Effects of morphine withdrawal syndrome on endo-oligopeptidase (EC 3.4.22.19) activity

Paik, Seung Hoon; Camarão, G.C.; Bauer, Jarbas Arruda; Leite, Paulo Eduardo Pereira; Oliveira, Elisabeth Spinelli de; Camargo, Antônio Carlos Martins de; Farges, Roseli

doi:10.1016/0014-2999(94)90763-3

Cited by 8 publications

(2 citation statements)

References 33 publications

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“…This finding appears to be consistent with the results from Bauer's study [79] according to which chronic opioid dependence exerts an adverse effect on neural transmission within the primary visual area of the brain. Furthermore, the aforementioned study of Paik et al [62] provides comparable results, indicating the involvement of the occipital region in the reward system. In this respect, it is worth mentioning that OCD patients exhibited an increased P300 latency, located at the central prefrontal area.…”

Section: Discussionsupporting

confidence: 66%

“…In this context, it seems noteworthy that neuropharmacological studies focusing on long-lasting changes in dendritic branching after repeated injection of morphine [60,61], the measurement of end-oligopeptide (an enzyme capable of generating encephaline from encephaline-containing peptides) [62], and functional neuroimaging methods assessing cerebral blood flow [63,64] also suggest a linkage between the right prefrontal area and behavioral effects of opiate.…”

Section: Discussionmentioning

confidence: 99%

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Do Obsessive-Compulsive Patients and Abstinent Heroin Addicts Share a Common Psychophysiological Mechanism?

et al. 2003

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Background/Aim: Working memory (WM) and attentional deficits have been implicated in the pathophysiology of both obsessive-compulsive disorder (OCD) and opioid addiction. The P300 component of event-related potentials (ERPs) is considered as an index of on-line updating of WM and/or attentional operations involved in this function. The present study aimed at comparing the P300 elicited during a WM test in patients with prolonged heroin abstinence, those with OCD and healthy controls, in order to demonstrate possibly common underlying psychophysiological mechanisms. Methods: The P300 component was evaluated during the anticipatory period of a WM test in 20 patients characterized by a past history of opioid dependence (6 months abstinence), in 18 OCD patients, and 20 healthy subjects matched for age, sex and educational level. Results: The two patient groups showed a considerable reduction of the P300 amplitudes, located at the right frontal area as compared with healthy controls. The abstinent heroin addicts exhibited a significantly lower P300 amplitude at central frontal areas and a significantly higher P300 amplitude at the left occipital region relative to the other two groups. Furthermore, the abstinent group showed a notable delay of P300 latency relative to controls and OCD patients at the right occipital region. Moreover, the OCD patients manifested a significant prolongation of P300 located at the central prefrontal area, relative to addicts and healthy controls. Conclusions: These findings point to considerable WM and/or attentional deficits in the long-term abstinent syndrome of heroin misuse and OCD associated with distributed and prefrontal cortical circuits, respectively. Furthermore, the present findings suggest that both OCD and long-term abstinent heroin addicts may share a common impairment of WM and/or attention involving or affecting the right prefrontal areas.

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Section: Discussionsupporting

confidence: 66%