Effects of Moving Training on Histology and Biomarkers Levels of Articular Cartilage

Chang, Qi; Huang, Chang-lin

doi:10.1016/j.jss.2006.03.011

Cited by 28 publications

(33 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1), indicating that cartilage and bone metabolism (type II collagen degradation and bone resorption) is increased in soccer players as reported in other sports players and experimental animal models with extremes of skeletal exercise (1)(2)(3)(4)(5). Moreover, CPII level was substantially increased in soccer players compared with that in controls (Fig.…”

Section: Discussionsupporting

confidence: 65%

“…The disease process of OA is related to the degradation and functional loss of joint cartilage. Importantly, studies with experimental OA models have shown that the early changes in the metabolic and chemical properties of cartilage matrix can be detected before the appearance of radiological changes (2). Thus, various molecular markers have been developed as indicators of cartilage and bone metabolism in patients with joint and bone disorders (8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, various molecular markers have been developed as indicators of cartilage and bone metabolism in patients with joint and bone disorders (8)(9)(10)(11). In this context, it is interesting to note that sports-related mechanical loading on the joints affects the turnover rate of cartilage as well as bone in humans and experimental animal models, which can be detected by systemic biomarker assays (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players

Yoshimura

Sakamoto²,

Tsuruta³

et al. 2009

Int J Mol Med

View full text Add to dashboard Cite

Abstract. In the present study, to investigate the effect of glucosamine, a component of glycosaminoglycans with a chondroprotective action, on articular cartilage in athletes, we looked at soccer players, who expose their joints to excessive motion and loading, and compared the levels of biomarkers for type II collagen degradation (CTX-II) and type II collagen synthesis (CPII) between soccer players and non-athlete controls, and in soccer players before and after glucosamine-administration. CTX-II (P<0.01) and CPII (P=0.08) levels were substantially elevated in soccer players compared with those in controls, indicating that cartilage metabolism (type II collagen degradation and synthesis) is increased in soccer players. Of note, glucosamine administration (1.5 g and 3 g/day for 3 months) significantly decreased the CTX-II level (P<0.05); however, the effect disappeared after withdrawal of administration. In contrast, glucosamine administration did not essentially affect the increased level of CPII. Furthermore, cartilage damage was evaluated by using the ratio of type II collagen breakdown to synthesis (CTX-II/CPII). The ratio in soccer players was significantly higher than that in controls (P<0.05), suggesting that type II collagen degradation is relatively enhanced compared with type II collagen synthesis in soccer players than in control students. Of importance, the ratio was reduced by glucosamine administration but returned to the pre-administration level after withdrawal of administration. Together these observations suggest that glucosamine is expected to exert a chondroprotective action in athletes (soccer players) by preventing type II collagen degradation but maintaining type II collagen synthesis, although the effect is transient and disappears after withdrawal of administration.

show abstract

Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players

Yoshimura

Sakamoto²,

Tsuruta³

et al. 2009

Int J Mol Med

View full text Add to dashboard Cite

show abstract

“…The disease process of osteoarthritis is related to the degradation and functional loss of articular cartilage. Importantly, the early changes in the metabolic and biochemical properties of cartilage matrix can be detected before the appearance of morphological changes of cartilage 2) . Thus, various biomarkers have been developed as indicators of cartilage and bone metabolism in subjects with joint and bone disorders 5) .…”

Section: Introductionmentioning

confidence: 99%

Joint Health of Athletes and the Chondroprotective Action of Glucosamine

Nagaoka

2017

Juntendo Medical Journal

View full text Add to dashboard Cite

In endurance athletes with intense joint loading, cartilage metabolism (degradation of type II collagen) is enhanced compared with non-athletes and non-endurance athletes. Recently, we have revealed that glucosamine, a functional food, exerts a protective action on cartilage metabolism in not only osteoarthritis patients but also endurance athletes (such as soccer players and rugby players) by suppressing the degradation of type II collagen.In this review, to demonstrate these findings, the following topics will be explained: 1. Biomarkers for cartilage metabolism; 2. Evaluation of osteoarthritis and endurance sports by using biomarkers of cartilage metabolism; 3. Chondroprotective action of glucosamine on osteoarthritis patients and endurance sports athletes; 4. Glucosamine as a"Food with Function Claim" .

show abstract

“…In osteoarthritis, knee joints are particularly impaired, because they are weight-bearing joints. Previous studies in experimental osteoarthritis models have indicated that changes in the chemical and metabolic properties of cartilage matrix are detectable at early stages of arthritis [4].…”

mentioning

confidence: 99%

Evaluation of the effect of N-acetyl-glucosamine administration on biomarkers for cartilage metabolism in healthy individuals: a randomized double-blind placebo-controlled clinical study

Tsuji¹,

Mitsuhiko²,

Suzuki³

et al. 2017

FFHD

View full text Add to dashboard Cite

Effects of Moving Training on Histology and Biomarkers Levels of Articular Cartilage

Cited by 28 publications

References 51 publications

Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players

Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players

Joint Health of Athletes and the Chondroprotective Action of Glucosamine

Evaluation of the effect of N-acetyl-glucosamine administration on biomarkers for cartilage metabolism in healthy individuals: a randomized double-blind placebo-controlled clinical study

Contact Info

Product

Resources

About