Effects of MRI contrast agents (Omniscan™) on vestibular end organs

Abstract

Application of 4-16-fold diluted Omniscan caused morphological damage of isolated vestibular hair cells and decreased action potentials of the posterior semicircular canal. After application of 32-fold diluted Omniscan, no apparent changes were noted even after 20 min, both morphologically and physiologically.

Hearing function after intratympanic application of gadolinium‐based contrast agent: A long‐term evaluation

“…Animal studies from Tanaka et al showed morphological changes such as shape changing, hair cell impairment, and cell shrinkage in vestibular end organs of bullfrogs after application of fourfold diluted GBCA. With the eightfold and sixteenfold dilution, the morphological changes were less frequent.…”