely used products for mycotoxin elimination to reduce their impact. Although conventional methods are constantly improving, current research trends are looking for innovative solutions. Nanotechnology approaches seem to be a promising, effective, and low-cost way to minimize the health effects of mycotoxins. This review aims to shed light on the critical knowledge gap in mycotoxin elimination by nanotechnology. There are three main strategies: mold inhibition, mycotoxin adsorption, and reducing the toxic effect via nanoparticles. One of the most promising methods is the use of carbon-based nanomaterials. Graphene has been shown to have a huge surface and high binding capacity for mycotoxins. Attention has also been drawn to polymeric nanoparticles; they could substitute adsorbents or enclose any substance, which would improve the health status of the organism. In light of these findings, this review gives new insights into possible future research that might overcome challenges associated with nanotechnology utilization for mycotoxin elimination from agricultural products.

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“…The length of carbon nanotubes was hundreds of times larger than diameter and in water suspension, the particles could cohere into the spheres up to tens of micrometers in diameter. The toxicity of these NP samples has been previously evaluated on mice [21], rats [22,23], human cell lines [24], and microalgae Heterosigma akashiwo [16].…”

Section: Nanoparticlesmentioning

confidence: 99%

Comparison of the Level and Mechanisms of Toxicity of Carbon Nanotubes, Carbon Nanofibers, and Silicon Nanotubes in Bioassay with Four Marine Microalgae

Pikula¹,

Чайка²,

Zakharenko³

et al. 2020

Preprint

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Nanoparticles (NPs) have various applications in medicine, cosmetics, optics, catalysis, environmental purification, and other areas nowadays. With an increasing annual production of NPs, the risks of their harmful influence to the environment and human health is rising. Currently, our knowledge about the mechanisms of interaction between NPs and living organisms is limited. Additionally, poor understanding of how physical and chemical characteristic and different conditions influence the toxicity of NPs restrict our attempts to develop the standards and regulations which might allow us to maintain the safe living conditions. The marine species and their habitat environment are under continuous stress due to anthropogenic activities which result in the appearance of NPs in the aquatic environment. Our study aimed to evaluate and compare biochemical effects caused by the influence of different types of carbon nanotubes, carbon nanofibers, and silica nanotubes on four marine microalgae species. We have evaluated the changes in growth-rate, esterase activity, membrane polarization, and size changes of microalgae cells using flow cytometry method. Our results demonstrated that toxic effects caused by the carbon nanotubes strongly correlated with the content of heavy metal impurities in the NPs. More hydrophobic carbon NPs with less ordered structure had a higher impact on the red microalgae P. purpureum because of higher adherence between the particles and mucous covering of the algae; silica NPs caused significant inhibition of microalgae growth-rate predominantly produced by mechanical influence.

show abstract

Effects of Multiwalled Carbon Nanotubes Received Orally during 6 Days on the Gastrointestinal Tract

Cited by 9 publications

References 6 publications

Comparison of the Level and Mechanisms of Toxicity of Carbon Nanotubes, Carbon Nanofibers, and Silicon Nanotubes in Bioassay with Four Marine Microalgae

Comparison of the Level and Mechanisms of Toxicity of Carbon Nanotubes, Carbon Nanofibers, and Silicon Nanotubes in Bioassay with Four Marine Microalgae

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

Comparison of the Level and Mechanisms of Toxicity of Carbon Nanotubes, Carbon Nanofibers, and Silicon Nanotubes in Bioassay with Four Marine Microalgae

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