Effects of Moringa oleifera leaf extracts and its bioactive compound gallic acid on reducing toxicities of heavy metals and metalloid in Saccharomyces cerevisiae

Kerdsomboon, Kittikhun; Chumsawat, Wisuta; Auesukaree, Choowong

doi:10.1016/j.chemosphere.2020.128659

Cited by 29 publications

(17 citation statements)

References 51 publications

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“…These functional groups are good metal sequesters from an aqueous solution (Bennett et al 2003). Additionally, Kerdsomboon et al (2021) reported that the hydroxyl and carboxyl groups of gallic acid found in AMOLE play a critical role in chelating As(III) and potentially bind with cadmium and other heavy metals as well. We hypothesized that AMOLE contents could effectively act as Cd chelators preventing Cd ions from interacting with seeds, resulting in reduced toxicity on rice seed germination.…”

Section: Discussionmentioning

confidence: 99%

“…Aqueous M. oleifera leaf extract (AMOLE) was prepared according to Kerdsomboon et al (2021) with some modi cations. Speci cally, 4.5 g of M. oleifera leaf powder was mixed with 30 mL distilled water in a 50 ml test tube.…”

Section: Preparation Of Aqueous M Oleifera Leaf Extract (Amole)mentioning

confidence: 99%

“…(2021) reported that aqueous Moringa oleifera leaf extract (AMOLE) reduced intracellular reactive oxygen species (ROS) levels in yeast cells grown in the presence of As(III), Cd, Ni, and Pb. It was shown in that study that gallic acid, a component in the extracts, physically bound with As(III) via its hydroxyl and carboxyl groups, thereby preventing As(III) accumulation and As(III)-induced ROS generation (Kerdsomboon et al 2021). In plants, the application of Moringa oleifera leaf extract improved the antioxidant enzyme system of wheat plants under salt stress, improving their performance signi cantly (Yasmeen et al 2013).…”

Section: Introductionmentioning

confidence: 98%

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Effects of aqueous Moringa oleifera leaf extract on growth performance and accumulation of cadmium in a Thai jasmine rice—Khao Dawk Mali 105 variety

Auesukaree

Bussarakum

Sirirakphaisarn

et al. 2022

Environ Sci Pollut Res

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The contamination of paddy elds and rice grains by cadmium (Cd) adversely affects human health. Thus, many approaches have been proposed to reduce the accumulation of Cd in rice. Here, we investigate the potential of aqueous Moringa oleifera leaf extract (AMOLE) in decreasing uptake and toxicity of Cd in a popular Thai jasmine rice variety, Khao Dawk Mali 105 (KDML105). Plants were grown in Petri dishes, a hydroponic system, and a pot system under different concentrations of Cd, in the presence and absence of AMOLE. In Petri dishes, Cd reduced the percentage of germination by 79%, but the treatment with 0.5 mg mL -1 AMOLE signi cantly increased the germination percentage. Moreover, AMOLE signi cantly decreased Cd accumulation in rice seedlings by 97%. In the hydroponics system, 0.5 mg mL -1 AMOLE decreased Cd content in shoots by 48%. Although no signi cant physiological changes in response to Cd treatments were observed in the pot system, a large amount of Cd was accumulated in rice roots. The AMOLE treatments signi cantly reduced Cd accumulation in rice shoots and decreased Cd content in milled grain by half compared to those without AMOLE treatment. We conclude that AMOLE reduced Cd toxicity, enhanced seedling growth, and reduced Cd accumulation in rice grains.

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Section: Discussionmentioning

confidence: 99%

Section: Preparation Of Aqueous M Oleifera Leaf Extract (Amole)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Effects of aqueous Moringa oleifera leaf extract on growth performance and accumulation of cadmium in a Thai jasmine rice—Khao Dawk Mali 105 variety

Auesukaree

Bussarakum

Sirirakphaisarn

et al. 2022

Environ Sci Pollut Res

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“…A randomized placebo-controlled study suggested that M. oleifera leaf capsules can be used to control blood sugar level and blood pressure level [97]. Moreover, aqueous extracts of M. oleifera can reduce metal (As (III), Cd, Ni and Pb) toxicity and showed the protective effects in Saccharomyces cerevisiae [98].…”

Section: Prospects For M Oleifera In Drug Developmentmentioning

confidence: 99%

Prospects for Protective Potential of Moringa oleifera against Kidney Diseases

Akter¹,

Rahman²,

Moni³

et al. 2021

Plants

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Kidney diseases are regarded as one of the major public health issues in the world. The objectives of this study were: (i) to investigate the causative factors involved in kidney disease and the therapeutic aspects of Moringa oleifera, as well as (ii) the effectiveness of M. oleifera in the anti-inflammation and antioxidant processes of the kidney while minimizing all potential side effects. In addition, we proposed a hypothesis to improve M. oleifera based drug development. This study was updated by searching the key words M. oleifera on kidney diseases and M. oleifera on oxidative stress, inflammation, and fibrosis in online research databases such as PubMed and Google Scholar. The following validation checking and scrutiny analysis of the recently published articles were used to explore this study. The recent existing research has found that M. oleifera has a plethora of health benefits. Individual medicinal properties of M. oleifera leaf extract, seed powder, stem extract, and the whole extract (ethanol/methanol) can up-increase the activity of antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), while decreasing the activity of inflammatory cytokines such as TNF-α, IL-1β, IL-6, and COX-2. In our study, we have investigated the properties of this plant against kidney diseases based on existing knowledge with an updated review of literature. Considering the effectiveness of M. oleifera, this study would be useful for further research into the pharmacological potential and therapeutic insights of M. oleifera, as well as prospects of Moringa-based effective medicine development for human benefits.

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“…First, as a compound of plant polyphenol, GA is renewable and cost-effective. Second, numerous studies suggest that the structure of GA, together with its derivatives, can remove metal ions by forming a metal complex − and selectively induce detrimental microorganism death by apoptosis without harming healthy cells. − Inspired by this, a new porous β-cyclodextrin-based polymer, PCD-Gs, was prepared for the first time based on the copolymerization of allyl-β-CD and partially allylated gallic acid under different monomer feeding ratios, which is expected to provide new insights into the preparation and application of advanced adsorption materials that could simultaneously and effectively remove OMPs, metal ions, and detrimental microorganisms from contaminated water, thus realizing deep and effective purification of water and simplification of the water treatment process.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional β-Cyclodextrin Polymer for Simultaneous and Effective Removal of Organic Micropollutants, Heavy Metals, and Detrimental Microorganisms from Water

Qin

Liu

Tao

et al. 2022

Ind. Eng. Chem. Res.

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A new porous β-cyclodextrin-based polymer (PCD-Gs) adsorbent was synthesized by the copolymerization of allyl-β-CD and partially allylated gallic acid under different monomer feeding ratios. With a series of single-factor experiments, it was found that the PCD-Gs not only exhibited ultrarapid and efficient absorption capacity for bisphenol A and Cd(II) but also possessed strong bactericidal ability and good resistance to salt and acid. Multivariate analyses showed that there was no competitive adsorption but a positive effect between Cd(II) and bisphenol A on PCD-Gs in the binary system. Besides, the PCD-Gs had outstanding regeneration ability and removal efficiency even at environmentally relevant concentrations. Combined with 1 H NMR analysis, a multimechanism was suggested that the polymer of PCD-Gs possesses multiple action sites and presents great potential for simultaneously and effectively removing organic micropollutants, metal ions, and detrimental microorganisms from contaminated water, which contributes to deep purification of water and simplification of the water treatment process.

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Effects of Moringa oleifera leaf extracts and its bioactive compound gallic acid on reducing toxicities of heavy metals and metalloid in Saccharomyces cerevisiae

Cited by 29 publications

References 51 publications

Effects of aqueous Moringa oleifera leaf extract on growth performance and accumulation of cadmium in a Thai jasmine rice—Khao Dawk Mali 105 variety

Effects of aqueous Moringa oleifera leaf extract on growth performance and accumulation of cadmium in a Thai jasmine rice—Khao Dawk Mali 105 variety

Prospects for Protective Potential of Moringa oleifera against Kidney Diseases

Multifunctional β-Cyclodextrin Polymer for Simultaneous and Effective Removal of Organic Micropollutants, Heavy Metals, and Detrimental Microorganisms from Water

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