Effects of Mothers' Autoimmune Disease During Pregnancy on Learning Disabilities and Hand Preference in Their Children

Ross, Gail; Sammaritano, Lisa R.; Nass, Ruth; Lockshin, Michael D.

doi:10.1001/archpedi.157.4.397

Cited by 113 publications

(94 citation statements)

References 22 publications

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“…Evaluation of this female patient with the Griffith Mental Development Scales showed normal neurodevelopmental functioning for age at 29 months [22] . Our findings contrast with the data reported by Ross et al [23] who suggested that male offspring of mothers with SLE and SS-A/Ro autoantibodies, in spite of having high average IQs, have a higher incidence of learning disabilities, even in the absence of HB. We did not perform full-scale IQ testing or determine academic achievement scores which is a limitation of this study.…”

Section: Discussioncontrasting

confidence: 99%

Neurological Outcome in Isolated Congenital Heart Block and Hydrops Fetalis

Breur¹,

Gooskens²,

Kapusta³

et al. 2007

Fetal Diagn Ther

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Objective: Isolated fetal heart block (HB), a condition associated with fetal hydrops, carries a high mortality rate and may result in neurodevelopmental sequelae. To the best of our knowledge, no data exist regarding the long-term outcome of such hydropic fetuses. We reviewed our experience with this condition to determine the neurodevelopmental outcome of prenatally diagnosed cases with isolated HB complicated by hydrops fetalis. Methods: Neurodevelopmental assessment of 5 children presented prenatally with isolated HB associated with hydrops fetalis. Results: During the last 18 years, 10 cases were detected prenatally with isolated HB and hydrops fetalis. 3 of the 10 fetuses died in utero, and 2 died postnatally, due to a dilated cardiomyopathy, at the age of 9 months and 4 years, respectively. Neurodevelopmental studies done on the 5 remaining children were normal. Conclusion: Long-term neurodevelopmental assessments of 5 surviving cases presented prenatally with isolated HB and hydrops fetalis are reassuring.

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Section: Discussioncontrasting

confidence: 99%

Neurological Outcome in Isolated Congenital Heart Block and Hydrops Fetalis

Breur¹,

Gooskens²,

Kapusta³

et al. 2007

Fetal Diagn Ther

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“…Once detected, complete heart block cannot be reversed, but there are reports of second-degree heart block reverting to first-degree heart block after dexamethasone therapy [26]. Some studies have suggested that exposure to anti-Ro is associated with a higher prevalence of developmental dyslexia [27].…”

Section: Discussionmentioning

confidence: 99%

The correlation of pregnancy complications with C3/C4 levels, anti-dsDNA titers, and autoimmune target testing in gravidas with systemic lupus erythematosus

Kim¹,

Kim

Kang

et al. 2011

Korean J Obstet Gynecol

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ObjectiveThe purpose of this study was to evaluate the correlation between complement (C3 and C4) levels, anti-dsDNA titers, autoimmune target test (AITT), and pregnancy complications. MethodsNinety-three pregnancies with systemic lupus erythematosus (SLE) were analyzed retrospectively. We evaluated the course of the pregnancy and outcome, pregnancy complications, progression of SLE, maternal complications of SLE, drugs taken before and after pregnancy, neonatal outcomes, and C3/C4 levels, anti-dsDNA titers, and AITT results. SPSS ver. 14.0 was used for statistical analysis. The average and standard deviation are shown. Chi-square test and Pearson correlation test were used for statistical analysis. The significance level was set at 0.05. ResultsThe C3 level was associated with maternal leukopenia, elevated serum C-reactive protein (CRP) elevation, hematuria, hypertension, and preterm premature rupture of membranes. The C4 level was associated with maternal proteinuria, hematuria, hematologic disease, and admission to the neonatal intensive care unit. The anti-dsDNA titer was associated with elevated maternal serum CRP, oligohydramnios, and neonatal anti-Sjögren's syndrome B (La) antibody. The AITT result was related to elevated erythrocyte sedimentation rate, and 1 and 5 minute Apgar scores. ConclusionOur result show that adding the AITT to conventional C3/C4 and anti-dsDNA testing in gravidas with SLE might help antenatal care.

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“…Follow-up of children born to women with lupus has shown an increase in learning disabilities and non-right-handedness in male offspring, as well as increased anxiety and depression. 83,84 Clearly this needs to be studied further, and intervention programs need to be developed to help families cope with the issue of caring for their children when the mother has a chronic illness.…”

Section: Suggested Guidelinesmentioning

confidence: 99%

Lupus and Pregnancy: Complex Yet Manageable

Dhar

Sokol²

2006

Clinical Medicine & Research

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Systemic lupus erythematosus is a chronic multi-system autoimmune disease that occurs predominantly in women of childbearing age. The risk of complications and adverse fetal outcomes in pregnant women with lupus is high. Moreover, pregnancy can cause flares of lupus disease activity necessitating maternal immunosuppressive intervention. Interestingly, many potential complications of pregnancy present as symptoms of lupus making diagnosis and treatment a challenge.Advancing technology and better understanding of the maternal-fetal dyad in lupus have improved outcomes in lupus pregnancies over the last 40 years. This article will briefly review the important issues in pregnancies complicated by lupus and provide a general guideline to physicians for monitoring and treatment.

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Effects of Mothers' Autoimmune Disease During Pregnancy on Learning Disabilities and Hand Preference in Their Children

Cited by 113 publications

References 22 publications

Neurological Outcome in Isolated Congenital Heart Block and Hydrops Fetalis

Neurological Outcome in Isolated Congenital Heart Block and Hydrops Fetalis

The correlation of pregnancy complications with C3/C4 levels, anti-dsDNA titers, and autoimmune target testing in gravidas with systemic lupus erythematosus

Lupus and Pregnancy: Complex Yet Manageable

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