Effects of mood stabilizers on oxidative stress-induced cell death signaling pathways in the brains of rats subjected to the ouabain-induced animal model of mania

Valvassori, Samira S.; Resende, Wilson R.; Lopes-Borges, Jéssica; Mariot, Edemilson; Dal‐Pont, Gustavo C.; Vitto, Marcelo F.; Luz, Gabrielle da; Souza, Cláudio Teodoro de; Quevedo, Joao L De

doi:10.1016/j.jpsychires.2015.04.009

Cited by 36 publications

(18 citation statements)

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“…Valvassori and colleagues found that Li modulated antioxidant enzymes and prevented ouabain‐induced mania‐like behavior and oxidative damage in the brains of rats that were subjected to this model of mania. Li also reversed the oxidative damage in the brains of rats subjected to the animal model of mania induced by amphetamine . It was also found that, in an animal model of sepsis, treatments with Li at doses of 25 and 50 mg/kg decreased the levels of 8‐ISO .…”

Section: Discussionmentioning

confidence: 82%

Lithium ameliorates sleep deprivation‐induced mania‐like behavior, hypothalamic‐pituitary‐adrenal (HPA) axis alterations, oxidative stress and elevations of cytokine concentrations in the brain and serum of mice

et al. 2017

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Section: Discussionmentioning

confidence: 82%

Lithium ameliorates sleep deprivation‐induced mania‐like behavior, hypothalamic‐pituitary‐adrenal (HPA) axis alterations, oxidative stress and elevations of cytokine concentrations in the brain and serum of mice

et al. 2017

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“…It has been reported that lithium and the other mood stabilizer valproates protect the cells from the ouabain-induced apoptosis [124]. It is fascinating that the Na + -K + ATPase has been demonstrated to be a link between oxidative damage and neuronal death reported in BD [125]. In a study published in 2012, the lithium-related enhancement of Na + -K + ATPase activity related to a reduction of lipid peroxidation in bipolar patients [126].…”

Section: Methodsmentioning

confidence: 99%

Gsk3 Signalling and Redox Status in Bipolar Disorder: Evidence from Lithium Efficacy

Luca

Calandra

Luca

2016

Oxidative Medicine and Cellular Longevity

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Objective. To discuss the link between glycogen synthase kinase-3 (GSK3) and the main biological alterations demonstrated in bipolar disorder (BD), with special attention to the redox status and the evidence supporting the efficacy of lithium (a GSK3 inhibitor) in the treatment of BD. Methods. A literature research on the discussed topics, using Pubmed and Google Scholar, has been conducted. Moreover, a manual selection of interesting references from the identified articles has been performed. Results. The main biological alterations of BD, pertaining to inflammation, oxidative stress, membrane ion channels, and circadian system, seem to be intertwined. The dysfunction of the GSK3 signalling pathway is involved in all the aforementioned “biological causes” of BD. In a complex scenario, it can be seen as the common denominator linking them all. Lithium inhibition of GSK3 could, at least in part, explain its positive effect on these biological dysfunctions and its superiority in terms of clinical efficacy. Conclusions. Deepening the knowledge on the molecular bases of BD is fundamental to identifying the biochemical pathways that must be targeted in order to provide patients with increasingly effective therapeutic tools against an invalidating disorder such as BD.

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“…Some of these changes were modified by lithium and valproate (Jornada et al, 2011). For example, ouabain decreased levels of Bcl-2 and increased oxidative stress factors such as BAX and pp53 in rat brain (Valvassori et al, 2015). Treatment with both lithium and valproate improved most of these measures, however they were not protective against the increases in BAX in frontal cortex or hippocampus (Valvassori et al, 2015).…”

Section: Pharmacological Models Of Maniamentioning

confidence: 99%

“…For example, ouabain decreased levels of Bcl-2 and increased oxidative stress factors such as BAX and pp53 in rat brain (Valvassori et al, 2015). Treatment with both lithium and valproate improved most of these measures, however they were not protective against the increases in BAX in frontal cortex or hippocampus (Valvassori et al, 2015). In patients with BD, decreased BDNF levels have been described when compared with healthy controls (Machado-Vieira et al, 2007).…”

Section: Pharmacological Models Of Maniamentioning

confidence: 99%

Animal models of bipolar mania: The past, present and future

2016

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Bipolar disorder (BD) is the sixth leading cause of disability in the world according to the World Health Organization and affects nearly 6 million (~2.5% of the population) adults in the United State alone each year. BD is primarily characterized by mood cycling of depressive (e.g., helplessness, reduced energy and activity, and anhedonia) and manic (e.g., increased energy and hyperactivity, reduced need for sleep, impulsivity, reduced anxiety and depression), episodes. The following review describes several animal models of bipolar mania with a focus on more recent findings using genetically modified mice, including several with the potential of investigating the mechanisms underlying ‘mood’ cycling (or behavioral switching in rodents). We discuss whether each of these models satisfy criteria of validity (i.e., face, predictive, and construct), while highlighting their strengths and limitations. Animal models are helping to address critical questions related to pathophysiology of bipolar mania, in an effort to more clearly define necessary targets of first-line medications, lithium and valproic acid, and to discover novel mechanisms with the hope of developing more effective therapeutics. Future studies will leverage new technologies and strategies for integrating animal and human data to reveal important insights into the etiology, pathophysiology, and treatment of BD.

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Effects of mood stabilizers on oxidative stress-induced cell death signaling pathways in the brains of rats subjected to the ouabain-induced animal model of mania

Cited by 36 publications

References 53 publications

Lithium ameliorates sleep deprivation‐induced mania‐like behavior, hypothalamic‐pituitary‐adrenal (HPA) axis alterations, oxidative stress and elevations of cytokine concentrations in the brain and serum of mice

Lithium ameliorates sleep deprivation‐induced mania‐like behavior, hypothalamic‐pituitary‐adrenal (HPA) axis alterations, oxidative stress and elevations of cytokine concentrations in the brain and serum of mice

Gsk3 Signalling and Redox Status in Bipolar Disorder: Evidence from Lithium Efficacy

Animal models of bipolar mania: The past, present and future

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