Effects of multiple sclerosis on respiratory functions

Mutluay, Fatma; Gürses, Hülya Nilgün; Saıp, Sabahattin

doi:10.1191/0269215505cr782oa

Cited by 60 publications

(62 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3][4] Functional deficits and impairments, such as muscle weakness, fatigue, and impaired ventilation, have long been recognized as major causes of morbidity and mortality in individuals with advanced MS. 5,6 Walking and stair climbing are critically important to maintaining community-level functioning and independence. 7 Tests of lower-extremity function are known to be strong predictors for risk of disability and hospitalization in older community-dwelling persons; [8][9][10][11] however, there are limited data on physical performance function in community-dwelling individuals with MS.…”

Section: Introductionmentioning

confidence: 99%

Six-Minute Walk Test for Persons with Mild or Moderate Disability from Multiple Sclerosis: Performance and Explanatory Factors

Wetzel¹,

Fry²,

Pfalzer³

2011

Physiotherapy Canada

View full text Add to dashboard Cite

Purpose: The primary purpose of this study was to determine the extent to which health factors, functional measures, and pulmonary impairment explain performance on 6-Minute Walk Test (6MWT) distance in ambulatory persons with multiple sclerosis (MS). Another purpose was to determine the effect of disability and age on 6MWT performance and explanatory factors. Methods: A cross-sectional study design was used to evaluate factors that explain performance on the 6MWT in 64 community-dwelling persons with MSrelated disability (Expanded Disability Status Scale [EDSS] 3.8 e 1.6). Of the 64 participants, 43 (67.2%) exhibited mild disability (EDSS <4.0) and 21 (32.8%) had moderate disability Results: EDSS, ABC, FST, SST, BAL, MVV, MIP, and MEP were significantly associated with 6MWT distance after adjusting for age. Multiple step-wise linear regression analysis revealed that ABC, FST, and BAL were significant and independent explanatory factors of 6MWT distance. ABC and FST explained 75% of the variance in 6MWT performance (R 2 ¼ 0.75). Curvilinear regression analysis revealed that the FST is the most significant explanatory factor for 6MWT distance, explaining 79% of the variance (R 2 ¼ 0.79). Conclusions: 6MWT performance in persons with MS was explained by balance confidence (ABC) and stair-climbing ability (FST). The ABC and FST may be practical clinical measures for explaining walking ability and determining risk for disablement in persons with MS. RÉ SUMÉObjectif : L'objectif principal de cette é tude é tait de dé terminer jusqu'à quel point les facteurs de santé , les mesures fonctionnelles et les incapacité s pulmonaires influent sur les ré sultats en terme de distance au test de marche de 6 minutes (6MWT) chez les personnes qui souffrent de sclé rose en plaques (SP) et qui sont encore ambulatoires. Un autre objectif consistait à é valuer l'effet de l'incapacité et de l'â ge sur les ré sultats au 6MWT et sur les facteurs explicatifs. Mé thode : Une é tude transversale a é té utilisé e pour é valuer les facteurs expliquant les ré sultats au 6MWT chez 64 personnes avec SP qui vivent dans des habitations communautaires, avec incapacité s lié es à leur maladie (é chelle d'incapacité EDSS 3,8 e 1,6). Au total, 43 sujets (67,2 %) dé montraient une incapacité lé gè re (EDSS < 4,0) et 21 (32,8 %) avaient une incapacité modé ré e (EDSS 4,0-6,5). The authors have no conflicts of interest to declare.We thank the following individuals for their assistance with the study: Susan Kushner, PT, MS; Anang Chokshi, DPT; Shelley Wagner, DPT; Emily Jackson, DPT; Julie Vasieck, DPT; Shawna Pringle, DPT; and Angela English, DPT. Jane L. Wetzel, PT, PhD: Associate Professor, Department of Physical Therapy, Youngstown State University, Youngstown, Ohio (current); Duquesne University, Pittsburgh, Pennsylvania (at time of study). Ré sultats : Les tests EDSS, ABC, FST, SST, BAL, MVV, MIP et MEP é taient associé s de maniè re significative à la distance parcourue lors du 6MWT, aprè s ajustement de l'â ge. Une analyse de ré gressio...

show abstract

Section: Introductionmentioning

confidence: 99%

Six-Minute Walk Test for Persons with Mild or Moderate Disability from Multiple Sclerosis: Performance and Explanatory Factors

Wetzel¹,

Fry²,

Pfalzer³

2011

Physiotherapy Canada

View full text Add to dashboard Cite

show abstract

“…Una musculatura sobre la que se debe prestar especial atención es la musculatura respiratoria, debido a que esta enfermedad se acompaña de una debilidad importante de dicha musculatura, pudiendo ser un mecanismo adicional en el aumento de la discapacidad característica de la enfermedad (177). De este modo, un entrenamiento de 3 sesiones semanales de 30 minutos dirigido al desarrollo de los músculos inspiratorios y espiratorios ha demostrado ser efectivo para mejorar tanto la resistencia a la fatiga de dichos músculos como la puntuación en un cuestionario SF-36-Health Survey, que reflejaría una mejor autopercepción de salud y un menor esfuerzo a la hora de realizar actividades de la vida diaria (178).…”

Section: Entrenamiento Contra Resistencias Y Esclerosis Múltipleunclassified

Efectos del entrenamiento contra resistencias o resistance training en diversas patologías

2016

View full text Add to dashboard Cite

Palabras clave:Actividad física. Salud. Ejercicio. Enfermedad cardiovascular. Key words:Physical activity. Health. Exercise. Cardiovascular disease. AbstractStrength performance directly affects the health and fi tness ability, so resistance training (RT) is included in those exercise programs aimed at improving the health and quality of life. Because many diseases present with altered muscle mass and functionality as the RT is the main form of exercise aimed at improving muscle function, the purpose of this literature review was to expose the current evidence on the adaptations of RT, and their possible application in diseases such as obesity, diabetes, dyslipidemia, hypertension, cancer, Parkinson's, multiple sclerosis or fi bromyalgia. The RT in these diseases can increase levels of muscle mass, decreasing body fat levels, levels of fatty acids in blood and blood glucose by increasing insulin sensitivity and decreasing levels of infl ammatory cytokines. The RT also improves cardiac output and endothelial function, regulating blood pressure and increasing oxygen consumption. Muscle strength gains improve the functionality and quality of life, especially in people with severe neuromuscular involvement as they could be those suffering from multiple sclerosis, fi bromyalgia and Parkinson's. Therefore, the RT should be incorporated as part of treatment in people who have certain types of diseases. ResumenLa fuerza infl uye directamente en el estado de salud y en la capacidad de fi tness, motivo por el que el entrenamiento contra resistencias o resistance training (RT) se incluye dentro de aquellos programas de ejercicio encaminados a mejorar la salud y calidad de vida. Debido a que muchas enfermedades cursan con alteración de la masa y funcionalidad muscular y a que el RT es la principal modalidad de ejercicio encaminada a mejorar la función muscular, el objetivo de la presente revisión bibliográfi ca ha sido exponer las evidencias actuales sobre las adaptaciones del RT, así como su posible aplicación en patologías como la obesidad, diabetes, dislipemia, hipertensión, cáncer, Parkinson, esclerosis múltiple o fi bromialgia. El RT en estas enfermedades puede aumentar los niveles de masa muscular, disminuyendo los niveles de masa grasa, los niveles de ácidos grasos en sangre y la glucemia, incrementando la sensibilidad a la insulina, y disminuyendo los niveles de citokinas infl amatorias. El RT, además, mejora el gasto cardiaco y la funcionalidad endotelial, regulando la tensión arterial e incrementando el consumo de oxígeno. Las ganancias de fuerza muscular mejoran la funcionalidad y la calidad de vida, especialmente en población con una afectación neuromuscular grave, como pudieran ser los enfermos de esclerosis múltiple, fi bromialgia o Parkinson. Por ello, el RT debe ser incorporado como parte del tratamiento en las personas que presentan determinado tipo de patologías.

show abstract

“…Pulmonary complications and infections are another major cause of morbidity in MS, and their attributable mortality is as much as two-fold higher than in the general population [2]. Pulmonary manifestations of MS consist primarily of respiratory muscle weakness that leads to impaired ventilation and poor cough [1, [3][4][5][6]. Several reports have suggested that the expiratory muscles are preferentially involved [1,3].…”

mentioning

confidence: 99%

“…Children are not usually included in global surveys of MDR-TB incidence and prevalence [2] due to the diagnostic challenges of paucibacillary TB [3]. Data on the burden of MDR-TB in children are, therefore, lacking globally [1, 4,5] and no published data from the UK exist. The current World Health Organization (WHO) [6] and National Institute for Clinical Excellence (NICE) [7] TB guidelines for the management of MDR-TB do not explicitly address paediatric disease.…”

mentioning

confidence: 99%

“…The diagnosis of respiratory muscle dysfunction is often made clinically with the aid of standard PFTs. Several studies have shown a consistent decrease in maximal muscle forces in ambulatory asymptomatic patients without additional pulmonary functional abnormalities [1, 4,5]. There is a correlation between more severe reductions in muscle forces and disease severity [1].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Disturbance of respiratory muscle control in a patient with early-stage multiple sclerosis

Mustafa

Loring²,

Riskind

et al. 2013

Eur Respir J

View full text Add to dashboard Cite

Respiratory dysfunction from multiple sclerosis (MS) is most commonly of insidious onset and related to progressive respiratory muscle weakness [1]. Disorders of respiratory muscle coordination are poorly recognised and challenging to diagnose. We present a case of a patient with MS and no clear muscle weakness whose dyspnoea was associated with a disorder of respiratory muscle control. The potential utility of oesophageal manometry for diagnosis of unexplained dyspnoea is highlighted.A 54-year-old female with relapsing-remitting MS presented with 2 weeks of dyspnoea and orthopnoea. She was ambulatory with a low extended disability score of 1.5. 6 months earlier she started cyclophosphamide for disease progression recognised by magnetic resonance imaging (MRI). A week after her last infusion she developed severe dyspnoea and orthopnoea. She had no other symptoms. Her vital signs were normal. Her laboratory tests and arterial blood gas were unremarkable. Chest computed tomography showed no pulmonary parenchymal disease. Echocardiography was unremarkable. Pulmonary function testing (PFTs) demonstrated severe restriction, with a 14% lower vital capacity in the supine position.

show abstract

Effects of multiple sclerosis on respiratory functions

Abstract: Multiple sclerosis clearly impairs respiratory functions; maximal mouth pressures are more severely reduced. This impairment increases with multiple sclerosis-induced disability level but is found to be independent from duration of disease.

Cited by 60 publications

References 16 publications

Six-Minute Walk Test for Persons with Mild or Moderate Disability from Multiple Sclerosis: Performance and Explanatory Factors

Six-Minute Walk Test for Persons with Mild or Moderate Disability from Multiple Sclerosis: Performance and Explanatory Factors

Efectos del entrenamiento contra resistencias o resistance training en diversas patologías

Disturbance of respiratory muscle control in a patient with early-stage multiple sclerosis

Contact Info

Product

Resources

About