Effects of mood episodes and comorbid anxiety on neuropsychological impairment in patients with bipolar spectrum disorder

Huang, Chih Chun Jean; Chang, Yun-Hsuan; Wang, Tzu Yun; Lee, Sheng Yu; Chen, Po See; Lane, Hsien Yuan; Yang, Yen Kuang; Lu, Ru Band

doi:10.1002/brb3.1813

Cited by 5 publications

(2 citation statements)

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“…Moreover, the BD group had lower MASC‐CH cognitive mental state scores than the HCs, while the MDD group showed no difference. This may indicate a possible effect of mood severity in the emotional SC, which is similar to neuropsychological functioning, in that both impair state‐like markers depending on the mood episodes of BD patients (Huang et al., 2020 ) .…”

Section: Discussionmentioning

confidence: 99%

Discrepancy of social cognition between bipolar disorders and major depressive disorders

Chang,

Yu,

Huang

et al. 2023

Brain and Behavior

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BackgroundThe research landscape examining social cognition (SC) impairment in patients with major depressive disorders (MDD) and bipolar disorders (BD) is notably scarce. Presently, assessments predominantly rely on static stimuli and self‐reported measures, which may not capture the dynamic dimensions of social cognition.ObjectivesThis study aimed to validate the Chinese version of Movie Assessment of Social Cognition (MASC‐CH) and to investigate whether MDD and BD exhibit distinct patterns of SC impairments, shedding light on potential differences between these two mood disorders.MethodsThe study encompassed 197 participants, aged 18–65, distributed as follows: 21 BD, 20 MDD, and 156 healthy controls (HC). We focused on examining “cognitive” and “emotional” SC scores and “undermentalizing” and “overmentalizing” error patterns, with nonsocial inference as a control. Additional assessments included the Reading Mind in the Eyes Test (RMET) and the Mayer–Salovey–Caruso Emotional Intelligence Test (MSCEIT). We also explored the association between depression severity (measured by the Hamilton Depressive Rating Scale, HDRS) and distinct SC dimensions between MDD and BD.ResultsThe MASC‐CH exhibited strong validity and reliability for SC assessment. In group comparisons, BD participants scored significantly lower on MASC‐CH, while the MDD group scores were not significantly different from HC. Specifically, BD individuals had notably lower cognitive SC scores and made more undermentalizing and absence of mentalizing errors than MDD and HC. Additionally, a negative correlation between HDRS score and overmentalizing was observed in BD, not in the MDD.ConclusionsThe findings indicate that depression severity scores in BD were inversely related to MASC‐CH scores. In contrast, this relationship was not observed in the MDD group. These results underscore the importance of SC impairments as distinguishing characteristics of both BD and MDD. It provides valuable insights into the distinct social‐cognitive profiles of both mood disorders.

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Section: Discussionmentioning

confidence: 99%

Discrepancy of social cognition between bipolar disorders and major depressive disorders

Chang,

Yu,

Huang

et al. 2023

Brain and Behavior

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“…However, the correlation with mood symptomatology is not clear. Although neuropsychological impairment has been suggested as a feature of BD, some domains of neuropsychological performance were found to be related to mood episodes ( 51 ). Thus, in the current study, we investigated whether impairment in the different sub-facets of the MSCEIT is related to BD patients' mood episodes.…”

Section: Introductionmentioning

confidence: 99%

Impairment in Emotional Intelligence May Be Mood-Dependent in Bipolar I and Bipolar II Disorders

et al. 2021

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Background: An emotional intelligence (EI) deficit has been noticed in euthymic bipolar spectrum disorder (BD) patients. However, whether this deficit is affected by mood or subtype is unclear.Objectives:The aim of this study was to investigate whether an EI deficit is mood-dependent, and which mood symptoms have more impact on EI in BD.Methods: Two hundred and thirty participants aged between 18 and 65 years old were recruited [130 BD patients (51 bipolar I disorder (BDI) and 79 bipolar II disorder (BDII): 39.2% males; 91 healthy controls (HCs): 48.4% males)]. The Mayer–Salovey–Caruso Emotional Intelligence Test (MSCEIT), which contains experiential and strategic EI ratings, was used to assess social cognition. The Hamilton Depression Rating Scale (HDRS) and the Young's Mania Rating Scale (YMRS) were used for evaluating the severity [HAMD and YMRS scores ≦7 were euthymic (BDeut) and HAMD YMRS sores ≧8 were episodic (BDepi)]. Analyses of covariance (ANCOVA) were performed, with adjustment for background information between the BD patients and HCs.Results: The results showed that, compared to the HCs, the BDeut patients showed no difference in any MSCEIT measures, while the BDepi patients showed lower scores in all MSCEIT measures, except for perceiving emotions. In addition, a main effect of mood state instead of BD subtype was found for the managing emotions branch (p < 0.0007). Regression analyses showed that the duration of illness and HDRS scores were correlated with the scores in the strategic area of the MSCEIT, while age and YMRS scores were more relevant to the scores in the experiential area of the MSCEIT.Conclusion: The results confirm that an EI deficit is mood-dependent in BD patients. In addition, a depressive mood is more related to the strategic EI area, while a manic mood is correlated with the experiential EI area. Understanding the different domains of EI deficits in BD patients may be helpful for developing interventions for BD.

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Affective Disorders

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2021

Essential Neuropsychology: A Concise Handbook for Adult Practitioners

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Effects of mood episodes and comorbid anxiety on neuropsychological impairment in patients with bipolar spectrum disorder

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 5 publications

References 53 publications

Discrepancy of social cognition between bipolar disorders and major depressive disorders

Discrepancy of social cognition between bipolar disorders and major depressive disorders

Impairment in Emotional Intelligence May Be Mood-Dependent in Bipolar I and Bipolar II Disorders

Affective Disorders

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