Effects of multicarbohydrase and butyrate glycerides on productive performance, nutrient digestibility, gut morphology, and ileal microbiota in late-phase laying hens fed corn- or wheat-based diets

Fermented calcium butyrate supplementation in post-peak laying hens improved ovarian function and tibia quality through the “gut-bone” axis

“…It is known that the intestine plays a crucial role in preventing the passage of pathogens, antigens, and bacterial toxins into the systemic circulation. The relationships between intestinal integrity in laying performance and egg quality have been established ( Abbasi et al., 2021 ; Gan et al., 2020 ; Zhang et al., 2022c ). It was reported that weakened intestinal mucosal barrier function probably induces an increase in inflammation, inhibits ovarian follicular growth, and causes a decrease in laying performance ( Nii et al., 2020 ).…”

“…Although direct evidence cannot be found in terms of the relationship among the gut microbiota, intestinal barrier, and ovarian health, the improved production and egg quality due to enhanced intestinal morphology, integrity, and/or microbial composition in laying hens ( Abbasi et al., 2021 ; Gan et al., 2020 ; Zhang et al., 2022c ) could be attributed to the reduction in the inflammatory response of ovary. Indeed, in addition to its function in the absorption and metabolization of nutrients, the intestine also plays a crucial role in the immune system as a physical barrier by preventing the passage of pathogens, antigens, and bacterial toxins into the systemic circulation and secreting immunological molecules.…”

Dietary supplementation with Clostridium butyricum and its ferment substance improves the egg quality and ovarian function in laying hens from 50 to 58 weeks of age

“…The roles of intestinal integrity in laying performance and egg quality have been established (Abbasi Arabshahi et al, 2021; Gan et al, 2020; Zhang, Zhang, et al, 2022), which could prevent the passage of pathogens, antigens, and bacterial toxins into the systemic circulation. The weakened intestinal barrier probably induces an increase in the inflammatory reaction, resulting in reduced ovarian follicular growth and laying performance (Nii et al, 2020).…”

“…The decrease in egg quality of laying hens as extending the egg production period has been noticed in practice (Tumová & Gous, 2012), which is closely linked to sustainedly damaged intestinal barriers and reproductive organs because of age and the high intensity of production (Braw‐Tal et al, 2004; Gu et al, 2021; Wang et al, 2020). To mitigate these adverse effects, some strategies, including organic acids butyrate (Abbasi Arabshahi et al, 2021; Kazempour & Jahanian, 2017; Zhang, Zhang, et al, 2022), vitamins (Gan et al, 2020), probiotics such as Clostridium butyricum ( C. butyricum ) (Wang et al, 2021), and essential oils (Wang et al, 2022; Zhang, Wang, et al, 2022), have been widely sought out in the laying chicken industry. Of note, C. butyricum , a butyrate‐producing bacteria, has been used as a probiotic in clinical and veterinary medicine for decades (Ariyoshi et al, 2022).…”

Butyrate ameliorates maternal high-fat diet-induced fetal liver cellular apoptosis

“…Previous reports have shown that HFD led to reduced small intestinal villus length in a rodent model [ 27 , 28 ]. Butyrate supplementation increased jejunal villus height and villus surface area [ 29 ]. The gut liver axis activation is changed after HFD.…”