Effects of Multivitamin/Mineral Supplementation on Trace Element Levels in Serum and Follicular Fluid of Women Undergoing in Vitro Fertilization (IVF)

Abstract

We investigated effects of multivitamin/mineral supplementation on element levels in serum and follicular fluid of women undergoing IVF. We used three groups in this study. The first group was used as an age-matched and nonpregnant control (n = 13). Group 2 (n = 30) constituted the IVF group and women in the third group who were undergoing IVF also received a multivitamin/mineral tablet daily for 45 days. Follicular fluid and serum selenium and zinc levels and follicular fluid copper levels were lower in IVF patients than in controls although follicular fluid aluminum and iron levels were higher in IVF patients than in controls. However, follicular fluid and serum aluminum, copper, zinc and selenium levels, and serum magnesium levels were higher in the multivitamin/mineral group than in the IVF group although follicular fluid iron levels were lower in the multivitamin/mineral group than in the IVF group. In conclusion, we observed that copper, zinc, and selenium in serum and follicular fluid decreased in women undergoing IVF. Multivitamin/mineral supplementation in serum and follicular fluid of women undergoing IVF normalized the trace element levels.

Determination of oxidative stress balance in follicular fluid

“…They suggested that these molecules may be effective in quenching excessive generation of free radicals, but they do not seem to play a contributory role in achieving successful pregnancy following IVF. This is an important observation in view of the fact that several groups have the opinion that antioxidants, mineral and vitamin supplementation may considerably improve the IVF success rate [42,43]. However, our study conflicts with the results of some other studies [8,36,44], which observed that lower levels of antioxidants predict decreased fertilization potential.…”

Effects of Erythropoietin on the Serum and Liver Tissue Levels of Copper and Zinc in Rats with Obstructive Jaundice / Efekti Eritropoetina Na Nivoe Bakra I Cinka U Serumu I Tkivima Jetre Kod Pacova Sa Opstruktivnom Žuticom

“…The finding of increased le vels of Cu in OJ rats in our study was supported by the results of Devipriya et al (13). Excess cumulation of Cu in rats triggers oxidative damage of the kidney and liver tissue DNAs and ultimately contributes to many degenerative disorders (19). In this study we observed that OJ group had higher levels of serum and liver Cu, respectively (p<0.001 and p=0.003), than other groups.…”

Effects of Shock Waves on Oxidative Stress, Antioxidant Enzyme and Element Levels in Kidney of Rats

“…Cu is an essential element that plays a role in the production of hemoglobin, myelin, collagen, and melanin [24]. Cu deficiency affects various physiological functions that may be important in immunological defense to pathogenic challenge [25,26]. Cu has also function as cofactor of SOD and CAT in antioxidant redox system [26,27].…”