Effects of Mu- and kappa-opioid receptor agonists on urinary output in mice

Rathbun, Robert C.; Kattau, Richard W.; Leander, J. David

doi:10.1016/0091-3057(83)90094-1

Cited by 13 publications

(5 citation statements)

References 6 publications

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“…Not all studies report a decrease in urine output with mu‐opioid agonists. Rathburn et al. (1983) observed an increase in urine output in mice during morphine administration and little to no effect on urine output during fentanyl administration.…”

Section: Discussionmentioning

confidence: 87%

Effects of morphine and fentanyl constant rate infusion on urine output in healthy and traumatized dogs

Anderson

Day

2008

Veterinary Anaesthesia and Analgesia

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Section: Discussionmentioning

confidence: 87%

Effects of morphine and fentanyl constant rate infusion on urine output in healthy and traumatized dogs

Anderson

Day

2008

Veterinary Anaesthesia and Analgesia

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“…1985;Vaupel et al 1990;Kapusta et af. 1993) and mice (Rathbun et al 1983). Thus, while mu-opioids characteristically produce an antidiuresis in humans (Fujimoto 1971) and other animal species, they are clearly capable of inducing diuresis under certain circumstances.…”

Section: Renal Responses Produced By Mu Opioidsmentioning

confidence: 99%

Opioid Mechanisms Controlling Renal Function

Kapusta

1995

Clin Exp Pharma Physio

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1. Over the past 50 years considerable evidence has been reported suggesting that endogenous opioids participate in the control of renal function. 2. Exogenous administration of opioids produces profound changes in the renal excretion of water and sodium. 3. Opioids produce changes in urine output and urine sodium excretion by multiple integrated neural and hormonal mechanisms within the periphery, central nervous system and kidneys. 4. Although opioid antagonist administration does not consistently reveal an action of endogenous opioid systems on renal function, this may result from the quiescent nature of the endogenous opioid system under basal conditions. 5. Manipulations that activate endogenous opioid systems have begun to reveal important, previously unrecognized mechanisms that control kidney function and can enhance renal tubular sodium reabsorption in normal and potentially pathological states.

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“…Both central and peripheral administration of selective KOR agonists as well as the endogenous ligand, dynorphin, leads to an increase in urinary flow rate also known as a diuresis, in rats [19-23], mice [24], dogs [25], and humans [26,27]: Slizgi and Ludens first reported a diuretic response to subcutaneous (S.Q.) administration of the partial KOR agonist and benzomorphan analogue, EKC to conscious rats [28].…”

Section: Renal Effects Of Korsmentioning

confidence: 99%

Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny

Smith

2011

Pharmaceuticals

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This review focuses on the physiological roles for kappa opioid receptors (KORs) in adult animals and humans, as well as in the developing newborn animal. Our recent findings have provided new information that under physiological conditions in conscious newborn animals, activation of KORs with the selective agonist, U-50488H, results in an aquaresis, as previously observed in adult animals and humans. In addition, we have shown in conscious lambs that KORs modulate systemic and renal haemodynamics as well as the arterial baroreflex control of heart rate, providing a previously unidentified role for KORs.

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Effects of Mu- and kappa-opioid receptor agonists on urinary output in mice

Cited by 13 publications

References 6 publications

Effects of morphine and fentanyl constant rate infusion on urine output in healthy and traumatized dogs

Effects of morphine and fentanyl constant rate infusion on urine output in healthy and traumatized dogs

Opioid Mechanisms Controlling Renal Function

Cardiorenal Effects of Kappa Opioid Peptides During Ontogeny

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